1.
Proc Soc Exp Biol Med
; 196(3): 301-6, 1991 Mar.
Article
in English
| MEDLINE
| ID: mdl-1998007
ABSTRACT
Progesterone (P), a major hormone of pregnancy, was selected for study under the conditions of an intact utero-placental-fetal unit. A preparation of the canine gravid uterus, near term, is described and shown to permit observation of the metabolic relationships of the steroid hormone P between maternal and fetal organisms. [1,2-3H] P or [7 alpha-3H]P was injected into pups, while [4-14C]P was injected into the uterine circulation. Perfusion was continued for 1 hr with excellent survival of the pups. Identified metabolites in the fetal and maternal tissues suggest a metabolic pool that is shared throughout the unit.
Subject(s)
Fetus/metabolism , Placenta/metabolism , Progesterone/metabolism , Animals , Brain/metabolism , Chromatography, Gas , Chromatography, High Pressure Liquid , Dogs , Female , Intestinal Mucosa/metabolism , Liver/metabolism , Lung/metabolism , Maternal-Fetal Exchange , Pregnancy , Uterus/metabolism
2.
Proc Soc Exp Biol Med
; 143(4): 1197-200, 1973 Sep.
Article
in English
| MEDLINE
| ID: mdl-4355244
3.
Proc Soc Exp Biol Med
; 131(4): 1389-92, 1969 Sep.
Article
in English
| MEDLINE
| ID: mdl-4309477
4.
Endocrinology
; 85(2): 365-7, 1969 Aug.
Article
in English
| MEDLINE
| ID: mdl-4306607
Subject(s)
Adrenal Glands/metabolism , Animals, Newborn/physiology , Dexamethasone/pharmacology , Hypothalamo-Hypophyseal System/physiology , Pituitary-Adrenal System , Adrenocorticotropic Hormone/pharmacology , Animals , Depression, Chemical , Dogs , Feedback , Female , Hydrocortisone/blood , Hydrocortisone/metabolism , Hypothalamo-Hypophyseal System/drug effects , Male , Pituitary-Adrenal System/drug effects
5.
Proc Soc Exp Biol Med
; 130(2): 574-6, 1969 Feb.
Article
in English
| MEDLINE
| ID: mdl-5250064
6.
Circulation
; 36(4): 539-43, 1967 Oct.
Article
in English
| MEDLINE
| ID: mdl-6041867
