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1.
Heart Lung ; 42(6): 462-4, 2013.
Article in English | MEDLINE | ID: mdl-23969007

ABSTRACT

Transient hypotension and atrial stunning are known complications of electro-cardioversion for supra-ventricular tachyarrhythmias, however, a clinically significant cardiac failure is extremely rare in this setting. We, herein, present a 77-year-old African American male who underwent electro-cardioversion following an unremarkable transesophageal echocardiogram (TEE) for a symptomatic atrial flutter of a new onset. Immediately post-cardioversion, he suffered severe hypotension with a depressed LV systolic function. IV dobutamine stabilized his blood pressure.


Subject(s)
Atrial Flutter/therapy , Electric Countershock/adverse effects , Shock, Cardiogenic/etiology , Aged , Atrial Flutter/complications , Atrial Flutter/diagnostic imaging , Echocardiography, Transesophageal , Electrocardiography , Humans , Hypotension/etiology , Male
2.
Can J Cardiol ; 29(12): 1741.e5-7, 2013 Dec.
Article in English | MEDLINE | ID: mdl-23890408

ABSTRACT

Cardiac arrhythmias are rarely inducible in patients with hypertrophic cardiomyopathy on provocative manoeuvres to identify latent obstruction. We present a 40-year-old male with history of nonobstructive hypertrophic cardiomyopathy who presented with lightheadedness. Echocardiogram showed severe asymmetric hypertrophy of the left ventricle without left ventricular outflow tract gradient at rest. On Doppler study with Valsalva manoeuvre, he developed symptomatic nonsustained ventricular tachycardia, which was reproduced on repetition. This emphasizes the importance of provocative manoeuvres to unmask potentially significant physiologic manifestations.


Subject(s)
Hypertrophy, Left Ventricular/physiopathology , Tachycardia, Ventricular/physiopathology , Valsalva Maneuver/physiology , Adult , Diagnosis, Differential , Echocardiography , Echocardiography, Doppler , Electrocardiography , Humans , Hypertrophy, Left Ventricular/diagnosis , Male , Tachycardia, Ventricular/diagnosis
3.
Am J Med Sci ; 341(2): 113-8, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21239963

ABSTRACT

INTRODUCTION: A dyshomeostasis of macro- and micronutrients, including vitamin D and oxidative stress, are common pathophysiologic features in patients with congestive heart failure (CHF). In African Americans (AA) with CHF, reductions in plasma 25(OH)D are of moderate-to-marked severity (<20 ng/mL) and may be accompanied by ionized hypocalcemia with compensatory increases in serum parathyroid hormone (PTH). The management of hypovitaminosis D in AA with CHF has not been established. METHODS: Herein, a 14-week regimen: an initial 8 weeks of oral ergocalciferol (50,000 IU once weekly); followed by a 6-week maintenance phase of cholecalciferol (1400 IU daily); and a CaCO3 (1000 mg daily) supplement given throughout was designed and tested. Fourteen AA patients having a dilated (idiopathic) cardiomyopathy with reduced ejection fraction (EF, <35%) were enrolled: all completed the initial 8-week course; and 12 complied with the full 14 weeks. At baseline, 8 and/or 14 weeks, serum 25(OH)D and PTH; serum 8-isoprostane, a biomarker of lipid peroxidation, and echocardiographic EF were monitored. RESULTS: Reduced 25(OH)D at entry (14.4 ± 1.3 ng/mL) was improved (P < 0.05) in all patients at 8 weeks (30.7 ± 3.2 ng/mL) and sustained (P < 0.05) at 14 weeks (30.9 ± 2.8 ng/mL). Serum PTH, abnormally increased in 5 patients at baseline (104.8 ± 8.2 pg/mL), was reduced at 8 and 14 weeks (74.4 ± 18.3 and 73.8 ± 13.0 pg/mL, respectively). Plasma 8-isoprostane at entry (136.1 ± 8.8 pg/mL) was reduced at 14 weeks (117.8 ± 7.8 pg/mL; P < 0.05), whereas baseline EF (24.3 ± 1.7%) was improved (31.3 ± 4.3%; P < 0.05). CONCLUSIONS: Thus, the 14-week course of supplemental vitamin D and CaCO3 led to healthy 25(OH)D levels in AA with heart failure having vitamin D deficiency of moderate-to-marked severity. Albeit a small patient population, the findings suggest that this regimen may attenuate the accompanying secondary hyperparathyroidism and oxidative stress and improve ventricular function.


Subject(s)
Calcium, Dietary/administration & dosage , Heart Failure/drug therapy , Heart Failure/etiology , Vitamin D Deficiency/complications , Vitamin D Deficiency/drug therapy , Vitamin D/administration & dosage , Black or African American , Calcium Carbonate/administration & dosage , Cardiomyopathy, Dilated/blood , Cardiomyopathy, Dilated/diet therapy , Cardiomyopathy, Dilated/drug therapy , Cardiomyopathy, Dilated/etiology , Cholecalciferol/administration & dosage , Dietary Supplements , Dinoprost/analogs & derivatives , Dinoprost/blood , Ergocalciferols/administration & dosage , Female , Heart Failure/blood , Heart Failure/diet therapy , Humans , Hyperparathyroidism, Secondary/blood , Hyperparathyroidism, Secondary/diet therapy , Hyperparathyroidism, Secondary/drug therapy , Hyperparathyroidism, Secondary/etiology , Male , Middle Aged , Parathyroid Hormone/blood , Stroke Volume , Vitamin D/analogs & derivatives , Vitamin D/blood , Vitamin D Deficiency/blood , Vitamin D Deficiency/diet therapy
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