Subject(s)
Colon/transplantation , Immunosuppression Therapy/methods , Immunosuppressive Agents/therapeutic use , Intestine, Small/transplantation , Transplantation, Homologous/immunology , Adolescent , Azathioprine/therapeutic use , Drug Therapy, Combination , Graft Rejection/drug therapy , Humans , Intestine, Small/surgery , Male , Methylprednisolone/therapeutic use , Reoperation , Tacrolimus/therapeutic use , Tissue and Organ Harvesting/methods , Transplantation, Homologous/methods , Treatment OutcomeSubject(s)
Graft Rejection/immunology , Immunophenotyping/methods , Liver Transplantation/immunology , Lymphocytes/immunology , Antigens, CD/blood , B-Lymphocyte Subsets/immunology , Follow-Up Studies , Graft Rejection/epidemiology , HLA-DR Antigens/blood , Humans , Predictive Value of Tests , Prognosis , T-Lymphocyte Subsets/immunology , Time FactorsABSTRACT
The first enzyme in the dolichol pathway of protein N-glycosylation, dolichol-P-dependent N-acetylglucosamine-1-phosphate transferase, GPT, has been implicated in the development of a wide variety of eukaryotes. GPT is encoded by ALG7, an early growth-response gene, whose expression has been shown to affect the extent of N-glycosylation and secretion of proteins. To initiate the molecular characterization of ALG7 involvement in mammalian growth and differentiation, we have used the postnatally developing hamster submandibular gland (SMG) as an experimental paradigm. In this study we report that the ALG7 gene was differentially expressed during postnatal development and in terminally differentiated adult tissues. Throughout development, GPT activity paralleled ALG7 mRNA levels, suggesting that the amount of functional enzyme was determined by modulation of transcript abundance.
Subject(s)
Aging/metabolism , Gene Expression Regulation, Enzymologic , Transferases (Other Substituted Phosphate Groups)/biosynthesis , Animals , Animals, Newborn , Cell Differentiation , Cricetinae , Female , Intracellular Membranes/enzymology , Microsomes/enzymology , Organ Specificity , Pregnancy , RNA, Messenger/analysis , RNA, Messenger/biosynthesis , Submandibular Gland/enzymology , Submandibular Gland/growth & development , Transcription, Genetic , Transferases (Other Substituted Phosphate Groups)/metabolismABSTRACT
The authors analysed 167 repeated operations after heart valve prosthetics, which were conducted from 1978 to 1988. The operations were undertaken for the second time mainly in a severe contingent of patients. The reasons for the repeated operations were specific complications according to which 2 groups of patients were set apart: with dysfunction of the prosthesis of noninfectious origin and with prosthetic endocarditis. Study showed that repeated operative intervention undertaken in time reduces considerably its risk and produces a stable positive effect in most cases.
Subject(s)
Aortic Valve/surgery , Heart Valve Prosthesis , Mitral Valve/surgery , Tricuspid Valve/surgery , Adolescent , Adult , Child , Endocarditis/etiology , Female , Heart Valve Prosthesis/adverse effects , Humans , Male , Middle Aged , ReoperationSubject(s)
Echocardiography , Heart Valve Prosthesis/adverse effects , Postoperative Complications/diagnosis , Adolescent , Adult , Aortic Valve , Child , Female , Heart Valve Prosthesis/mortality , Humans , Male , Middle Aged , Mitral Valve , Postoperative Complications/etiology , Postoperative Complications/mortality , Prosthesis Design , Prosthesis Failure , ReoperationSubject(s)
Heart Valve Prosthesis , Mitral Valve , Rheumatic Heart Disease/surgery , Adult , Heart Valve Diseases/surgery , Humans , Male , ReoperationABSTRACT
Foram estudados 90 pacientes adultos de ambos sexos com estado fisico (ASA), submetidos a anestesia com agentes venosos quetamina, tiopental, e alfatesin. Os pacientes foram divididos em dois grupos A e G. O grupo a recebeu como medicacao pre-anestesica acido acetil salicilico em solucao de glicose via oral 2 horas antes do inicio da anestesia, e o grupo G recebeu apenas glicose. Foram medidos os tempos de sono e inducao, e colhido sangue para medida de hematocrito, hemoglobina, proteinas totais, e fracoes. O peso corporal era registrado. Os autores nao encontraram qualquer influencia das pequenas variacoes de massa corporal, elementos sanguineos e uso de moderadas doses de aspirina, sobre o tempo de inducao e duracao do sono quando sao usados estes agentes venosos
