ABSTRACT
We made a comparative survey of the poliovirus antibodies (anti-poliovirus type 1, anti-poliovirus type 2 and anti-poliovirus type 3) and the measles antibodies in malnourished but completely vaccinated children (37) and control children (34). The age range was 10 months to 5 years. Immunization in children with protein-energy malnutrition was low for both vaccines. Seroprevalence rates of the polio 1, polio 2, polio 3 antibodies and the measles antibodies in the control group were 94.1%, 97.1%, 91.2% and 82.4% respectively. In malnourished children the respective rates were in some cases significantly lower being: 40.5% (P = 0.001), 59.5% (P = 0.001), 40.5% and 35.1%. Malnutrition is a major determinant of the humoral response to oral polio and measles vaccines and must be given due consideration to prevent vaccination failure.
Subject(s)
Child Nutrition Disorders/complications , Measles/prevention & control , Poliomyelitis/prevention & control , Protein-Energy Malnutrition/complications , Vaccination/standards , Age Distribution , Antibodies, Viral/blood , Antibody Formation , Case-Control Studies , Child , Child Nutrition Disorders/blood , Child Nutrition Disorders/immunology , Child, Preschool , Female , Humans , Immunization Schedule , Infant , Male , Measles/complications , Measles/epidemiology , Measles virus/immunology , Morocco/epidemiology , Poliomyelitis/complications , Poliomyelitis/epidemiology , Poliovirus/immunology , Protein-Energy Malnutrition/blood , Protein-Energy Malnutrition/immunology , Seroepidemiologic Studies , Sex Distribution , Treatment FailureABSTRACT
We made a comparative survey of the poliovirus antibodies [anti-poliovirus type 1, anti-poliovirus type 2 and anti-poliovirus type 3] and the measles antibodies in malnourished but completely vaccinated children [37] and control children [34].The age range was 10 months to 5 years. Immunization in children with protein-energy malnutrition was low for both vaccines. Seroprevalence rates of the polio 1, polio 2, polio 3 antibodies and the measles antibodies in the control group were 94.1%, 97.1%, 91.2% and 82.4% respectively. In malnourished children the respective rates were in some cases significantly lower being: 40.5% [P = 0.001], 59.5% [P = 0.001], 40.5% and 35.1%. Malnutrition is a major determinant of the humoral response to oral polio and measles vaccines and must be given due consideration to prevent vaccination failure
