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1.
Sensors (Basel) ; 22(21)2022 Nov 05.
Article in English | MEDLINE | ID: mdl-36366222

ABSTRACT

A low electromagnetic interference (EMI), precision temperature control system for sensitive piezoelectric sensors stabilization and their thermal characteristics research was proposed. Quartz crystal microbalance (QCM) was chosen as the device to be tested. Recently, QCMs found use in many fields of study such as biology, chemistry, and aerospace. They often operate in harsh environments and are exposed to many external factors including temperature fluctuations, to which QCMs are highly susceptible. Such disturbances can cause undesirable resonant frequency shifts resulting in measurement errors that are difficult to eliminate. The proposed solution enables measurements of QCMs thermal characteristics, effectiveness evaluation of temperature compensation methods, and testing of the frequency stability. As a part of the developed solution, two independent temperature regulators were used: first to maintain the QCM crystal at desired temperature, and second to keep the QCM oscillator circuit at fixed temperature. The single regulator consists of a thermoelectric module (TEC) used for both heating and cooling. Two considered TEC driving methods were compared in terms of EMI and their impact on the QCM signal quality. The proposed system was examined for its temperature stabilization capability showing high stability of 11 mKp-p for one hour and the setpoint accuracy of ±15 mK in the full temperature range.


Subject(s)
Biosensing Techniques , Quartz Crystal Microbalance Techniques , Temperature , Quartz Crystal Microbalance Techniques/methods , Cold Temperature , Biosensing Techniques/methods
2.
Sensors (Basel) ; 21(21)2021 Nov 03.
Article in English | MEDLINE | ID: mdl-34770625

ABSTRACT

This article proposes a new method for detecting slight refractive index changes under conditions of unknown polarization state. It is argued that an insignificant modification of the tilted fiber Bragg grating (TFBG) structure and selecting the appropriate spectral region allows us to accurately track changes in the refractive index. It has also been proven that the method can be easily made insensitive to temperature and that the sensitivity to changes in the polarization plane of the input light can be significantly reduced, which is crucial in later practical applications. Analytes in the form of an aqueous glucose solution were used to calibrate the sensor. The proposed method, based on perpendicular tilted fiber Bragg grating (P-TFBG), has a wide range of universality because its development and slight modification will enable the detection of glucose, pathogens, and viruses.


Subject(s)
Refraction, Ocular , Refractometry
3.
Sensors (Basel) ; 21(8)2021 Apr 20.
Article in English | MEDLINE | ID: mdl-33923949

ABSTRACT

Thermionic emission sources are key components of electron impact gas ion sources used in measuring instruments, such as mass spectrometers, ionization gauges, and apparatus for ionization cross-section measurements. The repeatability of the measurements taken with such instruments depends on the stability of the ion current, which is a function, among other things, of the electron beam current and electron accelerating voltage. In this paper, a laboratory thermionic electron beam current and accelerating voltage controller is presented, based on digital algorithm implementation. The average value of the percentage standard deviation of the emission current is 0.021%, and the maximum electron accelerating voltage change versus the emission current is smaller than 0.011% in the full operating range of the emission current. Its application as a trap current or emission current-regulated ion source power supply could be useful in many measuring instruments, such as in microelectromechanical system (MEMS) mass spectrometers as universal gas sensors, where a stable emission current and electron energy are needed.

4.
IEEE Trans Biomed Eng ; 68(3): 739-746, 2021 03.
Article in English | MEDLINE | ID: mdl-32746039

ABSTRACT

OBJECTIVE: Although spirometry is the most common pulmonary function test, there is no method to quantitatively infer about airway resistance or other properties from the flow-volume curves. Recently, an identifiable inverse model for forced expiration was proposed, as well as the idea to deduce changes in airway resistances and compliances from spirometric curve evolution. The aim of this work was to combine the above advances in a method for assessing the airway response to bronchial tests from a spirometric curve shift. METHODS: The approach is based on the differential measurement of the degree, site of maximal effect and width of changes, further recalculated into relative changes in the distribution of airway resistances (δRg) and compliances (δCg) along the bronchial tree. To this end, appropriate models were identified using the pre- and post-test spirometry data. The accuracy was validated using sets of data simulated by the anatomy and physiology based models. Finally, the method was used to analyze the bronchodilation tests of three asthmatic subjects. RESULTS: The expected errors in assessing the degree, site and width of changes in the zone of conducting airways were 6.3%, 2.4 generations and 22%, respectively, and for δRg and δCg were 5-10% and 13-16%, respectively. The analyses of clinical data indicated a significant reduction in resistances and an increase in compliances of airway generations 8-12, consistent with clinical knowledge. CONCLUSION: An unprecedented method to plausibly transforming the spirometry data into the site and degree of changes in airway properties has been proposed. SIGNIFICANCE: The method can be used to deduce about the effects of bronchial tests, as well as to monitor changes in the airways between visits or to investigate how inhaled pharmaceuticals affect the bronchi.


Subject(s)
Asthma , Bronchi , Airway Resistance , Humans , Lung , Spirometry
5.
Sensors (Basel) ; 20(9)2020 May 06.
Article in English | MEDLINE | ID: mdl-32384715

ABSTRACT

This article presents the use of a sensor with fiber Bragg grating along with an interrogation system used for monitoring the overhead lines' wire elongation. The possible interrogation methods based on adjusted filters were considered. In the experimental part, three types of fiber Bragg grating pairs, characterized by a small shift in spectra in pairs and gratings with exact matching, were examined. The study showed that, by choosing the appropriate mechanical parameters of the elongation transformer with the optical parameters of the sensor and dedicated filter, the optomechanical system can be adjusted to the required range of overhead line wire sag observation. The range of sag depends on the distance between the poles, the wire type, and its real length in the span, which effectively determines the sag.

6.
Comput Methods Programs Biomed ; 173: 139-145, 2019 May.
Article in English | MEDLINE | ID: mdl-31046988

ABSTRACT

BACKGROUND AND OBJECTIVES: The most widespread chronic pulmonary disorders are associated with heterogeneous changes in the lung periphery and spirometry is the most commonly used test to monitor these diseases. So far only a few attempts have been undertaken to investigate the effects of lung inhomogeneity on spirometry results. The aim of this work was to evaluate whether the spirometric curve and indexes are sensitive to parallel peripheral inhomogeneities, and if the level of heterogeneity can be deduced from this test. METHODS: To this end, an enhanced computational model for forced expiration, taking into account a heterogeneous structure and properties of the respiratory system, was used. Two main phenomena were mimicked: small airways narrowing and the loss of tissue elastic recoil. Numerical simulations were performed with the model having 76 separate peripheral compartments. For a given degree of mean change, three heterogeneity levels were investigated and compared to the effects of homogeneous alterations. RESULTS: All spirometric curves representing different patterns of inhomogeneous constriction, computed for each of the investigated cases, almost coincided with the curve originating from homogeneous changes, regardless of the heterogeneity level. Also the differences between the spirometric indexes obtained for heterogeneous and homogeneous alterations were negligible in comparison to their values. CONCLUSION: The main finding is that the spirometry results are insensitive to the level of heterogeneity in the lung periphery and that it is practically impossible to distinguish between the homogeneous or heterogeneous nature of pathological processes occurring in this lung region.


Subject(s)
Asthma/diagnosis , Lung/pathology , Pulmonary Disease, Chronic Obstructive/diagnosis , Spirometry , Adult , Aged , Algorithms , Computer Simulation , Elasticity , Female , Forced Expiratory Volume , Humans , Lung/diagnostic imaging , Male , Muscles/pathology , Predictive Value of Tests , Respiration
7.
Sensors (Basel) ; 19(9)2019 Apr 26.
Article in English | MEDLINE | ID: mdl-31027388

ABSTRACT

Tilted fiber Bragg grating (TFBG) is a very popular fiber optic element that is used as a sensor for various physical quantities. The calculation of the refractive index of a substance surrounding the TFBG is based on its spectrum demodulation, which consists of determining a certain parameter that is correlated with the sought quantity. The most commonly used parameter is the area created by the maxima and minima of the cladding mode resonances. In this article, we propose a new group of methods, which are based on calculating the parameters related to the spectrum differences between the local average values in the range of occurrence of the cladding modes. The basic parameter used in this group of methods is the mean absolute deviation from the local mean, which is characterized by the best linearity among the considered group of methods. The calculated parameters, in their cumulative form, can also be used to determine the cut-off wavelength, which can also indirectly indicate the refractive index value. The proposed approaches were compared, in terms of measurement resolution, to the most commonly used methods, such as the cladding modes' envelope area and the spectral contour lengths.

8.
Opt Lett ; 43(18): 4445-4448, 2018 Sep 15.
Article in English | MEDLINE | ID: mdl-30211886

ABSTRACT

In this Letter, it has been shown that the twisting of TFBGs (tilted fiber Bragg gratings) decreases their sensitivity to the polarization of the input light. It has been proved by a theoretical simulation study that twisting the TFBG by 180° eliminates the sensitivity of the grating to input light polarization changes. We have experimentally proved that our structure produced has an 18 times lower coefficient of variation of transmission for polarization changes than the untwisted TFBG. This Letter also presents a new method for manufacturing the twisted tilted fiber Bragg grating (TTFBG). We have demonstrated the possibility of writing the TTFBG structure twisted by 90° on a fiber with a length of 10 mm. The structure has been further twisted in the other direction by 90°, which is consistent with a structure twisted by 180°. The properties of both structures were determined. Due to the fiber's strength, the TTFBG twisted by 180° has to be 2 cm long. An advantage of the proposed method of producing the TTFBG is that there is a twist of the structure itself after fabrication. This creates new possibilities of using the structure in many applications. This type of grating can be used to reduce the sensitivity to polarization in various sensing applications, in particular, to measure the refractive index. In addition, a 180° twisted TTFBG has properties of direction discrimination in twist sensing applications.

9.
Comput Biol Med ; 81: 93-105, 2017 02 01.
Article in English | MEDLINE | ID: mdl-28027461

ABSTRACT

Since computed tomography (CT) was developed over 35 years ago, new mathematical ideas and computational algorithms have been continuingly elaborated to improve the quality of reconstructed images. In recent years, a considerable effort can be noticed to apply the sparse solution of underdetermined system theory to the reconstruction of CT images from undersampled data. Its significance stems from the possibility of obtaining good quality CT images from low dose projections. Among diverse approaches, total variation (TV) minimizing 2D gradients of an image, seems to be the most popular method. In this paper, a new method for CT image reconstruction via sparse gradients estimation (SGE), is proposed. It consists in estimating 1D gradients specified in four directions using the iterative reweighting algorithm. To investigate its properties and to compare it with TV and other related methods, numerical simulations were performed according to the Monte Carlo scheme, using the Shepp-Logan and more realistic brain phantoms scanned at 9-60 directions in the range from 0 to 179°, with measurement data disturbed by additive Gaussians noise characterized by the relative level of 0.1%, 0.2%, 0.5%, 1%, 2% and 5%. The accuracy of image reconstruction was assessed in terms of the relative root-mean-square (RMS) error. The results show that the proposed SGE algorithm has returned more accurate images than TV for the cases fulfilling the sparsity conditions. Particularly, it preserves sharp edges of regions representing different tissues or organs and yields images of much better quality reconstructed from a small number of projections disturbed by relatively low measurement noise.


Subject(s)
Algorithms , Brain/diagnostic imaging , Machine Learning , Pattern Recognition, Automated/methods , Radiographic Image Interpretation, Computer-Assisted/methods , Tomography, X-Ray Computed/methods , Humans , Phantoms, Imaging , Radiographic Image Enhancement/methods , Reproducibility of Results , Sensitivity and Specificity , Tomography, X-Ray Computed/instrumentation
10.
J Opt Soc Am A Opt Image Sci Vis ; 33(4): 667-76, 2016 04 01.
Article in English | MEDLINE | ID: mdl-27140778

ABSTRACT

When a plane electromagnetic wave is scattered by an optically transparent object, whose size is much larger than the wavelength, a series of bright and dark fringes forms the primary rainbow, which is one of the most splendid phenomena in nature. In this work, an optical technique is discussed for simultaneous measurement of the diameter and refractive index of an axisymmetric and dielectric fiber by studying some rainbow features. This noncontact optical technique uses a beam of light exhibiting low temporal coherence, which enabled us to reduce the detrimental sensitivity of the rainbow features to variations of the fiber properties, thus allowing for high-precision estimates. Approximate mathematical formulas for the diameter and refractive index measurements were derived from the lowest-order complex angular momentum correction to Airy theory of rainbow. Furthermore, sensitivity of the measurement data to small deformation of the fiber's cross section into an ellipse was discussed. Preliminary empirical results provide a qualitative verification.

11.
Opt Express ; 24(26): 29922-29929, 2016 Dec 26.
Article in English | MEDLINE | ID: mdl-28059376

ABSTRACT

In this paper, we present a method for the simultaneous measurement of rotation and displacement or rotation and bending using single tilted fiber Bragg grating (TFBG). The insensitivity of the proposed system to temperature changes and the stretching direction of the fiber section in the sensing structure have been demonstrated. The experimentally determined sensitivities for rotation, displacement and bending are as follows: -0.0018 1/deg., 0.0054 nm/mm, and -0.055 1/mm over the measurement ranges of approximately 25-80 degrees, 34-74 mm, and 26.4-20 mm, respectively. The presented measurement system is versatile due to the ability to tune the measurement range by changing the fiber-loop radius.

12.
Comput Methods Programs Biomed ; 122(3): 330-40, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26363677

ABSTRACT

Increased heterogeneity of the lung disturbs pulmonary gas exchange. During bronchoconstriction, inflammation of lung parenchyma or acute respiratory distress syndrome, inhomogeneous lung ventilation can become bimodal and increase the risk of ventilator-induced lung injury during mechanical ventilation. A simple index sensitive to ventilation heterogeneity would be very useful in clinical practice. In the case of bimodal ventilation, the index (H) can be defined as the ratio between the longer and shorter time constant characterising regions of contrary mechanical properties. These time constants can be derived from the Otis model fitted to input impedance (Zin) measured using forced oscillations. In this paper we systematically investigated properties of the aforementioned approach. The research included both numerical simulations and real experiments with a dual-lung simulator. Firstly, a computational model mimicking the physical simulator was derived and then used as a forward model to generate synthetic flow and pressure signals. These data were used to calculate the input impedance and then the Otis inverse model was fitted to Zin by means of the Levenberg-Marquardt (LM) algorithm. Finally, the obtained estimates of model parameters were used to compute H. The analysis of the above procedure was performed in the frame of Monte Carlo simulations. For each selected value of H, forward simulations with randomly chosen lung parameters were repeated 1000 times. Resulting signals were superimposed by additive Gaussian noise. The estimated values of H properly indicated the increasing level of simulated inhomogeneity, however with underestimation and variation increasing with H. The main factor responsible for the growing estimation bias was the fixed starting vector required by the LM algorithm. Introduction of a correction formula perfectly reduced this systematic error. The experimental results with the dual-lung simulator confirmed potential of the proposed procedure to properly deduce the lung heterogeneity level. We conclude that the heterogeneity index H can be used to assess bimodal ventilation imbalances in cases when this phenomenon dominates lung properties, however future analyses, including the impact of lung tissue viscoelasticity and distributed airway or tissue inhomogeneity on H estimates, as well as studies in the time domain, are advisable.


Subject(s)
High-Frequency Ventilation , Models, Anatomic , Ventilator-Induced Lung Injury/prevention & control , Bronchoconstriction/physiology , Humans , Lung/physiopathology , Monte Carlo Method , Pneumonia/physiopathology , Pulmonary Gas Exchange/physiology , Respiration, Artificial , Respiratory Distress Syndrome/physiopathology
13.
Appl Opt ; 53(30): 7103-11, 2014 Oct 20.
Article in English | MEDLINE | ID: mdl-25402800

ABSTRACT

The objective of this paper is to discuss the possibility of noninvasive optical characterization of a transparent (glass) fiber by means of low-coherent light scattering. It will be shown that, by adjusting the temporal coherence of incident light, it is possible to select these specific orders of scattering, which are related to diffraction. Discussion will be devoted to the direct scattering and the inverse problem, where an inference about the diameter of a multilayered and transparent fiber is accomplished.

14.
Appl Opt ; 53(19): 4239-47, 2014 Jul 01.
Article in English | MEDLINE | ID: mdl-25089986

ABSTRACT

The aim of this paper is to discuss the possibility of a noninvasive, optical characterization of a transparent (glass) fiber on the basis of scattered light in the vicinity of a primary rainbow. Computational studies show that with the use of a spectrally adjusted incident beam of light, it is possible to form a rainbow with no strong nonlinearities typical for coherent light and that may be interpreted in terms of Airy's theory of rainbow. An inverse analysis is applied to obtain the fiber diameter with the help of a straightforward mathematical formula based on the Airy integral, corrected by comparison with the solution according to the complex angular momentum method.

15.
Appl Opt ; 51(11): 1715-23, 2012 Apr 10.
Article in English | MEDLINE | ID: mdl-22505162

ABSTRACT

We present further results of the simulation research on the constrained regularized least squares (CRLS) solution of the ill-conditioned inverse problem in spectral extinction (turbidimetric) measurements, which we originally presented in this journal [Appl. Opt. 49, 4591 (2010)]. The inverse problem consists of determining the particle size distribution (PSD) function of a particulate system on the basis of a measured extinction coefficient as a function of wavelength. In our previous paper, it was shown that under assumed conditions the problem can be formulated in terms of the discretized Fredholm integral equation of the first kind. The CRLS method incorporates two constraints, which the PSD sought will satisfy: nonnegativity of the PSD values and normalization of the PSD to unity when integrated over the whole range of particle size, into the regularized least squares (RLS) method. This leads to the quadratic programming problem, which is solved by means of the active set algorithm within the research. The simulation research that is the subject of the present paper is a continuation and extension of the research described in our previous paper. In the present research, the performance of the CRLS method variants is compared not only to the corresponding RLS method variants but also to other regularization techniques: the truncated generalized singular value decomposition and the filtered generalized singular value decomposition, as well as nonlinear iterative algorithms: The Twomey algorithm and the Twomey-Markowski algorithm. Moreover, two methods of selecting the optimum value of the regularization parameter are considered: The L-curve method and the generalized cross validation method. The results of our simulation research provide even stronger proof that the CRLS method performs considerably better with reconstruction of PSD than other inversing methods, in terms of better fidelity and smaller uncertainty.

16.
Appl Opt ; 50(30): 5759-69, 2011 Oct 20.
Article in English | MEDLINE | ID: mdl-22015402

ABSTRACT

We report experimental investigations on the influence of various optical effects on the far-field scattering pattern produced by a cloud of optical bubbles near the critical scattering angle. Among the effects considered, there is the change of the relative refractive index of the bubbles (gas bubbles or some liquid-liquid droplets), the influence of intensity gradients induced by the laser beam intensity profile and by the spatial filtering of the collection optics, the coherent and multiple scattering effects occurring for densely packed bubbles, and the tilt angle of spheroidal optical bubbles. The results obtained herein are thought to be fundamental for the development of future works to model these effects and for the extension of the range of applicability of an inverse technique (referenced herein as the critical angle refractometry and sizing technique), which is used to determine the size distribution and composition of bubbly flows.

17.
Comput Methods Programs Biomed ; 101(2): 115-25, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21146246

ABSTRACT

Respiratory input impedance contains information about the state of pulmonary mechanics in the frequency domain. In this paper the possibility of respiratory impedance measurement by interrupter technique as well as the accuracy of this approach are assessed. Transient states of flow and pressure recorded during expiratory flow interruption are simulated with a complex, linear model for the respiratory system and then used to calculate the impedance, including three states of respiratory mechanics and the influence of the measurement noise. The results of computations are compared to the known, theoretical impedance of the model. At 1 kHz sampling rate, the optimal time window lays between 100 and 200 ms and is centred around the pressure jump caused by the flow interruption. The proposed algorithm yields satisfactory accuracy in the range from 10 to 400 Hz, particularly to 150 Hz. Depending on the simulated respiratory system state, the error of calculated impedance (relative Euclidean distance between the vectors of computed and theoretical values), for the window of 190 ms, varies between 5.0% and 7.1%.


Subject(s)
Respiratory Function Tests , Humans , Reproducibility of Results
18.
Article in English | MEDLINE | ID: mdl-21096360

ABSTRACT

The paper offers an enhancement of the classical interrupter technique algorithm dedicated to respiratory mechanics measurements. Idea consists in exploitation of information contained in postocclusional transient states during indirect measurement of parameter characteristics by model identification. It needs the adequacy of an inverse analogue to general behavior of the real system and a reliable algorithm of parameter estimation. The second one was a subject of reported works, which finally showed the potential of the approach to separation of airway and tissue response in a case of short-term excitation by interrupter valve operation. Investigations were conducted in a regime of forward-inverse computer experiment.


Subject(s)
Algorithms , Diagnosis, Computer-Assisted/methods , Models, Biological , Pattern Recognition, Automated/methods , Respiratory Function Tests/methods , Respiratory Mechanics/physiology , Computer Simulation , Humans , Reproducibility of Results , Sensitivity and Specificity
19.
Article in English | MEDLINE | ID: mdl-21095897

ABSTRACT

The paper presents methodology of a complex model reduction to its simpler version - an identifiable inverse model. Its main tool is a numerical procedure of sensitivity analysis (structural and parametric) applied to the forward linear equivalent designed for the conditions of interrupter experiment. Final result - the reduced analog for the interrupter technique is especially worth of notice as it fills a major gap in occlusional measurements, which typically use simple, one- or two-element physical representations. Proposed electrical reduced circuit, being structural combination of resistive, inertial and elastic properties, can be perceived as a candidate for reliable reconstruction and quantification (in the time and frequency domain) of dynamical behavior of the respiratory system in response to a quasi-step excitation by valve closure.


Subject(s)
Airway Resistance , Models, Biological , Respiratory Function Tests/methods , Respiratory Mechanics , Respiratory System/physiopathology , Respiratory Tract Diseases/diagnosis , Respiratory Tract Diseases/physiopathology , Computer Simulation , Diagnosis, Computer-Assisted/methods , Humans , Linear Models , Reproducibility of Results , Sensitivity and Specificity
20.
Appl Opt ; 49(24): 4591-603, 2010 Aug 20.
Article in English | MEDLINE | ID: mdl-20733631

ABSTRACT

We present results of simulation research on the constrained regularized least-squares (RLS) solution of the ill-conditioned inverse problem in turbidimetric measurements. The problem is formulated in terms of the discretized Fredholm integral equation of the first kind. The inverse problem in turbidimetric measurements consists in determining particle size distribution (PSD) function of particulate system on the basis of turbidimetric measurements. The desired PSD should satisfy two constraints: nonnegativity of PSD values and normalization of PSD to unity when integrated over the whole range of particle size. Incorporating the constraints into the RLS method leads to the constrained regularized least-squares (CRLS) method, which is realized by means of an active set algorithm of quadratic programming. Results of simulation research prove that the CRLS method performs considerably better with reconstruction of PSD than the RLS method in terms of better fidelity and smaller uncertainty.

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