ABSTRACT
INTRODUCTION: Hand-foot syndrome (HFS) is a limiting toxicity of capecitabine, which is not life-threatening but could compromise capecitabine efficacy. MATERIALS AND METHODS: This phase II, multicenter, non-controlled study assessed the safety, particularly grade three HFS incidence, and efficacy of four capecitabine-based chemotherapy regimens [cisplatin/capecitabine (CX), epirubicin/cisplatin/capecitabine (ECX), epirubicin/oxaliplatin/capecitabine (EOX) and docetaxel/cisplatin/capecitabine (DCX)] as first-line treatment for advanced and/or metastatic gastric cancer. RESULTS: One hundred and eight patients were assigned to one of the four treatment groups, according to investigator's criteria, and grouped together for both safety and efficacy primary analyses. HFS was reported in 31 patients (19.6%) and its first presentation occurred at a median of 72 days (range 19-209 days). Grade 3 HFS developed in 6.3, 5.2, 3.7 and 2.4%, of patients receiving ECX, DCX, EOX or CX chemotherapy regimen, respectively. Capecitabine dose reduction/discontinuation due to HFS was required in 5.7% of patients (9/158). The most common (> 10%) grade 3-4 treatment-related AEs were neutropenia (15.2%), asthenia (12.0%) and diarrhoea (11.4%). CONCLUSIONS: A moderate incidence of HFS was reported in patients treated with capecitabine, which generally presented late and required dose reduction in < 1/3 of patients. The results suggest that capecitabine may be useful in combination with standard fluorouracil-based regimens in patients with advanced and/or metastatic gastric cancer with favourable safety profile (AU)
Subject(s)
Humans , Male , Female , Toxicity/adverse effects , Toxicity/classification , Toxicity/methods , Toxicity/analysis , Toxicity/statistics & numerical dataABSTRACT
The electrochemiluminescence (ECL) of a luminol derivate (ABEI) generated both by a carbon electrode and a polypyrrole-coated carbon electrode was examined. It was found that the polypyrrole film (ppy) did not inhibit the ECL. After that, ABEI anchored on a single stranded DNA target (ODNt) has been used for the ECL detection of the hybridization between a complementary single stranded DNA probe (ODNp) covalently linked to a polypyrrole support and the ODNt. The ECL detection has been performed using a DNA sensor having a low surface concentration of ODNp probes, constituted of a polypyrrole copolymer electrosynthesized from a pyrrole-ODNp/pyrrole monomer ratio of 1/20,000.
Subject(s)
Luminol/analogs & derivatives , Nucleic Acid Hybridization/methods , Oligonucleotide Array Sequence Analysis/methods , Electrochemistry/methods , Electrodes , Luminescent Measurements/methods , Luminol/chemistry , Membranes, Artificial , Polymers , PyrrolesABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Lower Extremity/physiopathology , Muscle Fatigue , Pain/complications , Forearm/pathology , Fasciitis/complications , Fasciitis/physiopathology , Adrenal Cortex Hormones/therapeutic use , Biopsy , Methotrexate/therapeutic use , Hypersensitivity/complications , Hypersensitivity/diagnosis , Hypersensitivity/drug therapyABSTRACT
El reflejo estapedial se viene utilizando, entre otras patologías, para el estudio de la otoesclerosis. En este trabajo retrospectivo hemos reunido 188 historias de pacientes con otoesclerosis confirmada quirúrgicamente y familiares directos de los mismos. Se ha realizado un estudio descriptivo de los estudios audiométricos, timpanometrías y reflejos estapediales ipsilaterales en relación con la fase evolutiva de la otoesclerosis. La hipoacusia de transmisión se ha presentado en el 54%, la hipoacusia mixta en el 29% y la hipoacusia neurosensorial en el 8%. Los reflejos estapediales ON-OFF se han presentado en el 18%, los reflejos invertidos en el 46% y la ausencia de reflejos en el 27%. En las cuatro figuras se recogen los trazados originales de los diferentes tipos de reflejos a lo largo de la evolución de la otoesclerosis: reflejos normales; ON-OFF tipos a, b y c; invertidos a y b; y ausentes. Se correlaciona la fase evolutiva clínica con las audiometrías y los estudios impedanciométricos. Mediante Chi-cuadrado (p<0,001) se ha obtenido significancia estadística en relación con la mayor utilidad de los reflejos estapediales. También se propone la realización del reflejo estapedial provocado en pacientes con otoesclerosis subclínica para desenmascarar la enfermedad. Se concluye que el conocimiento de la morfología evolutiva de los reflejos estapediales en la otoesclerosis ayuda a la capacidad diagnóstica (AU)
Stapedial reflex is used, amongst other pathologies, for the study of otosclerosis. In this retrospective study we have collected 188 cases of patients with otosclerosis whose diagnosis has been confirmed surgically and their first line relatives. We have performed a descriptive analysis of audiometric tests, tympanometries and ipsilateral stapedial reflexes in relation with the evolutive phase of the disease. Transmission hypoacusis has been seen in 54%, mixed hypoacusis in 29% and sensorineural hypoacusis 8% of cases. On and OFF stapedial reflexes have been seen in 18%, inverted reflexes in 46% and absent reflexes in 27% of cases. The original drawings of the different types of reflexes during the evolution of otosclerosis can be seen in the four figures shown in the study: normal reflexes; ON and OFF a, b and c types; inverted a and b; and absent reflexes. The clinical evolutive phase and the audiometric and impedance tests have been correlated. Through Chi-square (p < 0.001), we have obtained a statistical significance in relation to the use of stapedial reflexes. Also it has been suggested the use of provoked stapedial reflexes in patients with sub clinical otosclerosis in order to diagnose the disease. We conclude that the knowledge of the evolutive morphology os stapedial reflexes in otosclerosis helps diagnostic capacity (AU)
