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1.
Klin Med (Mosk) ; 88(4): 52-6, 2010.
Article in Russian | MEDLINE | ID: mdl-20919571

ABSTRACT

Lysates of erythrocytes and sera of 52 patients with osteoarthrosis (OA) and 30 healthy subjects were used used to determine adenosine deaminidase (ADA, AMP deaminase (AMPDA) and adenine deaminidase (AD). Their activities were unrelated to the age and sex of the patients. At admission, patients with OA showed enhanced activity of ADA in sera and reduced activity of AMPDA and AD in lysates compared with normal values. These changes depended on clinical features of OA and were especially pronounced in patients with poly-OA and synovitis. These data suggest participation of enzymes of the adenyl branch of purine metabolism in pathogenesis of OA. Treatment of hospitalized patients allowed to achieve positive dynamics of the above activities coupled to their improved clinical conditions even though enzymatic activity of erythrocyte lysates remained different from that in healthy subjects. It is concluded that enzymatic assays used in the study may be used as additional diagnostic methods for the assessment of synovitis and optimizatic of control over efficiency of OA therapy.


Subject(s)
AMP Deaminase/blood , Adenosine Deaminase/blood , Aminohydrolases/blood , Erythrocytes/enzymology , Osteoarthritis/enzymology , Female , Humans , Male , Middle Aged , Nucleic Acids/metabolism , Osteoarthritis/blood , Osteoarthritis/drug therapy , Purines/metabolism
2.
Ter Arkh ; 82(4): 48-52, 2010.
Article in Russian | MEDLINE | ID: mdl-20481216

ABSTRACT

AIM: To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS. MATERIALS AND METHODS: The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 +/- 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group. RESULTS: On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency. CONCLUSION: The findings suggest that there may be PM disturbances in the immunocompetent cells.


Subject(s)
Enzymes/blood , Purines/metabolism , Spondylitis, Ankylosing/diagnosis , Spondylitis, Ankylosing/enzymology , Adenosine Deaminase/blood , Adenosine Deaminase/metabolism , Adult , Enzymes/metabolism , Female , Guanine/metabolism , Guanine Deaminase/blood , Guanine Deaminase/metabolism , Humans , Male , Nucleoside Deaminases/blood , Nucleoside Deaminases/metabolism , Predictive Value of Tests , Purine-Nucleoside Phosphorylase/blood , Purine-Nucleoside Phosphorylase/metabolism , Spondylitis, Ankylosing/blood , Spondylitis, Ankylosing/metabolism , Xanthine Oxidase/blood , Xanthine Oxidase/metabolism
3.
Ter Arkh ; 75(5): 29-32, 2003.
Article in Russian | MEDLINE | ID: mdl-12847894

ABSTRACT

AIM: To evaluate effectiveness of a natural mineral bishofit in combined treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: The study included 71 RA patients with minimal activity of the pathological process and articular disorders of stage II. Bishofit was used in baths and compresses. 33 AR patients of group 1 took bishofit baths (14 procedures) and non-steroid anti-inflammatory drugs (NSAID), 27 RA patients of group 2 were treated with bishofit compresses (14 procesures) and NSAID, 11 patients of group 3 (controls) received NSAID alone. The effect of the treatment was assessed on the basis of clinical data, the length of the affected joint circumference, antitryptic blood activity, activity of malate dehydrogenase, lactate dehydrogenase isoenzymes, plasmin, plasminogen, ESR, sialic acids. RESULTS: Bishofit-treated patients showed earlier (by 5-6 days) and greater (by 25-35%) decrease of the pain, joint and inflammatory indices as well as duration of morning stiffness, length of the affected joint circumference and joint mobility, improvement of the tests' results. A response and an appreciable response to combined therapy with bishofit were achieved in 62.9-63.6% of cases vs 45.5% in the control group. Bishofit baths and compresses did not differ considerably by therapeutic efficacy.


Subject(s)
Arthritis, Rheumatoid/drug therapy , Magnesium Chloride/therapeutic use , Adult , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Arthritis, Rheumatoid/diagnosis , Arthritis, Rheumatoid/therapy , Bandages , Baths , Drug Combinations , Female , Humans , Magnesium Chloride/administration & dosage , Male , Minerals , Time Factors , Treatment Outcome
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