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Maturitas ; 51(4): 370-9, 2005 Aug 16.
Article in English | MEDLINE | ID: mdl-16039410

ABSTRACT

OBJECTIVE: The purpose of this study was to evaluate the effects of two sex hormones on normal mammary gland of female rats. METHODS: Forty 250-day-old female rats, 20 of them with offspring and 20 not, were ovariectomized and, divided into 4 subgroups in order to receive one of the following subcutaneous treatment: estradiol benzoate (EB), medroxyprogesterone (MPA), EB+MPA or placebo, for 10 weeks. After treatment, mammary glands were studied with optical microscope. Whole gland, lobule, ductule and lumen compartments were evaluated by morphometric methods. Also a qualitative evaluation were performed seeking for secretion, microcalcification and trophic status. RESULTS: It was found that (a) MPA-only and placebo were similar for all parameters; (b) the same between EB and EB+MPA; (c) EB and EB+MPA increased lobule, ductule and lumen compartments significantly compared to MPA-only or placebo; (d) EB increased epithelium but without significance and EB+MPA increased it significantly compared to placebo or MPA; (e) EB and EB+MPA incremented secretion. CONCLUSIONS: In normal mammary gland of female rats: progestin action depends on estrogen presence. MPA does not revert estrogen-dependent proliferation, but it magnifies estradiol effect. Both EB and EB+MPA stimulate differentiation. Rats without offspring presented a greater epithelial proliferation under treatment with these sex hormones.


Subject(s)
Estradiol/analogs & derivatives , Mammary Glands, Animal/drug effects , Medroxyprogesterone/pharmacology , Animals , Case-Control Studies , Cell Proliferation/drug effects , Estradiol/administration & dosage , Estradiol/pharmacology , Female , Linear Models , Mammary Glands, Animal/pathology , Medroxyprogesterone/administration & dosage , Random Allocation , Rats , Rats, Wistar
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