Subject(s)
Glucocorticoids/therapeutic use , Lymphangioma/drug therapy , Orbital Neoplasms/drug therapy , Prednisone/therapeutic use , Administration, Oral , Biopsy , Child , Diagnosis, Differential , Diplopia/etiology , Exophthalmos/etiology , Female , Glucocorticoids/administration & dosage , Humans , Lymphangioma/complications , Lymphangioma/diagnosis , Magnetic Resonance Imaging , Orbital Neoplasms/complications , Orbital Neoplasms/diagnosis , Prednisone/administration & dosage , Tomography, X-Ray Computed , Visual AcuityABSTRACT
Anterior uveitis and elevated intraocular pressure (IOP) occurred after radial keratotomy that was complicated by microperforation and penetration of antibiotic ophthalmic ointment into the anterior chamber. Anterior uveitis and IOP elevation were observed during the early postoperative follow-up and 41 and 61 months after surgery. All 3 attacks responded well to topical anti-inflammatory and antiglaucoma treatment. The probable causes of the uveitis and glaucoma in this case are discussed.
Subject(s)
Anterior Chamber/drug effects , Anti-Bacterial Agents/adverse effects , Corneal Injuries , Glaucoma/chemically induced , Intraoperative Complications , Keratotomy, Radial/adverse effects , Tobramycin/adverse effects , Uveitis, Anterior/chemically induced , Administration, Topical , Adult , Humans , Intraocular Pressure/drug effects , Male , Ointments/adverse effects , Recurrence , Rupture , Visual AcuityABSTRACT
PURPOSE: To evaluate the efficacy of topical zinc desferrioxamine in acute corneal alkali injury in rabbits. METHODS: Twenty rabbits were anesthetized and a standardized alkali burn (1N NaOH) was performed in the center of the cornea (7.5-mm diameter). The animals were randomly divided into two groups and treated (double-masked) with topical zinc desferrioxamine, 220 microM, (group 1) or its vehicle (group 2). Drops were applied 7 times/day for 28 days. Topical gentamicin, 0.3%, was instilled twice a day. Animals were evaluated twice a week. At each examination (using the slit-lamp), the depth of corneal ulcer was graded as follows: 0, no ulcer; 1, tissue loss less than one third of corneal thickness; 2, one third to two thirds tissue loss; 3, more than two thirds tissue loss; 4, descemetocele; or 5, perforation. Ulceration area, vascularization, and epithelial defects also were measured. RESULTS: During the study period, the grading of mean corneal ulcerations in group 1 ranged from 0.2 to 1.00, whereas in group 2, it ranged from 1.4 to 2.7. The mean grade and area of ulceration in group 2 were greater than those in group 1 (p < 0.05). CONCLUSION: Topical zinc desferrioxamine may be an adjunctive treatment in protecting the cornea against induced alkali injury.
