Subject(s)
Anti-Bacterial Agents/adverse effects , Clarithromycin/adverse effects , Confusion/chemically induced , Hallucinations/chemically induced , Mental Disorders/chemically induced , Rosacea/drug therapy , Sleep Wake Disorders/chemically induced , Adult , Anti-Bacterial Agents/therapeutic use , Clarithromycin/therapeutic use , Confusion/diagnosis , Dose-Response Relationship, Drug , Female , Hallucinations/diagnosis , Humans , Mental Disorders/diagnosis , Sleep Wake Disorders/diagnosis , SyndromeSubject(s)
Alopecia/diagnosis , Alopecia/drug therapy , Estradiol/analogs & derivatives , Estradiol/therapeutic use , Administration, Topical , Aged , Estrogens/therapeutic use , Female , Follow-Up Studies , Humans , Menopause , Middle Aged , Patient Satisfaction , Prospective Studies , Treatment OutcomeABSTRACT
Hereditary epidermolysis bullosa (HEB) is a group of genetically determined mechanobullous disorders characterized by blister formation following minor trauma. Unusual melanocytic lesions may be a rare feature of all major categories of HEB. We report a large melanocytic nevus, clinically simulating malignant melanoma, which developed at a site of healing blisters in an 8-year-old male with recessive generalized epidermolysis bullosa simplex (EBS). Histological findings were consistent with a compound nevus. This is the third reported case of an eruptive melanocytic nevus developing in EBS. Due to their unique features, it has been suggested that these nevi may represent a distinct variant, referred to as epidermolysis bullosa nevi. Despite the atypical picture, no malignant transformation of HEB nevi has been seen. Therefore, after histologic verification, regular long-term follow-up rather than radical surgery is recommended.
