PPARG Gene polymorphism and locomotor activity in humans.

The distribution of PPARG gene allele frequencies (Pro/Ala polymorphism) was studied in sportsmen specialized in speed and force athletics. A relationship between genotypes and human muscle transverse section area was evaluated. The PPARG Ala allele was significantly more incident in athletes than in controls, the incidence increasing with higher athletic qualification. A hypertrophic effect of PPARG Ala allele on muscle fibers was detected. Hence, the PPARG Pro12Ala polymorphism is associated with human motor activity.