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1.
Disasters ; 48(1): e12590, 2024 Jan.
Article in English | MEDLINE | ID: mdl-37192426

ABSTRACT

Natural hazards can turn into disasters when not managed well. An important part of disaster risk reduction is to understand how well communities are prepared for natural hazards and how well they can cope with and recover from shocks in the long term. This research assesses self-reported community resilience and asks what makes a community resilient, using Australia as a case study. It reports on an Australian-wide online survey which included questions related to the Conjoint Community Resiliency Assessment Measurement, a subjective indicator, as well as questions about risk perception, well-being, and self-efficacy. Community resilience was found to be moderately high but scores for community leadership and preparedness were low. Perceived community resilience was positively correlated with age and those with high scores for self-efficacy and well-being. There was, as expected, an inverse relationship between reliance on external support during natural hazards and self-efficacy. The results complement previous studies which used different measures of community resilience.


Subject(s)
Disaster Planning , Disasters , Resilience, Psychological , Humans , Disaster Planning/methods , Australia , Surveys and Questionnaires
2.
Animals (Basel) ; 12(5)2022 Feb 23.
Article in English | MEDLINE | ID: mdl-35268123

ABSTRACT

The good intentions of zoos to introduce enrichment practices that stimulate animals mentally and physically are not always achievable. Changes to the policies and procedures in organisations are difficult to fulfil for a range of reasons frequently investigated in change management literature. The implementation of these changes can be the source of ineffective attempts to generate positive interventions in organisations. In this study, we investigate whether interventions to improve animal management in zoos through enrichment are subject to implementation impediments. Qualitative data gathered from interviews with 23 keepers working with big cats across 12 zoos globally provided valuable insights into the barriers and enablers to the implementation of enrichment. Keepers participated voluntarily and worked in accredited zoos across Australia, New Zealand, Europe, south-east Asia, South Africa, and the United States of America. Thematic analysis of the data revealed five key themes that described some of the challenges zoos and keepers experience when implementing enrichment for big cats, in their words: "let's just be cautious", "purely surviving", "struggle to understand the goal", "can't always provide what you should", and "judge the effectiveness". These themes provide additional insights into potential areas for improvement, including greater attention to the benefits of enrichment for animal mental health and increased transparency around enrichment objectives in zoos.

3.
Behav Med ; 48(3): 147-161, 2022.
Article in English | MEDLINE | ID: mdl-33226915

ABSTRACT

Many psychological inclinations, such as maladaptive beliefs, can diminish the capacity of individuals to manage their weight effectively and sustainably. Yet, interventions that purportedly address these psychological inclinations and improve weight management are not always beneficial. To be effective, these interventions should offer participants several choices, should be devoid of features that have not been validated in isolation, and should arrange the various activities in an efficient and effective sequence. Few if any programs fulfill these criteria. The aim of this paper was to construct an intervention that assimilates all the validated features of interventions that overcome the psychological impediments to weight loss. To achieve this goal, we blended a technique called intervention component analysis with thematic analysis. Specifically, we extracted refereed journal articles about weight loss from PsycInfo, distilled the practical recommendations from these articles, excluded recommendations that had not been validated in isolation of other features, integrated overlapping recommendations, and applied several principles to arrange these recommendations into the most effective sequence. This procedure generated an intervention that could comprise up to 43 features and activities, including self-affirmation to foster openness to change, anecdotes about dramatic improvements, ambitious rather than modest targets, an emphasis on strategies rather than targets, rewards for attempts, implementation intentions with partners, self-hypnosis, cognitive reframing, and distancing. If these features are unsuccessful, practices that demand more resources-such as group disclosure, virtual environments, motivational interviewing, and customized programs-were also recommended.


Subject(s)
Psychosocial Intervention , Weight Loss , Humans , Intention , Motivation
4.
J Pharm Pract Res ; 51(6): 464-471, 2021 Dec.
Article in English | MEDLINE | ID: mdl-35464638

ABSTRACT

Background: Consumer stockpiling from pharmacies has been reported by media outlets throughout the course of COVID-19. Aim: This study evaluated pharmacists' perceptions of consumer stockpiling from pharmacies, the impact of stockpiling, aggressive or hostile behaviour from customers and preparedness for COVID-19 and future pandemics. Method: A self-administered survey was disseminated between September and November of 2020. The survey comprised four major sections: demographic information, experiences of consumer stockpiling, impact of consumer stockpiling and preparedness for COVID-19 and future pandemics. Survey results were analysed in Microsoft Excel using descriptive statistics. Results: Of the 56 responses analysed, most pharmacists observed consumer stockpiling of over-the-counter products (98.2%), schedule 2 and schedule 3 medications (92.8%) and prescription only medications (94.6%). The most commonly stockpiled items included face masks, hand-sanitisers and wipes, alcohol wipes and antiseptic solutions, thermometers, paracetamol and salbutamol inhalers. Patients also requested the dispensing of several months' supply of regular prescription medications. Customer aggression was observed by 53.6% of pharmacists, with 63% of pharmacists agreeing that hostile behaviour impeded their practice. Only 36.7% of pharmacists felt adequately prepared to cope with the challenges of COVID-19. Conclusion: Consumer stockpiling from pharmacies was observed throughout COVID-19. Stockpiling as well as aggressive and hostile behaviour from customers affected pharmacists, their staff, business and other pharmacy customers. Additional studies are needed to investigate the severity of these issues and to inform policy changes to help mitigate consumer stockpiling and prepare the pharmacy profession for future pandemics.

5.
Front Psychol ; 11: 568723, 2020.
Article in English | MEDLINE | ID: mdl-33132976

ABSTRACT

Organized physical activity (OPA) is an important contributor to physical, social, and emotional health and well-being; however, young people with disabilities are participating at lower rates than their peers without disabilities. This study aimed to (1) compare facilitators and barriers to OPA for young people with disabilities who currently do and do not participate in OPA and (2) to assess whether groups differed in the type of internal and external assets they reported. Parents of 218 young people (41% with a primary diagnosis of autism spectrum disorder) with a diverse representation of disabilities completed an online survey. Young people were categorized as either participants in OPA (n = 131) or non-participants (n = 87) by parent report. Non-participation was significantly predicted by the barrier "there are no activities my child enjoys" and by a lack of children's motivation and happiness during OPA. Significant internal assets differentiating participants from non-participants were the ability to understand simple instructions, love of sport, and meeting physical activity guidelines. Significant external assets were parent and sibling participation in OPA, school type, and household income. The findings from this study have important implications for the design of public health interventions that aim to promote OPA in young people with disabilities, highlighting the need to make activities enjoyable, promote participation of siblings and parents, and support low-income families to participate.

6.
Health Promot Int ; 35(1): e32-e42, 2020 Feb 01.
Article in English | MEDLINE | ID: mdl-30590556

ABSTRACT

Research has not definitively ascertained the circumstances that motivate people to live a healthier lifestyle. To redress this shortfall, we report two overlapping studies that examined whether people are more inclined to value health benefits that seem enduring and fundamental rather than transient or superficial-even after controlling effort and cost. In these studies, 242 participants indicated the degree to which they implement 17 health behaviours-as well as the extent to which they perceive the benefits of these behaviours as enduring and fundamental. Furthermore, participants completed a measure that gauges future clarity. Finally, they chose which of two drugs-drugs that differ only on the longevity of effects-they prefer. Participants were more inclined to implement health behaviours that seemed to generate enduring and fundamental benefits. This effect was more pronounced in people who perceive their future as vivid and certain. Furthermore, participants tended to choose the drug that was touted as generating more enduring benefits, even after controlling cost and effort. As these results imply, to encourage healthy behaviour, health practitioners should help people clarify their future goals and then advocate behaviours that generate lasting benefits.


Subject(s)
Forecasting , Health Behavior , Motivation , Adult , Aged , Attention/drug effects , Drug-Related Side Effects and Adverse Reactions , Female , Humans , Life Style , Male , Middle Aged , Pharmaceutical Preparations/administration & dosage , Surveys and Questionnaires
7.
Int J Aging Hum Dev ; 86(1): 82-108, 2018 01.
Article in English | MEDLINE | ID: mdl-28105868

ABSTRACT

Socioemotional selectivity theory assumes that older individuals tend to perceive their identity or life as limited in time and, therefore, prioritize meaningful relationships. Yet, other research shows that people who perceive their identity as limited in time tend to behave impulsively-contrary to the behavior of many older individuals. To redress this paradox, this article reports a systematic review, comprising 86 papers, that examined the consequences of whether individuals perceive their identity as limited or enduring. To reconcile conflicts in the literature, we propose that, before an impending transition, some individuals perceive their life now as dissociated from their future goals and, therefore, will tend to behave impulsively. Other individuals however, especially if older, tend to pursue a quest or motivation that transcends this transition, fostering delayed gratification, and responsible behavior.


Subject(s)
Aging/psychology , Social Behavior , Humans
8.
J Health Psychol ; 23(13): 1689-1698, 2018 11.
Article in English | MEDLINE | ID: mdl-27663287

ABSTRACT

Many impulsive behaviors, unpleasant emotions, and misguided cognitions increase the incidence of type 2 diabetes and other conditions. This study tests the premise that such risk factors are inversely related to future clarity-the extent to which the future seems vivid and certain. Specifically, 211 participants completed the measures of future clarity and various determinants of health. Future clarity was positively associated with the inclination of participants to consume healthy food, abstain from cigarettes, participate in physical activity, and experience positive emotions. Future research should examine whether interventions designed to help individuals clarify and pursue their aspirations could stem lifestyle diseases.


Subject(s)
Aspirations, Psychological , Forecasting , Health Behavior , Healthy Lifestyle , Internal-External Control , Motivation , Adolescent , Adult , Cognition , Diabetes Mellitus, Type 2/etiology , Diabetes Mellitus, Type 2/prevention & control , Emotions , Exercise/psychology , Female , Health Status , Humans , Male , Middle Aged , Optimism/psychology , Risk Factors , Uncertainty , Young Adult
9.
Stress Health ; 33(5): 608-616, 2017 Dec.
Article in English | MEDLINE | ID: mdl-28198128

ABSTRACT

Some research shows that people who often contemplate their future tend to be healthier. Yet the burgeoning literature on mindfulness demonstrates that people who are more attuned to their immediate experiences also enjoy many benefits. To reconcile these principles, many scholars recommend that people should distribute their attention, somewhat evenly, across the past, present, and future-but have not clarified how people should achieve this goal. We test the possibility that people who perceive their future as vivid and certain, called future clarity, might be able to both orient their attention to the future as well as experience mindfulness. Specifically, future clarity could diminish the inclination of people to reach decisions prematurely and dismiss information that contradicts these decisions, called need for closure-tendencies that diminish consideration of future consequences and mindfulness, respectively. In this cross-sectional study, 194 participants completed measures of mindfulness, consideration of future consequences, need for closure, and future clarity. Consistent with hypotheses, future clarity was positively associated with both mindfulness and consideration of future consequences. Need for closure partly mediated these relationships. Accordingly, interventions that empower people to shape and to clarify their future might generate the benefits of both mindfulness and a future orientation.


Subject(s)
Attention/physiology , Attitude , Decision Making/physiology , Mindfulness , Adolescent , Adult , Aged , Cross-Sectional Studies , Female , Forecasting , Humans , Male , Middle Aged , Young Adult
10.
Environ Res ; 152: 272-279, 2017 Jan.
Article in English | MEDLINE | ID: mdl-27816864

ABSTRACT

Heat stress causes reductions in well-being and health. As average annual temperatures increase, heat stress is expected to affect more people. While most research on heat stress has explored how exposure to heat affects functioning of the human organism, stress from heat can be manifest long before clinical symptoms are evident, with profound effects on behavior. Here we add to the little research conducted on these subclinical effects of environmental heat using results from an Australian-wide cross-sectional study of nearly 2000 respondents on their self-reported level of heat stress. Slightly less than half (47%) of the respondents perceived themselves as at least sometimes, often or very often stressed by heat during the previous 12 months. Health status and smoking behavior had the expected impact on self-reported perceived heat stress. There were also regional differences with people living in South Australia, Victoria and New South Wales most likely to have reported to have felt heat stressed. People generally worried about climate change, who had been influenced by recent heat waves and who thought there was a relationship between climate change and health were also more likely to have been heat stressed. Surprisingly average maximum temperatures did not significantly explain heat stress but stress was greater among people who perceived the day of the survey as hotter than usual. Currently heat stress indices are largely based on monitoring the environment and physical limitations to people coping with heat. Our results suggest that psychological perceptions of heat need to be considered when predicting how people will be affected by heat under climate change and when developing heat relief and climate change adaptation plans, at work, at home or in public spaces. We further conclude that the perception of temperature and heat stress complements measures that assess heat exposure and heat strain.


Subject(s)
Employment , Heat Stress Disorders/epidemiology , Adolescent , Adult , Aged , Australia/epidemiology , Employment/statistics & numerical data , Female , Geography , Heat Stress Disorders/etiology , Humans , Male , Middle Aged , Perception , Self Report , Young Adult
11.
Br J Educ Psychol ; 87(1): 32-42, 2017 Mar.
Article in English | MEDLINE | ID: mdl-27753081

ABSTRACT

BACKGROUND AND AIMS: Lecturers often present entertaining videos, or organize a variety of amusing demonstrations, to foster student engagement or to encourage critical analysis. Magic tricks, in particular, have been shown to activate neural circuits that underpin motivation or problem-solving and, therefore, could be beneficial during lectures. Nevertheless, we hypothesize that, unless the method that underpins these tricks is revealed, students may ruminate over possible explanations, distracting attention from the lecture material. SAMPLE AND METHODS: To test these arguments, in this study, 224 participants watched a video of a magic performance, watched a video of a circus act, or watched no video at all. In half the participants who watched the magic performance, the secret that underpinned the trick was disclosed. Next, participants watched a psychology tutorial, before answering questions that assessed engagement, need for cognition, and comprehension of the material. RESULTS: If the secret was withheld, magic tricks diminished subsequent need for cognition but did not affect comprehension. Furthermore, magic tricks tended to diminish engagement with the subsequent tutorial. These effects, however, were small. CONCLUSION: Future research is warranted to ascertain whether information that is embedded within a magic trick, rather than presented after the trick, is more likely to be remembered or understood later. This research could clarify when performance can enhance or disrupt student engagement.


Subject(s)
Attention/physiology , Comprehension/physiology , Magic/psychology , Students/psychology , Adult , Female , Humans , Male , Young Adult
12.
Explore (NY) ; 11(1): 40-50, 2015.
Article in English | MEDLINE | ID: mdl-25457443

ABSTRACT

RATIONALE: According to some scholars, if individuals experience over three times as many positive emotions as negative emotions, they are more likely to thrive. We contend, however, that perhaps positive and negative emotions that overlap in time are likely to enhance wellbeing. Specifically, if positive and negative emotions are experienced simultaneously rather than separately-called ambivalent emotions-the fundamental needs of individuals are fulfilled more frequently. EVIDENCE: Considerable evidence supports this perspective. First, many emotions that enhance wellbeing, although classified as positive, also coincide with negative feelings. Second, ambivalent emotions, rather than positive or negative emotions separately, facilitate creativity and resilience. Third, ambivalent emotions activate distinct cognitive systems that enable individuals to form attainable goals, refine their skills, and enhance their relationships.


Subject(s)
Affect , Emotions , Mental Health , Personal Satisfaction , Uncertainty , Cognition , Creativity , Humans , Resilience, Psychological
13.
J Psychosom Obstet Gynaecol ; 34(3): 122-8, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23952170

ABSTRACT

The failure rate of in vitro fertilization (IVF) is around 75% per cycle. These unsuccessful attempts can provoke acute clinical depression and other problems. Although practitioners often recommend cognitive reappraisal, rather than avoidance, to cope with these difficulties, previous research has not established the psychosocial determinants of adaptive coping strategies. Arguably, resilience could encourage cognitive reappraisal, because resilient individuals feel confident they can overcome their emotions, whereas marital quality could prevent avoidance, because individuals feel secure enough to reflect upon their distress. Consequently, resilience and marital quality could facilitate recovery over time. To explore these possibilities, 184 women, all of whom had unsuccessfully completed IVF treatment, completed a questionnaire that gauged their levels of self-reported depression since their last IVF attempt as well as resilience and marital quality. Immediately after the unsuccessful attempt, resilience was inversely, whereas marital quality was positively, related to depression. However, within this cross-sectional sample after greater time had elapsed, marital quality became increasingly beneficial and was negatively associated with depression. These findings imply that resilience can curb the initial distress; in contrast, marital quality may enable individuals to reflect upon their trauma, initially amplifying distress but eventually facilitating recovery. Future research would benefit from longitudinal studies, illustrating whether resilience and marital quality at one time predict changes in distress at subsequent times.


Subject(s)
Adaptation, Psychological , Depression/diagnosis , Fertilization in Vitro/psychology , Infertility/psychology , Resilience, Psychological , Spouses/psychology , Adult , Depression/psychology , Diagnostic Self Evaluation , Emotions , Female , Humans , Infertility/therapy , Marriage/psychology , Middle Aged , Psychiatric Status Rating Scales , Surveys and Questionnaires , Treatment Failure
14.
Accid Anal Prev ; 48: 416-22, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22664707

ABSTRACT

Rail accidents can be understood in terms of the systemic and individual contributions to their causation. The current study was undertaken to determine whether errors and violations are more often associated with different local and organisational factors that contribute to rail accidents. The Contributing Factors Framework (CFF), a tool developed for the collection and codification of data regarding rail accidents and incidents, was applied to a sample of investigation reports. In addition, a more detailed categorisation of errors was undertaken. Ninety-six investigation reports into Australian accidents and incidents occurring between 1999 and 2008 were analysed. Each report was coded independently by two experienced coders. Task demand factors were significantly more often associated with skill-based errors, knowledge and training deficiencies significantly associated with mistakes, and violations significantly linked to social environmental factors.


Subject(s)
Accidents , Railroads , Social Environment , Staff Development , Australia , Causality , Humans , Observer Variation , Retrospective Studies , Safety Management , Task Performance and Analysis , Time Factors , Workload
15.
Neurology ; 77(7): 618-22, 2011 Aug 16.
Article in English | MEDLINE | ID: mdl-21775729

ABSTRACT

OBJECTIVE: This study determined whether CGG repeat length moderates the relationship between age and performance on selective measures of executive function in premutation carriers (PM) who are asymptomatic for a recently described late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). METHODS: Forty PM men aged 18-69 years with a family history of fragile X syndrome underwent neuropsychological tests of inhibition and working memory. We examined only men who are asymptomatic for FXTAS. Multiple regression analyses were conducted to examine the moderating role of CGG repeat length on the relation between age and performance on inhibition and working memory tasks. RESULTS: With increasing age and only in men with an FMR1 expansion in the upper premutation range (>100 CGG repeats) was there an association between age and poorer task performance on selective executive function measures involving inhibition (p < 0.05) and executive working memory (p < 0.01). Men in the lower premutation range (<100 CGG repeats) were relatively risk-free from any cognitive aging effects associated with CGG repeat expansions. CONCLUSIONS: We conclude that neural networks in the prefrontal cortex may be highly susceptible to age-related neurotoxic effects in the upper size range of the FMR1 premutation. Future longitudinal studies will be needed to determine whether specific executive markers may serve to distinguish those at greatest risk for severe cognitive decline or dementia associated with FXTAS.


Subject(s)
Ataxia/genetics , Executive Function/physiology , Fragile X Mental Retardation Protein/genetics , Fragile X Syndrome/genetics , Tremor/genetics , Adult , Age Factors , Aged , Ataxia/physiopathology , Fragile X Syndrome/physiopathology , Genetic Association Studies , Genetic Predisposition to Disease , Humans , Inhibition, Psychological , Male , Memory, Short-Term/physiology , Middle Aged , Neuropsychological Tests , Prefrontal Cortex/physiopathology , Tremor/physiopathology , Trinucleotide Repeat Expansion
16.
J Neurol Sci ; 301(1-2): 51-8, 2011 Feb 15.
Article in English | MEDLINE | ID: mdl-21095618

ABSTRACT

Previous studies have reported that people with the neurodevelopmental disorder Williams syndrome exhibit difficulties with visuomotor control. In the current study, we examined the extent to which visuomotor deficits were associated with movement planning or feedback-based on-line control. We used a variant of the Fitts' reciprocal aiming task on a computerized touchscreen in adults with WS, IQ-matched individuals with Down syndrome (DS), and typically developing controls. By manipulating task difficulty both as a function of target size and amplitude, we were able to vary the requirements for accuracy to examine processes associated with dorsal visual stream and cerebellar functioning. Although a greater increase in movement time as a function of task difficulty was observed in the two clinical groups with WS and DS, greater magnitude in the late kinematic components of movement-specifically, time after peak velocity-was revealed in the WS group during increased demands for accuracy. In contrast, the DS group showed a greater speed-accuracy trade-off with significantly reduced and more variable endpoint accuracy, which may be associated with cerebellar deficits. In addition, the WS group spent more time stationary in the target when task-related features reflected a higher level of difficulty, suggestive of specific deficits in movement planning. Our results indicate that the visuomotor coordination deficits in WS may reflect known impairments of the dorsal stream, but may also indicate a role for the cerebellum in dynamic feed-forward motor control.


Subject(s)
Ataxia/physiopathology , Psychomotor Performance/physiology , Vision Disorders/physiopathology , Williams Syndrome/physiopathology , Adult , Ataxia/etiology , Biomechanical Phenomena , Cerebellum/physiopathology , Down Syndrome/physiopathology , Feedback, Sensory , Female , Humans , Male , Spinal Cord/physiopathology , User-Computer Interface , Williams Syndrome/complications , Young Adult
17.
J Neurol Sci ; 291(1-2): 57-63, 2010 Apr 15.
Article in English | MEDLINE | ID: mdl-20138309

ABSTRACT

Williams syndrome (WS), a rare genetically based neurodevelopmental disorder, is characterized by gait abnormalities that resemble basal ganglia-parkinsonian deficits in the internal regulation of stride length. In the current study, we explored whether visual or attentional cues would improve gait function in adults with WS, when compared to adults with Down syndrome (DS) and neurologically normal controls. The spatiotemporal characteristics of gait were measured using the GAITRite walkway while participants walked with visual cues set at 20% greater than preferred stride length (externally cued), or with an attentional strategy of maintaining the stride length without the assistance of visual cues (internally cued). Although the WS and DS groups were able to achieve the criterion and normalize stride length in both conditions, the WS group significantly reduced their gait speed and cadence in the externally cued condition when compared to controls. In the internally cued condition, the WS group also showed reduced speed and increased intra-individual variability in speed and stride time. These findings suggest that the primary deficit is not one of difficulty regulating stride length in WS, but rather indicates more widespread dysfunction within visuomotor regions.


Subject(s)
Attention , Cues , Walking , Williams Syndrome , Adult , Biomechanical Phenomena , Down Syndrome/physiopathology , Female , Gait/physiology , Humans , Male , Photic Stimulation , Psychomotor Performance/physiology , Task Performance and Analysis , Time Factors , Walking/physiology , Williams Syndrome/physiopathology , Young Adult
18.
Autism ; 12(3): 249-60, 2008 May.
Article in English | MEDLINE | ID: mdl-18445734

ABSTRACT

The aim of this study was to investigate whether the superior search abilities observed in autism/Asperger's disorder may in part be a consequence of a more pronounced inhibition of return (IOR). Contrary to our prediction, IOR in individuals with autism was comparable to the matched comparison group. However, the autism group committed more false alarm responses than the matched comparison group; this may reflect a possible inhibitory deficit, or suggest that individuals with autism rely more on probabilities to determine their behavioural responses. There was a borderline-significant trend (p=0.052) to indicate that IOR may be more pronounced in individuals with Asperger's disorder. In contrast to the autism group, the Asperger's disorder group had a pattern of false alarm responses similar to that of the comparison group. The findings further inform Minshew's complex information processing theory which seeks to establish which areas of neuropsychological functioning are preserved and deficit in autism.


Subject(s)
Asperger Syndrome/diagnosis , Attention , Autistic Disorder/diagnosis , Inhibition, Psychological , Neuropsychological Tests , Pattern Recognition, Visual , Psychomotor Performance , Reaction Time , Adolescent , Asperger Syndrome/psychology , Autistic Disorder/psychology , Child , Diagnosis, Differential , Female , Humans , Male , Probability Learning
19.
Brain ; 130(Pt 11): 2837-44, 2007 Nov.
Article in English | MEDLINE | ID: mdl-17928318

ABSTRACT

Beta-amyloid (Abeta) deposition is pathognomic for Alzheimer's disease (AD), but may occur in normal elderly people without apparent cognitive effect. Episodic memory impairment is an early and prominent sign of AD, but its relationship with Abeta burden in non-demented persons and in AD patients is unclear. We examined this relationship using 11C-PIB-PET as a quantitative marker of Abeta burden in vivo in healthy ageing (HA), mild cognitive impairment (MCI) and AD. Thirty-one AD, 33 MCI and 32 HA participants completed neuropsychological assessment and a 11C-PIB-PET brain scan. Multiple linear regression analyses were conducted relating episodic memory performance and other cognitive functions to Abeta burden. Ninety-seven percent of AD, 61% of MCI and 22% of HA cases had increased cortical PIB binding, indicating the presence of Abeta plaques. There was a strong relationship between impaired episodic memory performance and PIB binding, both in MCI and HA. This relationship was weaker in AD and less robust for non-memory cognitive domains. Abeta deposition in the asymptomatic elderly is associated with episodic memory impairment. This finding, together with the strong relationship between PIB binding and the severity of memory impairment in MCI, suggests that individuals with increased cortical PIB binding are on the path to Alzheimer's disease. The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted.


Subject(s)
Alzheimer Disease/diagnosis , Amyloid beta-Peptides/analysis , Cerebellar Cortex/pathology , Cognition Disorders/diagnosis , Memory , Aged , Alzheimer Disease/metabolism , Alzheimer Disease/psychology , Aniline Compounds , Apolipoproteins E/genetics , Benzothiazoles , Biomarkers/analysis , Carbon Radioisotopes , Case-Control Studies , Cerebellar Cortex/metabolism , Chi-Square Distribution , Cognition Disorders/metabolism , Cognition Disorders/psychology , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Mutation , Neuropsychological Tests , Positron-Emission Tomography , Thiazoles
20.
Autism ; 10(1): 70-85, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16522711

ABSTRACT

The repetitive, stereotyped and obsessive behaviours, which are core diagnostic features of autism, are thought to be underpinned by executive dysfunction. This study examined executive impairment in individuals with autism and Asperger's disorder using a verbal equivalent of an established pseudo-random number generating task. Different patterns of disinhibition emerged in the autism (n = 12) and Asperger's disorder (n = 12) groups. Consistent with previous research, the autism group repeated single numbers (e.g. 2, 2, 2) more frequently than the control group. In contrast to past research suggesting intact executive abilities, this study found that the Asperger's disorder group generated more repetitive number patterns (e.g. 45, 45) than the controls. Executive functioning in children with Asperger's disorder may be particularly vulnerable to a lack of visual cueing and concrete rules. Qualitative differences in executive dysfunction between these groups may implicate differential disruption within the fronto-striatal circuitry.


Subject(s)
Asperger Syndrome/epidemiology , Autistic Disorder/epidemiology , Cognition Disorders/diagnosis , Cognition Disorders/epidemiology , Mathematics , Child , Female , Humans , Male , Neuropsychological Tests , Severity of Illness Index
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