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1.
Dent J (Basel) ; 12(5)2024 May 08.
Article in English | MEDLINE | ID: mdl-38786529

ABSTRACT

Background: Coaxial implants with an inclined neck might overcome some problems related to angulation of the implant axis when using tilted implants. Therefore, the aim of the present work was to conduct a narrative review of the current literature and to present a case series comparing traditional and coaxial external hex implants in full-arch immediate loading rehabilitations of the maxilla. Methods: A total of 13 external hex tapered implants (Southern Implants) was inserted in the upper jaw of 3 patients. Each patient received two tilted implants in distal sites. In one randomly selected quadrant, the tilted implant was a standard implant, while a Co-Axis® implant with a 24° inclination of the implant shoulder was inserted on the other hemi-arch. Straight conical abutments were screwed on coaxial implants while multiunit abutments of appropriate inclination were screwed as needed on the other implants to correct their axes. Peri-implant bone level was recorded radiographically at T0 (delivery of the immediate loading prosthesis), and at 3, 6, 12, and 24 months of healing and then annually. Plaque index, probing depth, and bleeding on probing were also evaluated. Cumulative implant survival rate (CSR) was calculated, and biological or technical complications were recorded as well as the operator satisfaction towards the use of coaxial implants. Results: The preliminary data collected did not show significant differences in peri-implant tissues health and maintenance over time between the two implant types. No implants failed, and both implant types proved to be favorable for full-arch rehabilitation using tilted implants. Coaxial implants facilitated the prosthodontic procedures. However, a learning curve is required in order to optimize their insertion. Conclusions: Both implants proved to be reliable and suitable for achieving clinical success in full-arch immediate loading rehabilitations, but further research with longer follow-up and larger sample size is needed to confirm these preliminary outcomes.

2.
SAGE Open Med Case Rep ; 12: 2050313X241241191, 2024.
Article in English | MEDLINE | ID: mdl-38559405

ABSTRACT

New surgical techniques using narrow, tilted implants positioned through a magneto-dynamic tool in guided surgery for a Toronto restoration. A 69-year-old woman wanted fixed rehabilitation to replace her removable complete dentures. A cone-beam computed tomography showed significant bone resorption in both the maxillary and mandibular regions. The plan was to load the entire upper arch with six implants immediately, while removable partial dentures were recommended for the lower jaw. The guided surgery project was aligned with the new dentures, and the laboratory created a printed cast with dental implant analogues in planned positions. A metal-reinforced denture was constructed, and surgery was performed to place six narrow implants using the magneto-dynamic instrument. The denture was directly screwed onto multi-unit abutments. Final rehabilitation was completed after 6 months. Narrow implants can be a good option for fixed, full-arch rehabilitations. Further research is needed to confirm these findings on a larger scale.

3.
Clin Nutr ESPEN ; 25: 44-49, 2018 06.
Article in English | MEDLINE | ID: mdl-29779817

ABSTRACT

BACKGROUND AND AIMS: Energy requirements are difficult to estimate in children with cerebral palsy (CP). Resting energy expenditure (REE), necessary for personalized nutritional intervention, is most commonly estimated using prediction formulae because the reference method, i.e. indirect calorimetry (IC), is not available in all Nutrition Units. The main aim of the present study was to evaluate the accuracy of the most commonly used REE prediction formulae in children with CP. The secondary aim was to develop a new population-specific formula for the estimation of REE in children with CP. METHODS: REE was measured by IC in 54 children and adolescents with spastic quadriplegic cerebral palsy (SQCP) and estimated from the five most commonly used prediction formulae, i.e. the World Health Organization (WHO), Harris-Benedict, Schofield weight, Schofield weight & height, and Oxford formulae. RESULTS: The mean (standard deviation, SD) difference between the estimated and measured REE was 64 (238) kcal/day for the WHO formula, 79 (226) kcal/day for the Schofield weight formula, 79 (223) kcal/day for the Schofield weight and height formula, 55 (226) kcal/day for the Oxford formula, 37 (224) kcal/day for the Harris-Benedict formula and 0 (213) kcal/day for the purposely developed population-specific formula. Owing to the large SD of the bias, none of these formulae can be reliably applied at the individual level to estimate REE. CONCLUSIONS: The most commonly used REE prediction formulas are inaccurate at both the population and individual level in children with SQCP. A purposely developed population-specific formula, despite being accurate at the population level, does not perform better than the most commonly used REE formulae at the individual level.


Subject(s)
Basal Metabolism , Cerebral Palsy/diagnosis , Child Nutritional Physiological Phenomena , Disabled Children , Malnutrition/diagnosis , Models, Biological , Adolescent , Age Factors , Calorimetry, Indirect , Cerebral Palsy/complications , Cerebral Palsy/physiopathology , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Malnutrition/etiology , Malnutrition/physiopathology , Nutritional Status , Reproducibility of Results , Risk Factors
4.
J Neurosurg Pediatr ; 18(4): 493-498, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27341610

ABSTRACT

OBJECTIVE In this single-center study the authors investigated the complications occurring before and after the introduction of the new Ascenda intrathecal catheter (Medtronic Inc.) in pediatric patients treated with intrathecal baclofen therapy (ITB) for spasticity and/or dystonia. METHODS This was a retrospective review of 508 children who had received ITB, 416 with silicone catheters in the 13 years between September 1998 and September 2011 and 92 with Ascenda catheters in the 3 years between September 2011 and August 2014. The authors evaluated major complications such as infections, CSF leaks treated, and problems related to the catheter or pump, and they compared the 2 groups of patients who had received either a silicone catheter or an Ascenda catheter implant. RESULTS One hundred twenty patients in the silicone group (29%) and 1 patient in the Ascenda group (1.1%; p < 0.001) had a major complication. In the silicone group 23 patients (5.5%) were affected by CSF leakage and 75 patients (18%) experienced 82 catheter-related events, such as occlusion, dislodgment, disconnection, or breakage, which required catheter replacement. In the Ascenda group, only 1 patient (1.1%) was affected by CSF leakage. CONCLUSIONS To the authors' knowledge, this study is the first in the literature to compare the performance of the new Ascenda catheter, introduced in 2011, with the traditional silicone catheter for intrathecal drug infusion. In their analysis, the authors found that the Ascenda catheter can reduce major complications related to the catheter after ITB pump implantation. Further investigation is necessary to expand on and confirm their results.


Subject(s)
Baclofen/administration & dosage , Catheters, Indwelling , Infusion Pumps, Implantable/adverse effects , Injections, Spinal/instrumentation , Muscle Relaxants, Central/administration & dosage , Silicones , Adolescent , Catheters, Indwelling/adverse effects , Cerebrospinal Fluid Leak/etiology , Child , Child, Preschool , Dystonia/complications , Dystonia/drug therapy , Equipment Failure , Female , Humans , Infant , Injections, Spinal/adverse effects , Male , Muscle Spasticity/complications , Muscle Spasticity/drug therapy , Retrospective Studies
5.
Orphanet J Rare Dis ; 9: 208, 2014 Dec 12.
Article in English | MEDLINE | ID: mdl-25497359

ABSTRACT

Current therapies for the Lesch-Nyhan Syndrome (OMIM: 300322) are off-label and experimental, often leading to inconsistent outcomes. We here report the effects of an intrathecal baclofen therapy, carried out at the Scientific Institute Eugenio Medea (Lecco, Italy), on three patients who no longer received benefit from previous therapies. This treatment, as expected, ameliorated the motor symptoms and, unexpectedly, it also improved behavioural components. This result may involve a functional interaction between baclofen and dopamine, complemented by an anxiolytic effect. Our observations provide the rationale for the use of intrathecal baclofen administration in the therapy of the Lesch-Nyhan Syndrome.


Subject(s)
Baclofen/administration & dosage , Lesch-Nyhan Syndrome/drug therapy , Motor Skills Disorders/drug therapy , Self-Injurious Behavior/drug therapy , Adult , Behavioral Symptoms/complications , Behavioral Symptoms/diagnosis , Behavioral Symptoms/drug therapy , Humans , Lesch-Nyhan Syndrome/complications , Lesch-Nyhan Syndrome/diagnosis , Male , Motor Skills Disorders/complications , Motor Skills Disorders/diagnosis , Self-Injurious Behavior/complications , Self-Injurious Behavior/diagnosis , Treatment Outcome , Young Adult
6.
J Neurosurg Pediatr ; 13(3): 301-6, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24404968

ABSTRACT

OBJECT: This single-center study investigated adverse events that occurred in children and adolescent patients treated with intrathecal baclofen (ITB) therapy for spasticity and/or dystonia. METHODS: In a 14-year period, 430 consecutive patients with a mean age of 13.3 ± 5.9 years received ITB over a mean follow-up period of 8.6 ± 3.8 years (range 12 months to 14 years). Eighty-nine percent of these patients had cerebral palsy. Major complications, defined as those that required a surgical intervention, were infections, CSF leaks, and device problems related to the catheter or pump. Assessing infections, the authors compared the 2 groups of patients implanted with an ITB system by either the subcutaneous or subfascial technique. The temporal distribution of events related to the catheter was also considered. RESULTS: At least 1 complication was present in 25% of the patients: 9.3% experienced an infection, 4.9% a CSF leak, 15.1% a problem with the catheter, and 1% a problem related to the pump. Five percent of the assessed patients suffered more than 1 complication. The rate of infections was significantly lower (p < 0.001) in patients with the pump placed subfascially compared with those with the pump placed subcutaneously. A higher rate of infection was found after pump replacement compared with the first pump implantation (10.6% vs 6%, respectively). Catheter problems were the most common complication and occurred more frequently during the 1st year after the implant. CONCLUSIONS: While ITB is an effective treatment to manage spasticity of different origins, adverse events may occur and need to be managed. The surgical procedure should be meticulous and different techniques may have a diverse impact on the infection rate, which is the most critical complication. Despite the adverse events that occurred in this study, the majority of patients were satisfied with the treatment received.


Subject(s)
Baclofen/adverse effects , Catheters, Indwelling/adverse effects , Cerebral Palsy/complications , Infections/etiology , Infusion Pumps, Implantable/adverse effects , Muscle Relaxants, Central/adverse effects , Muscle Spasticity/drug therapy , Adolescent , Baclofen/administration & dosage , Cerebral Palsy/physiopathology , Child , Child, Preschool , Dystonia/chemically induced , Dystonia/drug therapy , Dystonia/etiology , Dystonic Disorders/chemically induced , Dystonic Disorders/drug therapy , Dystonic Disorders/etiology , Female , Follow-Up Studies , Humans , Infant , Injections, Spinal/adverse effects , Kaplan-Meier Estimate , Male , Muscle Relaxants, Central/administration & dosage , Muscle Spasticity/etiology , Retrospective Studies , Treatment Outcome
7.
Eur Spine J ; 22 Suppl 6: S803-7, 2013 Nov.
Article in English | MEDLINE | ID: mdl-24052405

ABSTRACT

PURPOSE: The purpose of this study is to present a large consecutive series of pediatric patients affected by neuromuscular scoliosis treated with Unit Rod instrumentation. METHODS: Retrospective review of 160 children treated with Unit Rod instrumentation between 2003 and 2010. This review analyzed complications, radiographic outcome, time surgery, average blood loss, hospital staying and functional outcome of patients and parents after surgery. The follow-up of 80 patients is at more than 5 years. RESULTS: Scoliosis was corrected from a mean of 56° range 21° to 76° Cobb (68 %). Pelvic obliquity was corrected from a mean of 24° to 5° (74 %). Major complications are not related to the technique but to the pathology. CONCLUSION: Unit Rod instrumentation is a common standard technique, is considerably less expensive than the other system, and remains a good indication for the treatment of the spinal deformity in children affected by neuromuscular disease.


Subject(s)
Internal Fixators , Neuromuscular Diseases/pathology , Scoliosis/pathology , Scoliosis/surgery , Spinal Fusion/instrumentation , Spinal Fusion/methods , Adolescent , Child , Female , Humans , Length of Stay , Male , Retrospective Studies , Treatment Outcome , Young Adult
8.
Neurol Sci ; 32 Suppl 3: S341-3, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21915650

ABSTRACT

In this article, we analysed the orthopaedic malformation in patients affected by Chiari I malformations as well as conservative or surgical treatment. The most common deformity in these patients is scoliosis. Different studies suggest a causal relation between syringomyelia and spinal deformities that differ by the type of deformities: asymptomatic scoliosis is characterized by a higher incidence of a single curve and convexity to the left, while symptomatic scoliosis is characterized by a double thoracolumbar curve. The conservative treatment with brace in these patients is not effective and scoliosis is typically evolutive. The evidence of the international data is that in patients without myelomeningocele or congenital scoliosis, but with Arnold Chiari I malformation and syringomyelia, suboccipital craniectomy gives the best chance for syrinx reduction and scoliosis improvement, particulary in children younger than 10 years and below a Cobb angle of 30°. The orthopaedic treatment in late decompression or in progressive curve is spine arthrodesis.


Subject(s)
Arnold-Chiari Malformation/complications , Arnold-Chiari Malformation/surgery , Nervous System Diseases/etiology , Scoliosis/etiology , Databases, Bibliographic/statistics & numerical data , Decompression, Surgical , Disease Progression , Humans , Longitudinal Studies , Magnetic Resonance Imaging , Orthopedics , Tomography, X-Ray Computed , Treatment Outcome
9.
Dev Med Child Neurol ; 53(5): 443-8, 2011 May.
Article in English | MEDLINE | ID: mdl-21480874

ABSTRACT

AIM: The aim of this retrospective analysis was to determine the impact of intrathecal baclofen (ITB) therapy on motor function in patients with cerebral palsy (CP). METHOD: We studied 37 patients (18 males, 19 females) with CP treated with ITB (mean age at implant 13 y 7 mo, SD 7 y). Eighteen patients were affected by spastic diplegia, 12 by spastic quadriplegia, six by dystonic quadriplegia, and one by hemidystonia. Nine participants were in Gross Motor Function Classification System (GMFCS) level II, 13 in level III, seven in level IV, and eight in level V. Motor function was assessed by the Gross Motor Function Measure (GMFM) before the treatment and 12 months after the implant. RESULTS: The collected data showed an increase in the total median GMFM score in the overall population (p<0.001) and in every GMFM dimension (p<0.05) except for dimension D (standing). The analysis by degree of impairment revealed that patients with severe impairment and those with mild to moderate impairment improved the total median GMFM score (p<0.001 and p<0.05 respectively). Analysis by age showed that the best improvements in GMFM scores were reached by patients younger than 18 years old (p<0.05). Spasticity and dystonia, assessed by means of the Ashworth and Barry-Albright Dystonia scales, significantly decreased 12 months after the implant (p<0.001 and p<0.05 respectively). Finally, a subjective questionnaire administered to patients/caregivers revealed an overall improvement in participants' functional abilities. INTERPRETATION: The results suggest that ITB therapy is an effective treatment for managing spasticity and dystonia, and for improving motor function in children with CP.


Subject(s)
Baclofen/therapeutic use , Cerebral Palsy/complications , GABA-B Receptor Agonists/therapeutic use , Movement Disorders/drug therapy , Movement Disorders/etiology , Adolescent , Adult , Age Factors , Cerebral Palsy/classification , Child , Child, Preschool , Disability Evaluation , Female , Follow-Up Studies , Humans , Injections, Spinal/methods , Male , Retrospective Studies , Severity of Illness Index , Surveys and Questionnaires , Young Adult
10.
J Pediatr Orthop ; 30(6): 582-7, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20733424

ABSTRACT

BACKGROUND: Forced use (FU) is an emerging treatment for children with hemiplegic cerebral palsy (CP). It involves constraining the unaffected arm and no additional treatment of the affected arm. Our study examined a new approach to FU in children with hemiplegic CP: that is, restraint of the unaffected limb and no rehabilitation. METHODS: Ten children with hemiplegic CP aged between 5 and 9 years were compared with 10 control children (aged between 5 and 8 y). All participants were classified as MACS level II.The FU group wore a fixed cast, on the unaffected arm for 21 consecutive days, and, such as the control group, did not receive any physical therapy.All participants were assessed by the Melbourne Assessment of Unilateral Upper Limb Function and the Shriners Hospital Upper Extremity Evaluation. RESULTS: A statistically significant increase in both the functional scales was already apparent after cast removal and was maintained during follow-ups. The total Melbourne Assessment of Unilateral Upper Limb Function percentage score increased significantly to 9.5% and 12.3% on 3-week and 3-month follow-up examinations, respectively (P<0.05). A statistically significant increase was observed in 2 of the 3 parts of the Shriners Hospital Upper Extremity Evaluation: spontaneous use (P<0.05) and the ability of the involved limb to grasp and release (G/R) (P<0.05). CONCLUSIONS: These preliminary results suggest that FU without rehabilitation improves the spontaneous use and function of the affected upper limb. In children with hemiplegia, this approach may be an economically viable means of upper limb treatment that has no side effects. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions to Authors for complete description of level of evidence.


Subject(s)
Cerebral Palsy/rehabilitation , Hemiplegia/rehabilitation , Immobilization/methods , Case-Control Studies , Cerebral Palsy/physiopathology , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Upper Extremity/physiopathology
11.
Eur J Paediatr Neurol ; 14(1): 19-28, 2010 Jan.
Article in English | MEDLINE | ID: mdl-19541514

ABSTRACT

Among features of motor disorders in children, spasticity is associated with considerable morbidity and problems in care, particularly in severely affected patients. Intrathecal baclofen (ITB) has been increasingly used as a relatively specific treatment modality for spasticity. To date, most of the evidence for its use in paediatric patients has come from retrospective and uncontrolled studies, although randomised, controlled trials of screening ITB and ITB therapy itself have recently been published. This consensus statement on the use of ITB in paediatric patients with spasticity was developed on the basis of currently available evidence, with the aim of providing information for clinicians, promoting an expert opinion and a consistent approach to the management of these patients and emphasising the need for further prospective, large-scale studies.


Subject(s)
Baclofen/therapeutic use , Consensus , Muscle Relaxants, Central/therapeutic use , Muscle Spasticity/drug therapy , Pediatrics , Guidelines as Topic , Humans , Injections, Spinal/methods
12.
J Pediatr Orthop ; 29(7): 817-21, 2009.
Article in English | MEDLINE | ID: mdl-20104168

ABSTRACT

BACKGROUND: Different studies show the efficacy of intrathecal baclofen therapy (ITB) in patients with secondary dystonia because of cerebral palsy. These studies only report improvements related to dystonia reduction; however, none of them have assessed whether such benefit is reflected in limb function. The purpose of our study is to determine whether the effects ITB therapy in patients with secondary dystonia to cerebral palsy, in addition to reducing dystonia, may also improve upper limb function. METHODS: Eleven patients with secondary dystonia, classified as levels 3 and 4 of the Gross Motor Function Classification System, were treated with ITB. The mean age at implant was 11.3 (SD+/-3.02) years.Before treatment and 12 months after implant, the patients were evaluated by the Melbourne Assessment of Unilateral Upper Limb and the Barry Albright scale to assess upper limb function and dystonia, respectively. RESULTS: We found a statistically significant improvement in both scales. The Melbourne scale total percentage score, for both limbs, increased in all patients (P<0.05). Dystonia assessed by the Barry Albright scale scale decreased significantly by 15% from baseline to 12 months follow-up (P<0.05). CONCLUSIONS: In patients with secondary dystonia treated with ITB, functional improvement of the upper limbs was observed in addition to dystonia reduction. In patients with secondary dystonia, ITB is a treatment that aims to achieve a general reduction of dystonia; this study want to show the influence that this reduction has to functional ability of patient. LEVEL OF EVIDENCE: Therapeutic study: level 4.


Subject(s)
Arm/physiopathology , Baclofen/therapeutic use , Cerebral Palsy/complications , Cerebral Palsy/drug therapy , Dystonic Disorders/drug therapy , Muscle Relaxants, Central/therapeutic use , Baclofen/administration & dosage , Cerebral Palsy/physiopathology , Child , Disability Evaluation , Dystonic Disorders/etiology , Dystonic Disorders/physiopathology , Female , Humans , Injections, Spinal , Male , Muscle Relaxants, Central/administration & dosage , Severity of Illness Index , Statistics, Nonparametric , Treatment Outcome
13.
J Pediatr Orthop ; 28(2): 213-7, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18388717

ABSTRACT

BACKGROUND: The literature available shows that spasticity in patients with cerebral palsy (CP) is reduced by intrathecal baclofen (ITB) treatment, and various studies suggest that this treatment can also be used in dystonic patients. The aim of the present study was to evaluate dystonia treated with ITB in children with CP. METHODS: Data of 19 patients affected by dystonia as an outcome of infant CP in patients belonging to level V of Gross Motor Function Classification System treated with ITB were collected. The mean age at implant is 8.49 years.The patients are assessed using Barry-Albright Scale and Burke-Fahn-Marsden Scale before treatment and at 3, 6, and 12 months postimplant. RESULTS: The results showed a statistically significant improvement (P < 0.001) in the total scores of the 2 scales after just 3 months of treatment, an improvement that was maintained for the 1-year period of follow-up. The results also revealed a reduction in dystonias, an improvement in posture, and an easing of the task of the caregivers in managing the patient as a result of treatment with ITB. CONCLUSIONS: In patients belonging to level V of Gross Motor Function Classification System and treated with ITB, a decrease in frequency and severity of dystonia is observed. This improvement eases caregiver in patient management. LEVEL OF EVIDENCE: Therapeutic Level IV.


Subject(s)
Baclofen/administration & dosage , Cerebral Palsy/drug therapy , Dystonia/drug therapy , Muscle Relaxants, Central/administration & dosage , Adolescent , Caregivers , Cerebral Palsy/complications , Child , Child, Preschool , Disability Evaluation , Dystonia/etiology , Female , Follow-Up Studies , Humans , Infusion Pumps, Implantable , Injections, Spinal , Male , Severity of Illness Index , Surveys and Questionnaires
14.
J Pediatr Orthop ; 28(1): 91-6, 2008.
Article in English | MEDLINE | ID: mdl-18157052

ABSTRACT

BACKGROUND: The literature shows that intrathecal baclofen (ITB) treatment in patients with cerebral palsy (CP) is able to reduce spasticity. The purpose of this work is to evaluate the motor function of the upper limbs in patients with CP treated with ITB. METHODS: A consecutive series of 20 patients with spastic CP (mean age at implant, 11.4 years) implanted with pumps in our center was studied. These patients were classified using the Gross Motor Function Classification System. The patients were followed up over a 12-month period for assessment of the upper limb function with the Melbourne Assessment of Unilateral Upper Limb Function scale. RESULTS: The data show a reduction of upper limb spasticity in all 20 patients (P < 0.05). The Melbourne scale shows a statistically significant improvement of the total score (P < 0.05) and an improvement of the subskills of range of movement, target accuracy, and fluency. Twenty-five percent of patients showed a clinically significant improvement. CONCLUSION: The subjects with CP of different degrees of severity had an improvement in the quality of the upper limb function and showed overall satisfaction with the results achieved. The study also shows the importance of evaluating the quality of upper limb function in children with CP treated with ITB therapy.


Subject(s)
Baclofen/administration & dosage , Cerebral Palsy/drug therapy , Muscle Relaxants, Central/administration & dosage , Range of Motion, Articular/physiology , Upper Extremity/physiopathology , Adolescent , Cerebral Palsy/physiopathology , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infusion Pumps, Implantable , Injections, Spinal/instrumentation , Male , Retrospective Studies , Treatment Outcome
15.
J Neurosurg ; 107(1 Suppl): 32-5, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17644918

ABSTRACT

OBJECT: The authors investigated the efficacy of intrathecal baclofen therapy, analyzing the complications and risk factors in 200 consecutive patients who received pump implants. METHODS: The patient population included 200 patients (mean age 13.7 +/- 5.68 years). The follow-up duration varied from 13.07 to 87.50 months (mean 50.71 months). RESULTS: The mean Ashworth Scale, Barry-Albright Dystonia Scale, clonus, and spasm scores decreased postoperatively. Overall, 31% of patients experienced complications as follows: 11% had cerebrospinal fluid leakage, 7% had catheter-related problems, 7.5% suffered infections; 5.5% of patients had more than one complication. CONCLUSIONS: The authors found that the onset of at least one complication is statistically more likely in patients with Ashworth Scale scores higher than 3 and an age of 10 years or younger. A reduction in the incidence of infection from 10 to 4.8% by the end of the study period appears to be correlated with the switch in technique to subfascial instead of subcutaneous pump implantation and the adoption of a new preoperative prophylaxis protocol in the last 51 patients. There were no statistically significant correlations between the onset of complications and patient weight, ambulatory status, or the presence of dystonia or cerebral palsy.


Subject(s)
Baclofen/administration & dosage , Cerebral Palsy/drug therapy , Infusion Pumps, Implantable , Muscle Relaxants, Central/administration & dosage , Spinal Cord/drug effects , Adolescent , Baclofen/adverse effects , Child , Child, Preschool , Female , Humans , Injections, Spinal , Italy , Male , Muscle Relaxants, Central/adverse effects , Muscle Spasticity/drug therapy , Outcome and Process Assessment, Health Care , Postoperative Complications/etiology , Postoperative Complications/prevention & control , Retrospective Studies , Treatment Outcome
16.
J Child Neurol ; 20(8): 661-6, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16225811

ABSTRACT

Botulinum toxin A is widely used for spasticity management in children with cerebral palsy, although outcomes are unpredictable. The aim of this study was to identify criteria for selecting patients most likely to benefit from botulinum toxin A treatment. Fifty-five subjects, aged 2.5 to 18 years, were recruited. The assessment covered measures of spasticity (Modified Ashworth Scale), function (using the Gross Motor Function Measure and the Physician's Rating Scale), selective motor control, static range of motion at the ankle with knee extended and flexed, range of motion of the knee flexors, central and peripheral vision, and cognitive ability. Outcomes at 3 months were compared with baseline values. All of the scales showed significant differences between pre- and postinjection values. Significantly increased Gross Motor Function Measure scores were found in children aged 48 months or under and in those able to walk with support. Greater improvements in selective motor control and Physician's Rating Scale were seen in those with a less severe pattern of paralysis, lower levels of impairment, the ability to walk (with or without support), normal visual acuity, and normal or borderline cognition. We identified factors that mark out patients as most likely to achieve functional gains: young age, hemiplegia or diplegia, slight to moderate disability, walking with support, normal or borderline cognition, and normal or borderline visual acuity.


Subject(s)
Botulinum Toxins, Type A/therapeutic use , Cerebral Palsy/complications , Muscle Spasticity/drug therapy , Muscle Spasticity/etiology , Neuromuscular Agents/therapeutic use , Adolescent , Age Factors , Cerebral Palsy/rehabilitation , Child , Child, Preschool , Cognition , Disabled Persons , Female , Hemiplegia , Humans , Male , Motor Skills , Predictive Value of Tests , Prognosis , Range of Motion, Articular , Severity of Illness Index , Treatment Outcome , Visual Acuity , Walking
17.
Pediatr Neurol ; 33(2): 110-3, 2005 Aug.
Article in English | MEDLINE | ID: mdl-16087055

ABSTRACT

The objective of this study was to analyze the relationship between epilepsy and intrathecal baclofen by investigating a consecutive sample of 150 children with cerebral palsy or spasticity of cerebral origin who underwent intrathecal baclofen. The medical charts of the 150 children were retrospectively reviewed. A series of 100 children with cerebral palsy, operated on other procedures, was reviewed as a control group. Forty percent of the 150 children had epilepsy before intrathecal baclofen pump implantation; 13.3% had a decrease in seizure frequency after intrathecal baclofen, while two children worsened and one child had seizures ex novo. We conclude that in children with spasticity of cerebral origin, intrathecal baclofen does not seem to aggravate or induce seizure activity.


Subject(s)
Baclofen/administration & dosage , Cerebral Palsy/complications , Cerebral Palsy/drug therapy , Epilepsy, Generalized/complications , Muscle Relaxants, Central/administration & dosage , Baclofen/adverse effects , Child, Preschool , Epilepsy, Generalized/chemically induced , Humans , Infant , Infusion Pumps, Implantable , Injections, Spinal , Muscle Relaxants, Central/adverse effects , Muscle Spasticity/complications , Muscle Spasticity/drug therapy , Retrospective Studies
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