ABSTRACT
Gestation in sheep necessitates the support of nutrients to avoid early embryonic mortalities. Therefore, this study investigates the effects of supplementing either L-arginine or Spirulina alga in the first trimester on the pregnancy rate, litter size, inhibin, insulin, IGF-I, CO Q10, and bone morphogenetic peptide 15 (BMP15) in maternal circulation. Animals were offered barley (500 g/head/day, 14% CP), alfalfa hay (1 kg/head/day, 12% CP), clean water, and balanced salt block licks as free choices. Forty Noemi and Najdi ewes were randomly allotted into three groups: control (C, n = 8), L-arginine (ARG, n = 16), and Spirulina (SP, n = 16). All females were implanted with CIDR for ten days. On days 8, 9, and 10, treated ewes were given a protocol comprised of human recombinant FSH at descending doses (50, 50, 40, 40, and 30, 30 IU, A.M, and P.M, respectively). At the fifth dose, animals were given an equivalent dose of hCG (240 IU). After CIDR withdrawal, ewes were exposed to fertile rams for mating. SP-ewes were orally given 50 ml (2%) Spirulina, and ARG-ewes were given 50 ml (35 mg/kg BW) L-arginine daily for 50 days postbreeding. Blood inhibin, insulin, IGF-I, CO Q10, and BMP15 were determined throughout gestation until parturition. The findings indicated that the conception rates were 25, 75, and 87.5% in C, ARG, and SP, respectively (P < 0.05). The percent of ewes giving birth to twins was 0, 25, and 50% in C, ARG, and SP, respectively (P < 0.05). The survival rates were 100, 81.8, and 83.3%, respectively. Birth weight was 5.6, 3.2, and 3.4 kg in C, ARG, and SP, respectively. Weaning weights were 28.3, 25.6, and 27.2 kg in C, ARG, and SP, respectively. BMP-15 was reduced (P < 0.05) in ARG than in C and SP. However, SP decreased (P < 0.05) inhibin more than in C and ARG. ARG and SP increased (P < 0.05) insulin than in C, whereas SP decreased (P < 0.05) IGF-I. SP increased CO Q10 compared with ARG. Ewes bearing twins revealed higher (P < 0.05) IGF-I (8.57 ng/ml) than those bearing singles (4.63 ng/ml); however, BMP-15 was higher in single (796.6 pg/ml) than in twin-bearing (387.5 pg/ml) ewes. In conclusion, providing early-gestating ewes with Spirulina enhances maternal health, productivity, and reproductive outcomes.
ABSTRACT
Self-inserted urethral foreign bodies (FBs) are rare. Neither reported case was the self-inflicted FB due to a lack of financial resources nor was either case complicated by Fournier's gangrene. We present a 54-year-old male who inserted a household pipe to relieve his urine retention. Unfortunately, the FB became stuck inside, perforated the urethra, and required perineal exploration. After it was removed, the urethra was closed over a 16F urethral catheter. The wound was complicated by severe infection and resulting Fournier's gangrene. This required an additional surgery for debridement and urine diversion. Retrospectively, it would have been better if the urethra had been left open with SP tube only. We are sharing a clinical lesson learned by the practicing urologist and surgeons. Conclusively, self-inserted FBs in the urethra may lead to a series of complications. Patients with limited financial resources need more attention and care because they may hurt themselves unintentionally.
ABSTRACT
A giant prostatic hyperplasia (GPH) weighing more than 700 g is a rare entity. It is believed that only eight such cases have been previously reported in the medical literature. This case report concerns a patient with a GPH weighing 740 g which was successfully removed by suprapubic prostatectomy. To our knowledge, this is the fourth largest benign prostatic enlargement ever reported in the literature.
ABSTRACT
INTRODUCTION: Paediatric head and neck malignancy accounts for 5% of all paediatric cancers. The choice of treatment and prediction of prognosis depend on the histological type of tumour, initial staging, evaluating treatment response and detection of early recurrence. Conventional imaging modalities have many limitations. Positron emission tomography/computed tomography (PET/CT) is more accurate; however, so far, the literature lacks reports of large groups of paediatric patients. AIM: To report the role of PET/CT in factors affecting the choice of treatment at the newly established Children Cancer Hospital in Cairo, Egypt, which is one of the busiest dedicated paediatric oncology centres in the world. All findings were proven by histopathology, radiology and by clinical follow-up. PATIENT POPULATION: Thirty-six paediatric patients (30 boys and six girls) with various histologically proven head and neck cancers were included in this study. Their age ranged from 2 to 17 years. High-resolution diagnostic CT and/or MRI of the head and neck, and in relevant cases also of the chest and the abdomen, were performed in all patients at a mean interval of 1.6 weeks (range, 1-3 months) before the PET/CT study. Results of PET/CT were compared with the findings of these conventional imaging modalities. RESULTS: The sensitivity, specificity, accuracy, positive and negative predictive values of PET/CT against the conventional imaging were as follows: sensitivity 100 and, 53%, specificity 89.5 and 47%, accuracy 94.5 and 50%, positive predictive value 89.5 and 47% and negative predictive value 100 and 53% respectively. PET/CT changed patient management in 50% of the cases. CONCLUSION: PET/CT in paediatric head and neck carcinoma is more accurate than conventional imaging. Therefore, it also has a significant impact on further patient management. We recommend that it should be the first imaging modality for all purposes in initial staging, evaluating treatment response and follow-up in paediatric head and neck carcinoma.
