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1.
Eye (Lond) ; 31(1): 113-118, 2017 Jan.
Article in English | MEDLINE | ID: mdl-27636230

ABSTRACT

PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied.ResultsThe Caucasian cohort was slightly older (mean=76.1 years) than the African-American cohort (mean=72.6 years, P=0.03), and there was no difference in sex distribution between the two cohorts. Headache, neck pain, and anemia were more frequent, while jaw claudication was less frequent in African-Americans (P<0.01, <0.001, 0.02, and 0.03 respectively). Acute vision loss was the most common presentation of giant cell arteritis in both groups, though it was less common in African-Americans (78 vs 98% of Caucasians, P<0.001). Eye pain was more common in African-Americans (28 vs 8% of Caucasians, P<0.01).ConclusionsThe presenting features of ophthalmic giant cell arteritis in African-Americans and Caucasians are not markedly different, although a few significant differences exist, including higher rates of headache, neck pain, anemia, and eye pain, and lower rates of jaw claudication and acute vision loss in African-Americans. Persons presenting with suspicious signs and symptoms should undergo evaluation for giant cell arteritis regardless of race.


Subject(s)
Black or African American/statistics & numerical data , Eye Pain/epidemiology , Giant Cell Arteritis/complications , Vision Disorders/epidemiology , Aged , Aged, 80 and over , Eye Pain/etiology , Female , Giant Cell Arteritis/epidemiology , Giant Cell Arteritis/physiopathology , Humans , Male , Middle Aged , Retrospective Studies , Sex Distribution , Temporal Arteries/pathology , United States/epidemiology , Vision Disorders/etiology , Visual Acuity/physiology , White People/statistics & numerical data
2.
Br J Ophthalmol ; 93(2): 231-4, 2009 Feb.
Article in English | MEDLINE | ID: mdl-18567649

ABSTRACT

BACKGROUND/AIMS: To report a case series of Idiopathic Elevated Episcleral Venous Pressure (IEEVP). METHODS: Retrospective chart review of all cases of IEEVP seen over a 5-year period by three physicians. RESULTS: Six cases (five men and one woman) are added to the known 19 documented cases in the English literature, only three of which were reported in the last 10 years. By history, the onset of conjunctival injection of all patients was in early adulthood or late teens. None had an identifiable lesion by modern imaging techniques. All cases had bilateral but asymmetric involvement. Four of the six required glaucoma surgery by the 5th to 7th decade of life. The three eyes that had glaucoma filtration surgery had good outcomes. Choroidal effusions occurred in the postoperative period of one eye which was not hypotonous. CONCLUSION: IEEVP is a rare cause of glaucoma which is diagnosed by the clinical criteria of dilated episcleral vessels without an identifiable cause. If glaucoma filtration surgery is required, there are generally good results. However, clinicians must be cautious of choroidal effusions occurring at non-hypotonous intraocular pressures.


Subject(s)
Glaucoma, Open-Angle/etiology , Sclera/blood supply , Varicose Veins/complications , Adult , Aged , Female , Glaucoma, Open-Angle/physiopathology , Glaucoma, Open-Angle/surgery , Humans , Intraocular Pressure , Male , Middle Aged , Retrospective Studies , Trabeculectomy , Varicose Veins/diagnosis , Varicose Veins/physiopathology , Venous Pressure
3.
Ophthalmol Clin North Am ; 14(1): 205-15, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11370567

ABSTRACT

Patients who present with nystagmus may have visual loss, a benign peripheral vestibular abnormality, or an important central nervous system disorder. The clinical history, features of nystagmus on examination, and accompanying symptoms and findings often help to localize the lesion. These features also determine the appropriate evaluation and treatment of the underlying disorder. Additionally, if there is oscillopsia or blurred vision, treatment of the nystagmus itself may be warranted. Possible treatments include medication, optical manipulations, and surgery.


Subject(s)
Nystagmus, Pathologic , Humans , Nystagmus, Pathologic/classification , Nystagmus, Pathologic/complications , Nystagmus, Pathologic/diagnosis , Nystagmus, Pathologic/therapy
4.
J Neuroophthalmol ; 21(4): 264-5, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11756856

ABSTRACT

A patient developed pendular seesaw nystagmus after receiving radiation and intrathecal methotrexate treatment for central nervous system lymphoma. Nystagmus developed without evidence of a brainstem lesion on magnetic resonance imaging. This case expands the causes of seesaw nystagmus and lends further support to the notion that midbrain lesions are not a prerequisite for its development.


Subject(s)
Antimetabolites, Antineoplastic/adverse effects , Brain/drug effects , Brain/radiation effects , Methotrexate/adverse effects , Nystagmus, Pathologic/etiology , Radiation Injuries/etiology , Antimetabolites, Antineoplastic/administration & dosage , Brain Neoplasms/drug therapy , Brain Neoplasms/radiotherapy , Humans , Injections, Spinal , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/radiotherapy , Magnetic Resonance Imaging , Methotrexate/administration & dosage , Middle Aged , Optic Chiasm/drug effects , Optic Chiasm/radiation effects , Optic Nerve/drug effects , Optic Nerve/radiation effects , Visual Fields
5.
Br J Ophthalmol ; 84(10): 1185-90, 2000 Oct.
Article in English | MEDLINE | ID: mdl-11004108

ABSTRACT

AIM: This study was designed to test the ability of a portable computer driven, head mounted visual field testing system to perform automated perimetry on patients at their bedside and to compare these results with the "gold standard" for bedside examinations, confrontation visual fields. METHODS: The Kasha visual field system is a portable automated perimeter which utilises a virtual reality headset. 37 neurosurgery patients were examined at their bedside with a central 24 degree suprathreshold testing strategy after confrontation visual field testing. The patterns of visual field defects were categorised and compared with the results of confrontation testing. RESULTS: A total of 42 field examinations were completed on 37 patients, and the average testing time for both eyes was 4.8 minutes with the perimetry system. Each of the 11 fields (100%) classified with defects on confrontation testing was similarly categorised on head mounted perimetry. 26 out of 31 (84%) visual fields were normal on both confrontation and perimetry testing, while five out of the 31 fields (16%) which were full on confrontation had visual field defects identified by head mounted perimetry. CONCLUSION: The head mounted, automated perimetry system proved easily portable and convenient for examining neurosurgical patients at their bedside in the perioperative period. The device demonstrated equal sensitivity to confrontation visual field testing methods in detecting field defects and offers the advantage of standardised, quantifiable testing with graphic results for follow up examinations.


Subject(s)
Point-of-Care Systems , Visual Field Tests/instrumentation , Visual Fields , Adult , Aged , Craniotomy , Head , Humans , Male , Middle Aged , Perioperative Care/instrumentation , Prospective Studies , Reproducibility of Results , Time Factors
7.
Article in English | MEDLINE | ID: mdl-10779264

ABSTRACT

PURPOSE: To study the function of the parvocellular (P) and the magnocellular (M) visual systems with steady-state visual evoked potentials (VEPs) in anisometropic amblyopes. METHODS: A matrix of isolated checks was superimposed on a steady background with different check sizes and temporal frequencies to form specific stimuli to preferentially activate the P or the M visual system. The amplitude of the VEP fundamental frequency was analyzed at the electrode Oz of 5 anisometropic amblyopes and 22 normal subjects. The normal subjects were tested at two visual acuity (VA) levels, 20/20 and 20/40, modified by lenses, to match with the VA levels of the fellow eyes and the amblyopic eyes of the amblyopes, respectively. RESULTS: No significant amplitude difference was found between the dominant eyes and nondominant eyes of the normal subjects for either P or M stimuli at both 20/20 and 20/40 VA levels (P>.05). No significant amplitude difference was found between the fellow eyes of the amblyopes and the dominant eyes of normals for either P or M stimuli at 20/20 VA level (P>.05). A significant amplitude difference was found between the amblyopic eyes and the nondominant eyes of the normals for P stimuli (P<.05) but not for M stimuli (P>.05) at 20/40 VA level. CONCLUSIONS: The amplitude of the VEP fundamental frequency was selectively reduced for P stimuli in anisometropic amblyopic eyes. This clinical electrophysiologic finding confirms that only the function of the P visual system is abnormal in anisometropic amblyopic eyes.


Subject(s)
Amblyopia/physiopathology , Anisometropia/physiopathology , Evoked Potentials, Visual/physiology , Visual Cortex/physiopathology , Visual Pathways/physiopathology , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Visual Acuity
8.
Neurology ; 53(4): 877-9, 1999 Sep 11.
Article in English | MEDLINE | ID: mdl-10489061

ABSTRACT

The authors describe five patients with trochlear nerve palsy and MS to characterize this rare association. In two patients, trochlear nerve palsy was the initial clinical manifestation of MS. In the other three patients, this sign occurred after previous neurologic events. MRI did not identify a lesion of the fourth nerve nucleus or fascicle. Ophthalmoplegia resolved within 2 months in four of the five patients. A reason this association is rare is that the fascicular course of the trochlear nerve is exposed to little myelin.


Subject(s)
Multiple Sclerosis/complications , Paralysis/pathology , Trochlear Nerve/pathology , Adult , Child , Female , Humans , Male , Middle Aged , Paralysis/complications
9.
Curr Opin Ophthalmol ; 10(6): 376-81, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10662241

ABSTRACT

The devastating, blinding effects of diabetic retinopathy have been well publicized. Although individually less common, many neuro-ophthalmologic complications are also associated with diabetes. The vascular effects of diabetes contribute to nonarteritic ischemic optic neuropathy, vasculopathic cranial neuropathies, and strokes affecting both afferent visual function and ocular motility. The neuropathic effects of diabetes primarily affect pupillary function, and the immunosuppressive effects of diabetes predispose to certain infections, such as mucormycosis. Diabetes is also associated with numerous congenital syndromes. This paper reviews the literature published in the past year on the neuro-ophthalmologic effects of diabetes.


Subject(s)
Blindness/etiology , Diabetes Complications , Eye Abnormalities/etiology , Macular Edema/etiology , Ocular Motility Disorders/etiology , Optic Neuropathy, Ischemic/etiology , Blindness/diagnosis , Blindness/prevention & control , Delivery of Health Care/methods , Diabetes Mellitus/therapy , Eye Abnormalities/diagnosis , Eye Abnormalities/prevention & control , Humans , Macular Edema/diagnosis , Macular Edema/prevention & control , Ocular Motility Disorders/diagnosis , Ocular Motility Disorders/prevention & control , Optic Neuropathy, Ischemic/diagnosis , Optic Neuropathy, Ischemic/prevention & control , Visual Acuity
10.
J Neuroophthalmol ; 18(4): 292-3, 1998 Dec.
Article in English | MEDLINE | ID: mdl-9858016

ABSTRACT

A patient developed periodic alternating nystagmus, periodic alternating gaze deviation, and periodic alternating head rotation as a manifestation of a seizure. This occurred as he awakened after hypoxic ischemic encephalopathy. Seizures should be added to the list of differential diagnoses of periodic alternating nystagmus.


Subject(s)
Epilepsy/diagnosis , Nystagmus, Pathologic/diagnosis , Occipital Lobe , Periodicity , Aged , Diagnosis, Differential , Epilepsy/complications , Humans , Male , Nystagmus, Pathologic/etiology
11.
Semin Ultrasound CT MR ; 19(3): 216-24, 1998 Jun.
Article in English | MEDLINE | ID: mdl-9686685

ABSTRACT

The practice of neuro-ophthalmology includes evaluating patients for visual signs and symptoms for neurological causes. Responsible lesions are often small and in places not well imaged on routinely ordered brain imaging studies. To achieve a proper diagnosis, the clinician must have a close working relationship with the radiologist to choose the appropriate imaging study and to correctly focus the study based on clinical findings.


Subject(s)
Diagnostic Imaging/methods , Eye Diseases/diagnosis , Adult , Aged , Diagnosis, Differential , Eye Diseases/diagnostic imaging , Eye Diseases/etiology , Female , Humans , Interprofessional Relations , Male , Middle Aged , Neuroradiography , Ophthalmology , Vision Disorders/diagnosis , Vision Disorders/diagnostic imaging , Vision Disorders/etiology
12.
Surv Ophthalmol ; 42(5): 453-7, 1998.
Article in English | MEDLINE | ID: mdl-9548574

ABSTRACT

A 70-year-old man underwent coronary artery bypass graft complicated postoperatively by visual loss. The diagnosis was nonarteritic anterior ischemic optic neuropathy. Possible predisposing factors in this patient were hypotension, anemia, a "disk at risk," and internal carotid artery stenosis. In the postoperative setting, the erythrocyte sedimentation rate may be elevated, as it was in this case and does not by itself suggest a diagnosis of giant cell arteritis.


Subject(s)
Blindness/etiology , Coronary Artery Bypass/adverse effects , Optic Neuropathy, Ischemic/etiology , Postoperative Complications , Aged , Blindness/diagnosis , Blood Sedimentation , Coronary Disease/surgery , Diagnosis, Differential , Follow-Up Studies , Humans , Male , Optic Disk/pathology , Optic Neuropathy, Ischemic/diagnosis , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Visual Acuity , Visual Fields
13.
Chin Med Sci J ; 11(2): 69-72, 1996 Jun.
Article in English | MEDLINE | ID: mdl-9387411

ABSTRACT

PURPOSE: To investigate the peak latency of the orbital presaccadic spike potential (SP) with horizontal eye movement in normals. METHODS: Orbital SP was recorded in 28 normal subjects from 8 electrodes around the eyes with Pz as the reference while performing 5 degrees, 10 degrees, 20 degrees, 30 degrees and 40 degrees horizontal saccades to visual targets. SP peak latency was measured from SP onset to SP peak on averaged data aligned on SP peak. RESULTS: Significant main effects on SP peak latency are found for saccade size (P < 0.01), saccade direction (P < 0.01) and electrode site (P < 0.05). No significant main effect on SP peak latency is found for eye (P > 0.05). SP peak latency increases with increasing saccade size from 5 degrees to 40 degrees. SP peak latency is longer with saccades back to center than away from center, and with abducting saccades than with adducting saccades. SP peak latency differs at the electrode sites with an order from shorter to longer as follows: inner canthus (IC); inferior orbit (IO); outer canthus (OC); superior orbit (SO). CONCLUSIONS: The effects on the peak latency of orbital SP can be explained by the saccade dynamic property, volume conduction as well as physiologic and anatomic factors of the eyes and orbits. The peak latency of orbital SP can be used to reflect the temporal characteristics of ocular motor units controlling saccadic eye movement.


Subject(s)
Saccades/physiology , Adolescent , Adult , Child , Electrooculography , Evoked Potentials , Female , Humans , Male , Middle Aged , Reaction Time/physiology
14.
Surv Ophthalmol ; 40(5): 395-9, 1996.
Article in English | MEDLINE | ID: mdl-8779086

ABSTRACT

Neuroimaging with nuclear medicine techniques permits assessment of brain function by measurement of metabolism or blood flow. Such studies complement the anatomic information derived from computed tomography (CT) or magnetic resonance imaging (MRI). We describe two patients with occipital lesions who were initially diagnosed with functional visual loss. Neither CT scan nor MRI adequately demonstrated the source of visual dysfunction; however, single proton emission tomography (SPECT) scanning in a patient with carbon monoxide poisoning and positron emission tomography (PET) scanning in a patient with post-hypoxic delayed encephalopathy were helpful in confirming the organic substrate of their visual impairment. Functional imaging techniques such as SPECT and PET should be considered in patients with suspected cortical visual loss and normal CT or MR scans.


Subject(s)
Carbon Monoxide Poisoning/diagnostic imaging , Hypoxia, Brain/diagnostic imaging , Occipital Lobe/diagnostic imaging , Tomography, Emission-Computed, Single-Photon/methods , Tomography, Emission-Computed/methods , Vision Disorders/diagnostic imaging , Adult , Carbon Monoxide Poisoning/etiology , Carbon Monoxide Poisoning/physiopathology , Cerebrovascular Circulation , Female , Humans , Hypoxia, Brain/etiology , Hypoxia, Brain/physiopathology , Magnetic Resonance Imaging , Male , Occipital Lobe/physiopathology , Tomography, X-Ray Computed , Vision Disorders/etiology , Vision Disorders/physiopathology , Visual Cortex/physiopathology , Visual Fields
15.
Electroencephalogr Clin Neurophysiol ; 95(6): 475-7, 1995 Dec.
Article in English | MEDLINE | ID: mdl-8536576

ABSTRACT

Effects of two time-point selection averaging techniques on orbital SP amplitude were studied on 10 normal subjects performing horizontal saccades. One technique involved averaging from the SP peak, another technique involved averaging from the saccadic onset. The time-point selection methods only affected the magnitude of SP amplitude but did not interact with experimental conditions. Repeated measures analysis of variance showed that SP amplitudes were higher in data aligned on SP peak than those aligned on saccadic onset (P < 0.01). No significant second order (saccade by degree) or third order (saccade by direction) interactions involving averaging method were found (P > 0.05).


Subject(s)
Evoked Potentials/physiology , Saccades/physiology , Adolescent , Adult , Child , Electrooculography , Female , Humans , Male , Middle Aged , Time Factors
16.
Surv Ophthalmol ; 39(5): 409-16, 1995.
Article in English | MEDLINE | ID: mdl-7604365

ABSTRACT

A patient with elevated intracranial pressure from aqueductal stenosis presented with unilateral disk edema, enlarged blind spot and a vague visual disturbance. The importance of considering elevated intracranial pressure in some cases without bilateral papilledema is emphasized.


Subject(s)
Cerebral Aqueduct/pathology , Optic Disk/pathology , Papilledema/etiology , Pseudotumor Cerebri/diagnosis , Adult , Constriction, Pathologic/complications , Constriction, Pathologic/diagnosis , Diagnosis, Differential , Female , Fundus Oculi , Humans , Hydrocephalus/complications , Hydrocephalus/diagnosis , Intracranial Pressure , Magnetic Resonance Imaging , Papilledema/diagnosis , Pseudotumor Cerebri/complications , Visual Fields
17.
Am J Ophthalmol ; 113(6): 702-5, 1992 Jun 15.
Article in English | MEDLINE | ID: mdl-1598963

ABSTRACT

Oculomotor nerve paresis, ocular hypotony, anterior segment ischemia, and the ocular ischemic syndrome are uncommon manifestations of giant cell arteritis. Four patients with these findings had giant cell arteritis documented by temporal artery biopsy. Cerebral angiography or ultrasonography, or both, performed in three patients, excluded hemodynamically significant stenosis of the internal carotid artery as the cause of ocular ischemia and cerebral aneurysms as the cause of oculomotor nerve paresis. Corticosteroid treatment, administered to three patients, resulted in resolution of the oculomotor deficits and the clinical signs of ocular ischemia, although the visual acuity in one patient improved from 20/400 to 20/60. Giant cell arteritis should be considered in the differential diagnosis of the ocular ischemic syndrome.


Subject(s)
Eye/blood supply , Giant Cell Arteritis/complications , Ischemia/complications , Uveitis/complications , Aged , Carotid Stenosis/complications , Carotid Stenosis/drug therapy , Female , Giant Cell Arteritis/drug therapy , Humans , Ischemia/drug therapy , Male , Methylprednisolone/therapeutic use , Syndrome , Uveitis/drug therapy , Visual Acuity
18.
J Clin Neuroophthalmol ; 12(2): 94-7, 1992 Jun.
Article in English | MEDLINE | ID: mdl-1629377

ABSTRACT

Six patients with thyroid ophthalmopathy presented with what appeared to be a unilateral superior oblique paresis by the three-step test, which was eventually followed by more typical findings of thyroid disease. This early motility defect in thyroid ophthalmopathy may be caused by a restrictive process due to involvement of the inferior rectus muscle. Clues to the proper diagnosis included an increase in vertical deviation in upgaze, elevation of intraocular tension in upgaze, and the lack of excyclodeviation. These features should be assessed in patients with isolated superior oblique paresis.


Subject(s)
Graves Disease/diagnosis , Paralysis/diagnosis , Trochlear Nerve , Adult , Aged , Cranial Nerve Diseases/diagnosis , Cranial Nerve Diseases/etiology , Diplopia/diagnosis , Eye Movements , Female , Graves Disease/complications , Humans , Male , Middle Aged , Ophthalmoplegia/diagnosis , Visual Acuity
19.
Arch Neurol ; 48(5): 490-7, 1991 May.
Article in English | MEDLINE | ID: mdl-2021362

ABSTRACT

The group of six patients in this study experienced delayed visual loss following head trauma. Visual loss occurred from 1 day to 13 years after the initial injury. All patients suffered indirect trauma to the internal carotid artery resulting in formation of either an aneurysm or pseudoaneurysm or a carotid-cavernous fistula. Review of the radiologic and clinical findings was performed in six patients. The diagnosis was established by computed tomography, magnetic resonance imaging, and angiography. All patients had follow-up clinical evaluation and imaging studies. Treatment by neurosurgical or interventional neuroradiologic procedures resulted in significant visual improvement in five patients. Different pathophysiologic mechanisms could be correlated with the delayed visual loss produced by the two types of lesions. The pathologic changes associated with the aneurysms/pseudoaneurysms included direct compression of optic nerves and/or chiasm and intracranial hematoma. A carotid-cavernous fistula caused delayed visual loss by either hematoma at the orbital apex or compression of the chiasm and/or optic nerves by saccular dilatation of the cavernous sinus. The delayed onset of decreased vision following head trauma should alert the physician to the possibility of a traumatic aneurysm/pseudoaneurysm or a carotid-cavernous fistula. Different neuro-ophthalmologic symptoms can usually be correlated with the pathologic changes demonstrated by neuroimaging procedures.


Subject(s)
Carotid Artery Diseases/complications , Craniocerebral Trauma/complications , Intracranial Aneurysm/complications , Vision Disorders/etiology , Adolescent , Adult , Carotid Artery Diseases/diagnosis , Carotid Artery Diseases/etiology , Carotid Artery, Internal , Cerebral Angiography , Female , Follow-Up Studies , Humans , Intracranial Aneurysm/diagnosis , Intracranial Aneurysm/etiology , Magnetic Resonance Imaging , Male , Time Factors , Tomography, X-Ray Computed , Vision Disorders/physiopathology , Visual Fields
20.
J Neurosurg ; 74(3): 426-32, 1991 Mar.
Article in English | MEDLINE | ID: mdl-1993908

ABSTRACT

Optic neuropathy induced by radiation is an infrequent cause of delayed visual loss that may at times be difficult to differentiate from compression of the visual pathways by recurrent neoplasm. The authors describe six patients with this disorder who experienced loss of vision 6 to 36 months after neurological surgery and radiation therapy. Of the six patients in the series, two had a pituitary adenoma and one each had a metastatic melanoma, multiple myeloma, craniopharyngioma, and lymphoepithelioma. Visual acuity in the affected eyes ranged from 20/25 to no light perception. Magnetic resonance (MR) imaging showed sellar and parasellar recurrence of both pituitary adenomas, but the intrinsic lesions of the optic nerves and optic chiasm induced by radiation were enhanced after gadolinium-diethylenetriaminepenta-acetic acid (DTPA) administration and were clearly distinguishable from the suprasellar compression of tumor. Repeated MR imaging showed spontaneous resolution of gadolinium-DTPA enhancement of the optic nerve in a patient who was initially suspected of harboring recurrence of a metastatic malignant melanoma as the cause of visual loss. The authors found the presumptive diagnosis of radiation-induced optic neuropathy facilitated by MR imaging with gadolinium-DTPA. This neuro-imaging procedure may help avert exploratory surgery in some patients with recurrent neoplasm in whom the etiology of visual loss is uncertain.


Subject(s)
Optic Nerve Diseases/diagnosis , Radiation Injuries/diagnosis , Aged , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Optic Nerve Diseases/etiology , Optic Nerve Diseases/surgery
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