ABSTRACT
The effect of polymyxin M on the microflora artifically introduced into the digestive tract of gnotobiotic chickens was studied. It was found that polymyxin M caused dysbacteriosis in the digestive tract. Reduction of the impaired biocenosis after discontinuation of polymyxin use was rapid and practically complete.
Subject(s)
Germ-Free Life/drug effects , Intestines/microbiology , Polymyxins/pharmacology , Actinomycetaceae/drug effects , Animals , Candida albicans/drug effects , Chickens , Ecology , Enterococcus faecalis/drug effects , Escherichia coli/drug effects , Feces/microbiology , Lactobacillus/drug effects , Salmonella/drug effects , Time FactorsSubject(s)
Candida albicans/pathogenicity , Chickens , Escherichia coli/pathogenicity , Salmonella/pathogenicity , Animals , Candidiasis/microbiology , Candidiasis/veterinary , Escherichia coli Infections/microbiology , Escherichia coli Infections/veterinary , Germ-Free Life , Poultry Diseases/microbiology , Salmonella Infections, Animal/microbiologyABSTRACT
Levomycetin effect on the microflora introduced into the intestine of abiotic chickens was studied. Levomycetin in a dose of 4 mg perosone chicken for 5 days provided a decrease in the number of Bifidobacteria, Lactobacteria, Escherichia and Enterococci by 100 to 10000 times and an increase in the number of Candida or disbacteriosis in the intestine. The highest effect was observed with respect to multiplication of Lactobacteria. This impaired the ecological quantitative ratio between the microorganisms. Re-establishment of the microbial biocenosis after discontinuation of levomycetin use was not complete. Repeated disbacteriosis in the gastrointestinal tract of the test-chickens was registered on the 16th day.
