ABSTRACT
BACKGROUND: Extremely low birth weight (ELBW) infants are at increased risk for invasive candidiasis and associated morbidity and mortality. The use of fluconazole prophylaxis in this population has raised a benefit versus risk concern among clinicians. OBJECTIVES: To evaluate the effectiveness and safety of fluconazole prophylaxis in ELBW infants. STUDY DESIGN: ELBW infants (BWSubject(s)
Antibiotic Prophylaxis
, Antifungal Agents/adverse effects
, Candidiasis/epidemiology
, Candidiasis/prevention & control
, Cholestasis/chemically induced
, Fluconazole/adverse effects
, Infant, Very Low Birth Weight
, Alkaline Phosphatase/blood
, Antifungal Agents/administration & dosage
, Antifungal Agents/therapeutic use
, Bilirubin/blood
, Candidiasis/etiology
, Case-Control Studies
, Cholestasis/blood
, Female
, Fluconazole/administration & dosage
, Fluconazole/therapeutic use
, Humans
, Infant, Newborn
, Infant, Premature, Diseases/epidemiology
, Infant, Premature, Diseases/etiology
, Infant, Premature, Diseases/prevention & control
, Male
, New Jersey/epidemiology
, Retrospective Studies
