Fabrication and characterization of a Bi2O3-modified chitosan@ZIF-8 nanocomposite for enhanced drug loading-releasing efficacy.

In this study, a simple novel hybrid mesoporous nanomaterial derived from a metal-organic framework (ZIF-8) and chitosan, which were coated on green bismuth oxide, has been successfully synthesized, characterized, and applied to investigate its dapsone loading-releasing capability in the aqueous media. This suggested nanocomposite showed promise for drug loading from water b using hydrogen bonds, pi-pi, and electrostatic interactions. Structural and morphological analyses were performed on the proposed green synthesized nanocomposite through scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, Brunauer-Emmett-Teller analysis, and thermogravimetric analysis. Various influencing parameters, including pH, nanocomposite dose, and contact time, were investigated to optimize the dapsone loading process. Utilizing the non-linear optimization methodology, the results show that dapsone-loading efficiency was >85 % for 50 mg.L-1 of dapsone drug. The optimum parameters for achieving maximal loading of dapsone drug were pH = 6.8, hybrid mesosphere dose = 2.6 mg.mL-1, and time = 53 min. Based on the release investigations, the dapsone-loaded nanocomposite was put into phosphate buffer saline, at pH = 7.4 and T = 37 °C, with a maximum efficiency of 93.9 after 24 h.

Green Synthesis and Characterization of Bismuth Oxide Nanoparticle Using Mentha Pulegium Extract.

In recent years, green synthesis of nanoparticles has attracted a great attention because of medicine and biological applications. In this work, bismuth oxide nanoparticles (Bi2O3 NP) was prepared via green synthesis using mentha pulegium aqueous extract after 24 h at 90°C. The product was characterized by ultraviolet-visible (UV-VIS) spectrophotometer, Fourier transform infrared (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscope (TEM), energy-dispersive X-ray spectroscopy (EDS), and diffuse reflection spectroscopy (DRS). The antibacterial activities of the samples were determined against Salmonella and Escherichia coli (E.Coli) as Gram-negative bacterial and Staphylococcus aureus (S.aureus) as Gram-positive bacterial. The objectives of this study were the green synthesis of bismuth oxide nanoparticles using aqueous extract with a good potential for UV blocking and antibacterial activity. Based on the obtained results, Bi2O3 NPs can have a good candidate for different applications.

Preparation and evaluation of ZnO nanoparticles by thermal decomposition of MOF-5.

In recent years, the use of zinc oxide nanoparticles (ZnO NPs) has attracted considerable attention due to its unique properties. In this study, ZnO nanoparticles were synthesized by a simple and repeatable method with thermal decomposition of a zinc-based metal organic framework (Zn-MOF). MOF-5 was prepared by solution (at room temperature) and solvothermal (at 90 °C) methods in dimethylformamide (DMF) as a solvent via the self-assembly of zinc acetate and dehydrate benzene-1,4-dicarboxylate (BDC) as metal ion center and organic bridging ligand respectively without and with tri-ethylamine (TEA) as capping agent. The result products were characterized by Fourier transform infrared (FTIR) for investigation functional groups, X-ray diffraction (XRD) for determination of crystalline structure, scanning electron microscope (SEM) for evaluation of size and morphology, energy-dispersive X-ray spectroscopy (EDS) for determination of chemical composition, and diffuse reflection spectroscopy (DRS) for investigation of Ultraviolet (UV) protective properties. The antibacterial activities of ZnO NPs were studied against Escherichia coli (E. coli).

Application of a Nanoporous Metal Organic Framework Based on Iron Carboxylate as Drug Delivery System.

In the present study, a nanoporous metal organic framework (MOF) based on iron metal and amino terephthalate ligand MIL-101-NH2-Fe has been used as a carrier for loading and in-vitro release of 5-flurouracil (5-FU) anticancer drug. The 5-FU drug loaded MOF was 13 wt % by using thermogravimetric analysis (TGA). The 5-FU release was monitored under physiological condition at 37 °C, pH 7.4 in simulated body fluid (SBF) by using spectrophotometry. The drug demonstrated a slow release profile where 98% of the drug was released in 4 days. Loading of drug was characterized by Fournier transform infrared (FTI-IR) and thermogravimetric analysis (TGA). The crystalline structure was monitored by using X-ray powder diffraction (XRD) and after loading of drug in the MOF, the pattern of samples was remained the same. The morphology and size of samples were showed by using scanning electron microscopy (SEM) and based on the MOF has a length of 500 nm and an average diameter of 200 nm. These structural characterizations were performed to verify the 5-FU drug loading in MIL-101-NH2-Fe. The MOF stability was studied by measuring the iron concentration in the SBF solution with atomic absorption spectroscopy (AAS). The MTT assay method was assessed the ability of this drug delivery system on overcoming MCF-7 breast cancer cells in comparison with the free drug and the carrier alone. Based on the results, this drug loaded nanoparticle could achieve more cell death as compared to the free 5-FU drug.