Age density patterns in patients medical conditions: A clustering approach.

This paper presents a data analysis framework to uncover relationships between health conditions, age and sex for a large population of patients. We study a massive heterogeneous sample of 1.7 million patients in Brazil, containing 47 million of health records with detailed medical conditions for visits to medical facilities for a period of 17 months. The findings suggest that medical conditions can be grouped into clusters that share very distinctive densities in the ages of the patients. For each cluster, we further present the ICD-10 chapters within it. Finally, we relate the findings to comorbidity networks, uncovering the relation of the discovered clusters of age densities to comorbidity networks literature.

Analysis of the Existence of Patient Care Team Using Social Network Methods in Physician Communities from Healthcare Insurance Companies.

Care teams are formed by physicians of different specialties who take care of the same patient. Hence, if we find physicians that share patients with each other probably they configure an informal care team. Thus, the objective of this work is to explore the possibility of finding care teams using Social Network Analysis techniques in physician-physician networks where the physicians have patients in common. For this, we used healthcare insurance claims to build the network. There was the agreement on the metrics of degree and eigenvalue and of betweenness and closeness, also physicians with the 5 highest eigenvalues are highly interconnected. We discuss that the analysis of the physician-physician network with metrics of centrality is promising to reveal informal care teams. The high potential in calculating these metrics is verified from the results to evaluate member's performance and with that how to take actions to improve the work of the team.

Análise do relacionamento na comunidade de médicos de seguradoras de saúde / Relationship analysis in the physician community from healthcare insurance companies / Análisis del relacionamiento en la comunidad médica de las compañías de seguro médico

O objetivo é analisar os relacionamentos entre médicos que possuem pacientes em comum a partir de sinistros de seguradora de saúde. Utilizou-se a técnica de analítica de grafos para modelar os relacionamentos e foram calculadas métricas de centralidades para encontrar a importância relativa dos médicos. Houve a concordância das métricas de grau e auto valor e de betweenness e closeness (10% a 15% no top 100 médicos). Além disso, os 5 médicos com maior valor na métrica de auto valor estão altamente conectados entre si. Conclui-se que as métricas captaram o relacionamento entre os médicos desta comunidade que coincidem com a literatura indicando que é possível encontrar médicos que colaboram entre si no cuidado do paciente dentro e fora do hospital. Além disso, os médicos de maior auto valor indicam que são referência para outros médicos e médicos que estão conectados com muitos outros sugerem que estes influenciam nas decisões de seus pacientes.

The aim of this work is to analyze the relationship between physicians from a health insurance company,who attend the same patient. We use graph analytics to model the physician's relationship. Centrality metrics were calculated to find the relative importance of the physicians. There was the agreement on the metrics of degree and eingenvalue and of betweenness and closeness (10% to 15% in the top 100 physicians). In addition, physicians with5 highest eigenvalue in the metric are highly interconnected. We conclude that the metrics captured the relations hipbetween the physicians in this community that coincide with the literature, indicating that we can find physicians who collaborate on patient care within and outside the hospital. In addition, physicians with largest eigenvalue indicate thatthey are reference to other physicians, and physicians who are connected to many others, suggest, that they influence their patients' decisions.

Information transfer dynamics in fixed-pathways networks.

Most complex technological networks are defined in such a way that their global properties are manifested at a dynamical level. An example of this is when internal dynamical processes are constrained to predefined pathways, without the possibility of alternate routes. For instance, large corporation software networks, where several flow processes take place, are typically routed along specific paths. In this work, we propose a model to describe the global characteristics of this kind of processes, where the dynamics depends on the state of the nodes, represented by two possibilities: responsive or blocked. We present numerical simulations that show rich global behavior with unexpected emerging properties. In particular, we show that two different regimes appear as a function of the total network load. Each regime is characterized by developing either a unimodal or a bimodal distribution for the density of responsive nodes, directly related to global efficiency. We provide a detailed explanation for the main characteristics of our results as well as an analysis of the implications for real technological systems.

Evolving learning rules and emergence of cooperation in spatial prisoner's dilemma.

In the evolutionary Prisoner's dilemma (PD) game, agents play with each other and update their strategies in every generation according to some microscopic dynamical rule. In its spatial version, agents do not play with every other but, instead, interact only with their neighbours, thus mimicking the existing of a social or contact network that defines who interacts with whom. In this work, we explore evolutionary, spatial PD systems consisting of two types of agents, each with a certain update (reproduction, learning) rule. We investigate two different scenarios: in the first case, update rules remain fixed for the entire evolution of the system; in the second case, agents update both strategy and update rule in every generation. We show that in a well-mixed population the evolutionary outcome is always full defection. We subsequently focus on two-strategy competition with nearest-neighbour interactions on the contact network and synchronised update of strategies. Our results show that, for an important range of the parameters of the game, the final state of the system is largely different from that arising from the usual setup of a single, fixed dynamical rule. Furthermore, the results are also very different if update rules are fixed or evolve with the strategies. In these respect, we have studied representative update rules, finding that some of them may become extinct while others prevail. We describe the new and rich variety of final outcomes that arise from this co-evolutionary dynamics. We include examples of other neighbourhoods and asynchronous updating that confirm the robustness of our conclusions. Our results pave the way to an evolutionary rationale for modelling social interactions through game theory with a preferred set of update rules.

Market impact and trading profile of hidden orders in stock markets.

We empirically study the market impact of trading orders. We are specifically interested in large trading orders that are executed incrementally, which we call hidden orders. These are statistically reconstructed based on information about market member codes using data from the Spanish Stock Market and the London Stock Exchange. We find that market impact is strongly concave, approximately increasing as the square root of order size. Furthermore, as a given order is executed, the impact grows in time according to a power law; after the order is finished, it reverts to a level of about 0.5-0.7 of its value at its peak. We observe that hidden orders are executed at a rate that more or less matches trading in the overall market, except for small deviations at the beginning and end of the order.

Diffusive anomalies in a long-range Hamiltonian system.

We scrutinize the anomalies in diffusion observed in an extended long-range system of classical rotors, the HMF model. Under suitable preparation, the system falls into long-lived quasi-stationary states for which superdiffusion of rotor phases has been reported. In the present work, we investigate diffusive motion by monitoring the evolution of full distributions of unfolded phases. After a transient, numerical histograms can be fitted by the q -Gaussian form P(x) proportional to {1+(q-1)[x/beta]2}(1/(1-q)) , with parameter q increasing with time before reaching a steady value q approximately 32 (squared Lorentzian). From the analysis of the second moment of numerical distributions, we also discuss the relaxation to equilibrium and show that diffusive motion in quasistationary trajectories depends strongly on system size.