Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation.

Spinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical organization and physiology of the autonomic nervous system (ANS), elucidating how SCI impacts its function, with a particular focus on lymphoid organs and immune activity. We highlight recent advances in understanding how intraspinal plasticity that follows SCI may contribute to aberrant autonomic activity in lymphoid organs. Additionally, we discuss how sympathetic mediators released by these neuron terminals affect immune cell function. Finally, we discuss emerging innovative technologies and potential clinical interventions targeting the ANS as a strategy to restore the normal regulation of the immune response in individuals with SCI.

Doenças crônicas na infância: remédios análise de alguns recursos terapêuticos / Chronic grave in the childhood

Pretende discutir o potencial, pouco explorado, de práticas e ralações médico-social, no tratamento de crianças com doenças crônicas graves e, freqüente, fatais. Ressalta a qualidade da relação médico/cliente(paciente-pais), a busca de sentido, a percepção da doença pelo paciente, sua família e a equipe de saúde do hospital, a fé na cura e a solidariedade. Visamos observar aproximaçoes e distanciamentos entre a demanda dafamília e as possibilidades de oferta do serviço de saúde. estas reflexões se baseiam na experiência profissional no Instituto Fernandes Figueira, hospital materno-infantil, público, terciário, da FIOCRUZ/Ministério da Saúde