ABSTRACT
The experiments on rats with a model acute pancreatitis showed that hepatoprotectors containing phospholipids (eplir and essentiale) improve the parameters of metabolism and the functions and histological characteristics of the pancreas and liver. Both drugs produced an antioxidant effect, decreased the activity of alpha-amylase, lipase, enzymes of hepatic origin in the blood, and reduced the content of creatinine, glucose, urea, bilirubin, and lipids. The therapeutic action of eplir was more pronounced than that of essentiale.
Subject(s)
Carotenoids/therapeutic use , Liver/drug effects , Pancreatitis/drug therapy , Phosphatidylcholines/therapeutic use , Phospholipids/therapeutic use , Acute Disease , Animals , Antioxidants/pharmacology , Antioxidants/therapeutic use , Carotenoids/pharmacology , Drug Combinations , Enzymes/blood , Liver/enzymology , Liver/metabolism , Pancreas/drug effects , Pancreas/enzymology , Pancreas/metabolism , Pancreatitis/enzymology , Pancreatitis/metabolism , Phosphatidylcholines/pharmacology , Phospholipids/pharmacology , RatsABSTRACT
Acute pancreatitis in rats caused by cooling of the pancreas with chloroethyl is characterized by the development of focal necrosis and activation of lipid peroxidation in the liver, activation of blood aminotransferase and acid and alkaline phosphatase, and increase in total and indirect bilirubin concentrations.
