ABSTRACT
The excretion of compound M-11 and its metabolites with the urine and feces was studied in rats after intraperitoneal and oral administration in a dose of 25 mg/kg. Experiments showed that 1% metabolites were detected in excretions over 24 h irrespective of the route of administration, while the initial compound was not found even in trace amounts.
Subject(s)
Benzimidazoles/analysis , Benzimidazoles/metabolism , Benzimidazoles/pharmacokinetics , Feces/chemistry , Morpholines/analysis , Morpholines/metabolism , Morpholines/pharmacokinetics , Administration, Oral , Animals , Benzimidazoles/administration & dosage , Benzimidazoles/urine , Biotransformation , Chromatography, High Pressure Liquid , Injections, Intraperitoneal , Male , Molecular Structure , Morpholines/administration & dosage , Morpholines/urine , Rats , Tandem Mass Spectrometry , Time FactorsABSTRACT
Comparative analysis of pharmacokinetic parameters of afobazole and its main metabolite M-11 after single intraperitoneal injections of their solutions (25 mg/kg) to rats showed much more intense penetration of M-11 compared to afobazole into rat tissues and organs, judging from the area under the pharmacokinetic curve (AUC) and maximum concentrations (C(max)). The half-life periods (T(l/2e)l) of afobazole and M-11 were similar.
