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Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism.

Le Gac, Stéphane; Najjari, Btissam; Motreff, Nicolas; Remaud-Le Saec, Patricia; Faivre-Chauvet, Alain; Dimanche-Boitrel, Marie-Thérèse; Morgenstern, Alfred; Bruchertseifer, Frank; Lachkar, Mohammed; Boitrel, Bernard.

Chem Commun (Camb) ; 47(30): 8554-6, 2011 Aug 14.

Article in English | MEDLINE | ID: mdl-21709892

ABSTRACT

For the first time, α-emitter radioisotope (213)Bi has been incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide. An in situ transmetalation mechanism involving the daughter isotope (209)Pb is expected to boost the (213)Bi radiolabeling process.

Subject(s)

Bismuth/chemistry , Chelating Agents/chemistry , Porphyrins/chemistry , Alpha Particles , Cell Line, Tumor , Coordination Complexes/chemistry , Coordination Complexes/toxicity , Crystallography, X-Ray , Humans , Hydrogen-Ion Concentration , Lead Radioisotopes/chemistry , Molecular Conformation , Radioisotopes/chemistry

Formation of a dinuclear mercury(II) complex with a regular bis-strapped porphyrin following a tunable cooperative process.

Motreff, Nicolas; Le Gac, Stéphane; Luhmer, Michel; Furet, Eric; Halet, Jean-François; Roisnel, Thierry; Boitrel, Bernard.

Angew Chem Int Ed Engl ; 50(7): 1560-4, 2011 Feb 11.

Article in English | MEDLINE | ID: mdl-21308904

Subject(s)

Coordination Complexes/chemistry , Mercury/chemistry , Porphyrins/chemistry , Binding Sites , Crystallography, X-Ray , Dimethyl Sulfoxide/chemistry , Ligands , Molecular Conformation , Nitrogen/chemistry , Oxygen/chemistry

ABSTRACT

Subject(s)

Subject(s)

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