Subject(s)
Anemia, Aplastic/microbiology , Antifungal Agents/therapeutic use , Mouth Diseases/microbiology , Mycoses/complications , Mycoses/drug therapy , Natamycin/therapeutic use , Administration, Oral , Adolescent , Antifungal Agents/administration & dosage , Child , Child, Preschool , Humans , Infant , Leukemia, Myeloid, Acute/microbiology , Mouth Diseases/drug therapy , Natamycin/administration & dosage , Preleukemia/microbiologyABSTRACT
2.5% solution in the form of oral drops (Gist-brocades) has been used in the treatment of Candida albicans infections of the mucous membranes in children with chronic blood diseases. Out of 34 children 28 recovered completely which is 82.3% of all cases. The highest effectiveness of the preparation was found in the group of children with acute infections. In all cases of chronic candidiasis the improvement of the clinical condition was obtained. Only few children have not shown the growth of Candida albicans in the control investigations.
Subject(s)
Candidiasis, Oral/drug therapy , Hematologic Diseases/complications , Natamycin/administration & dosage , Opportunistic Infections/drug therapy , Adjuvants, Immunologic , Administration, Oral , Adolescent , Antifungal Agents , Candidiasis, Oral/etiology , Child , Child, Preschool , Clinical Trials as Topic , Hematologic Diseases/drug therapy , Hematologic Diseases/immunology , Humans , Immune Tolerance/drug effects , Immune Tolerance/immunology , Infant , Opportunistic Infections/etiologyABSTRACT
A total of 34 children with oral candidiasis were treated with 2.5% natamycin in the form of orally administered drops; 6-20 drops applied to oral lesions four times daily for up to 8 weeks. A total cure was achieved in 28 (82.3%) cases. No side-effects were observed. This preparation was an effective treatment for Candida albicans infections in children with blood diseases, and was well tolerated.
