Revisión de casos de intoxicaciones agudas accidentales por calcipotriol y tacalcitol en perros en el CNITV (Francia) (1999-2003) / A review of accidental acute poisonings by calcipotriol and tacalcitol in dogs at the CNITV (France) (1999-2003)

Recientemente la ingestión accidental de cremas tópicas antipsoriáticas se ha descrito en perros. En el presente trabajo se revisan los casos más documentados que se han registrado en el Centro Nacional de Informaciones Toxicológicas Veterinarias de Lyon (Francia) en los últimos cuatro años [1999-2003], de intoxicación en perros por tacalcitol y calcipotriol. De los 20 casos seleccionados 9 son por calcipotriol y 11 por tacalcitol. Se han observado efectos a nivel gastrointestinal, neuromotor, hepático y renal. Se observan a su vez alteraciones en distintos parámetros bioquímicos. Apreciamos un menor tiempo medio de aparición de síntomas en los intoxicados por tacalcitol, así como un mayor porcentaje de mortalidad. De la discusión de los datos disponibles podemos concluir que la intoxicación por tacalcitol es mucho más severa en perros que la intoxicación por calcipotriol (AU)

Recently, accidental ingestion of topical antipsoriatic ointments in dogs has been described. This work describes the most documented cases of accidental poisoning, by tacalcitol and calcipotriol, in dogs registered by the National Centre of Veterinary Toxicological Information in Lyon (France) during the last four years [1999-2003]. 20 accidental poisoning cases have been selected due to the involvement of the aforementioned substances, 9 cases by calcipotriol and the other 11 cases by tacalcitol. These substances caused effects on gastrointestinal and neuromotor systems, liver and kidneys. In addition, some modifications were observed with biochemical parameters. Mortality percentages were higher in the cases by tacalcitol, and the clinical signs after ingestion appeared earlier than in the cases involving calcipotriol. According to the results we can concluded that tacalcitol accidental poisonings in dogs are more severe than those by calcipotriol (AU)

Intentional poisoning of animals in southeastern Spain: a review of the veterinary toxicology service from Murcia, Spain.

Data of toxicological analyses carried out over a 10-y period for suspected cases of wild and domestic animal poisonings are summarized. Of the 123 cases suspected as deliberate, 102 were be analyzed and 50 of them were positive to intentional poisoning, a total of 107 dead animals. Pesticides, especially insecticides (72%) and rodenticides (26%), were frequently involved. Aldicarb (n=15), anticoagulant rodenticides (n=8) and strychnine (n=4) were the most common toxins in baits prepared for intentional poisonings; carbofuran, methomyl, endosulfan and paraquat were also used. A coordinated Veterinary Toxicology Services network of collaboration should be set up in Spain to improve the quality of the services provided.

Animales envenenados: La experiencia de diez años del Servicio de Toxicologia de la Universidad de Murcia / Animals intentionally poisoned: the 10-year experience of the toxicology service of the University of Murcia

Se revisan los datos seleccionados de 10 años de análisis químico toxicológico realizados en el Servicio de Toxicología de Murcia (España), por la sospecha de envenenamientos en animales domésticos y silvestres. De los 123 casos seleccionados y confirmados como intencionados, se pudieron analizar 102 de los cuales 50 fueron positivos a envenenamiento, con un balance de 107 animales muertos. Plaguicidas, sobre todo insecticidas (72 por ciento) y rodenticidas (26 por ciento), fueron los más frecuentemente involucrados. Aldicarb (n=15), rodenticidas anticoagulantes (n=8) y estricnina (n=4) fueron los tóxicos más utilizados en la preparación de cebos para envenenamientos; también se encontró carbofurano, metomilo, endosulfán o paraquat. Siete de los nueve Laboratorios de Toxicología de las Facultades de Veterinaria de España coinciden en señalar que la creación de una red coordinada de colaboración entre dichos centros, mejoraría la calidad de los servicios ofertados. (AU)

Sunflower meal as cause of chronic copper poisoning in lambs in southeastern Spain.

Sunflower meal with a copper/molybdenum ratio of 10 caused copper toxicosis in lambs. Copper must be analyzed on a dry matter basis in liver and renal cortex. Oral administration of molybdenum and thiosulfate had a certain effectiveness in sick animals. Care must be taken with feedstuffs made from copper-dependent plants.

Environmental exposure and distribution of lead in four species of raptors in Southeastern Spain.

The purpose of this study was to monitor exposure to lead in four species of raptors in Southeastern Spain (Murcia Region). Samples of liver, kidney, brain, blood, and bone from two species of diurnal raptors (European kestrel (Falco tinnunculus) and European buzzard (Buteo buteo)) and two species of nocturnal raptors (Eagle owl (Bubo bubo) and Little owl (Athene noctua)) were obtained during 1994. Relationships were found between size and age of the birds, the nearness to areas of human activity and lead concentrations in tissues. The lead distribution pattern reveals that the bone is the principle organ for accumulation (0.62-43 mg/Kg, dry weight), followed by the kidney (0.03-0.66 mg/Kg, wet weight), and liver (0. 017-0.05 mg/Kg, w.w.), and to lesser extent, the brain (0.013-0.223 mg/Kg, w.w.). This distribution pattern indicates that raptors in Southeastern Spain were exposed to environmental low lead levels continuously over an extended period of time. Correlations between lead in bone and lead in soft tissues were higher in European buzzards (r = 0.87-0.95) and Eagle owl (r = 0.71-0.86) than those found in European kestrels (r = 0.53-0.58) and Little owls (r << 0). However, correlations between lead concentrations in soft tissues and in blood were high (r = 0.85-0.99).