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1.
Toxicol Lett ; 18(1-2): 153-6, 1983 Aug.
Article in English | MEDLINE | ID: mdl-6623540

ABSTRACT

The effects of vitamin C on acute paracetamol poisoning were studied in mice. Given orally at 50, 100 or 200 mg/kg, either simultaneously or 2 h after the oral administration of 875 mg/kg of paracetamol, vitamin C did not cause any decrease in the mortality rate. In similar conditions in previous experiments methionine and cysteine were shown to be very effective antidotes.


Subject(s)
Acetaminophen/poisoning , Ascorbic Acid/pharmacology , Acute Disease , Animals , Female , Male , Mice , Mice, Inbred Strains
2.
Toxicology ; 3(2): 207-11, 1975.
Article in English | MEDLINE | ID: mdl-1124537

ABSTRACT

Acetylsalicylic acid (ASA) administration (200 mg/kg/day) during the last six days of pregnancy in the rat has been observed to result in: (a) a prolongation of the duration of pregnancy; (b) a prolongation of the parturition time; (c) the appearance, in some individuals, of dystocia with possible secondary death of foetuses in utero.


Subject(s)
Aspirin/pharmacology , Animals , Animals, Newborn , Behavior, Animal/drug effects , Body Weight/drug effects , Female , Fetal Death , Pregnancy , Prenatal Care , Rats , Rats, Inbred Strains , Time Factors
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