[Interrelations of organ systems]. / Uber die Interrelationen der Organsysteme.

The main features of interrelations between different organ systems are described and their possible role in therapeutic aims discussed. In the question on the connection of immunoallergic phenomena and vegetative nervous system the authors' standpoint on their mutual interrelation is stressed. The most important characters of the immunoallergic organ system are studied and its correlations with the female hormonal factors interpreted; further therapeutic trials in this aspect seem to be justified. The problem of mutual stimulation between certain organ systems' functions is likewise dealt with.

[Classification of immunodeficiency]. / Klassifizierung von Immundefizienz.

The immunodeficiency, at present an important complex of research, can be classified in 4 main groups. Primary forms can be separated from secondary ones, a third group of interactional type from a fourth one of compensatory character. We suggest a new classification based on a common point of view, which avoids terms as "common variable immunodeficiency" and allows corrections by the results of further research.

Oddi's sphincter spasm in hypocalcaemia of dogs.

1. Decreases of serum calcium concentration in dogs lead to increased basal tone of Oddi's sphincter in the employed experimental model. 2. This effect is independent of the agent used for decreasing the serum calcium level. 3. Spasmolysis was observed immediately after the injection of CaCl2. CaCl2 alone, however, had no effect in "normocalcaemic" animals. 4. Local decrease of calcium level plays no significant role in the sphincter spasm. It is suggested that the spasm is elicited by increased smooth muscle excitability as a consequence of the hypocalcaemic state prevailing in the body.

Regulatory hyperparathyroidism: the role of C-cell hyperplasia.

Four cases with clinical and biochemical evidence of hyperparathyroidism are reported. The syndrome was due to DHT-intoxication of iatrogenic origin in the first case to histologically confirmed C-cell hyperplasia of the thyroid in the three others. The collective term "regulatory hyperparathyroidism" is porposed for the syndromes which, in distinction to secondary parathyroidisms, have a pathogenesis other than a negative calcium balance. Management of the syndrome is discussed with particular emphasis on the removal of the TCT-producing hyperplasia or adenoma, and the restoration of the electrolyte balance.

[Infectious and neoplastic complications in rheumatoid arthritis]. / Uber infektiöse und neoplastische Komplikationen der Rheumatoiden Arthritis

Three cases are reported of rheumatic arthritis protracted over several decades, with reduced immunobiological resistance, who developed infectious arthritis, a syndrome with urticaria and angio-edematous signs and increased monoclonal IgM synthesis, and Hodgkin's disease. The discussion covers the manifold pathogenesis, the common and simultaneous effect of constitutional, local factors of the development of the disease, related to the generally reduced resistance of the organism, and the therapeutical moments (corticosteroids, immunosuppressives); further the establishment of therapeutical measures in the interest of the prevention of the complications mentioned.