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1.
Ann Epidemiol ; 8(1): 46-51, 1998 Jan.
Article in English | MEDLINE | ID: mdl-9465993

ABSTRACT

PURPOSE: Cancers recorded in the Tumor Registry at the American University of Beirut Medical Center (AUBMC), the largest tertiary care center, in Lebanon were reviewed. METHODS: Results were compared with those from the same center 30 years ago and current data from western Asia. RESULTS: Between 1983 and 1994, 9364 cases were recorded, averaging 780 cases per year, representing more than one-third of the national case-load. Cases were almost equally distributed between males and females. Average age of females was significantly younger (48.7 years) than that of males (52.2 years). Among males, the five most frequently reported cancers were of the lung, bladder, larynx, lymphoma, and leukemia. Among females, the four most frequently reported cancers were of the breast, cervix uteri, lymphoma, and brain, with leukemia and corpus uteri ranking equally as fifth. Over the past 30 years, the frequency of colorectal cancer decreased and that of lung cancer increased in both sexes. Oral cancer decreased dramatically among males. Digestive system cancers in this series were less frequent than in cumulative data from western Asia area. CONCLUSIONS: Cancer dynamics changed little since the 1950s, except regard to cancers related to smoking and diet. Diet differences may explain the lower frequencies of digestive cancers in Lebanon as compared with elsewhere in western Asia. The potential impact of cancer prevention and early detection on highly prevalent cancer types such as lung, larynx, breast, and cervix was highlighted.


Subject(s)
Neoplasms/epidemiology , Registries , Academic Medical Centers , Adolescent , Age Distribution , Child , Databases, Factual , Diet/adverse effects , Female , Humans , Incidence , Lebanon/epidemiology , Male , Middle Aged , Neoplasms/etiology , Population Surveillance , Sex Distribution , Smoking/adverse effects
2.
J Med Liban ; 44(1): 41-3, 1996.
Article in English | MEDLINE | ID: mdl-8885560

ABSTRACT

A 50-year-old woman sought a rheumatological consultation for anterior chest pain of three weeks duration. The diagnosis of superficial phlebitis of the anterior chest wall (Mondor's disease) was made. This was confirmed thereafter by the pathological report. She was treated with a non-steroidal anti-inflammatory drug Oxyphenylbutazone (Tanderil) and made a prompt recovery.


Subject(s)
Chest Pain/etiology , Phlebitis/complications , Thoracic Diseases/complications , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Chest Pain/drug therapy , Female , Humans , Middle Aged , Oxyphenbutazone/therapeutic use , Phlebitis/drug therapy , Phlebitis/pathology , Thoracic Diseases/drug therapy , Thoracic Diseases/pathology , Thorax/blood supply
3.
Gynecol Oncol ; 52(1): 91-3, 1994 Jan.
Article in English | MEDLINE | ID: mdl-8307508

ABSTRACT

The present report describes a 27-year-old woman diagnosed with Ann Arbor stage IE primary malignant lymphoma of the cervix. Radiation therapy was instituted as conventionally advocated at this early stage of the disease. Despite adequate local tumor response, central nervous system metastasis occurred a few months later. She succumbed to her condition 7 months after initial diagnosis. As occult distant foci may not be amenable to detection by available imaging techniques at the time of initial work-up, combination chemotherapy alone or in conjunction with radiation therapy may be the most appropriate first line of therapy in patients with stage IE primary malignant lymphoma of the cervix.


Subject(s)
Brain Neoplasms/secondary , Lymphoma/radiotherapy , Uterine Cervical Neoplasms/radiotherapy , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Doxorubicin/administration & dosage , Doxorubicin/adverse effects , Female , Humans , Lymphoma/pathology , Neoplasm Staging , Prednisolone/administration & dosage , Prednisolone/adverse effects , Scalp , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/secondary , Uterine Cervical Neoplasms/pathology , Vincristine/administration & dosage , Vincristine/adverse effects
4.
Gynecol Oncol ; 51(3): 408-10, 1993 Dec.
Article in English | MEDLINE | ID: mdl-8112654

ABSTRACT

The implantation of cervical cancer in an episiotomy scar is very rare. We present such a case in a patient with stage IIIB squamous cell carcinoma of the cervix. The tumor implantation responded only partially to chemotherapy and radiotherapy. Review of the literature revealed six cases of cervical cancer implanting in the episiotomy site. All followed a normal vaginal delivery. Early initial stage, small-size implantation lesion, and early surgical intervention seemed to be good prognostic factors.


Subject(s)
Carcinoma, Squamous Cell/etiology , Episiotomy/adverse effects , Uterine Cervical Neoplasms/etiology , Adult , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/radiotherapy , Cicatrix , Cisplatin/therapeutic use , Doxorubicin/therapeutic use , Female , Fluorouracil/therapeutic use , Humans , Pregnancy , Uterine Cervical Neoplasms/drug therapy , Uterine Cervical Neoplasms/radiotherapy
5.
Hum Pathol ; 23(3): 324-7, 1992 Mar.
Article in English | MEDLINE | ID: mdl-1555842

ABSTRACT

Renal oncocytoma can present with calcification seen on the plain roentgenogram. From a review of the literature (both before and after 1976, when the concept of oncocytoma was popularized in the English literature), 10 cases of calcification in association with renal oncocytoma were found. In three of these 10 cases, the calcifications could be grossly demonstrated on the plain roentgenogram; in the other seven cases, the calcifications were microscopic in nature. The presence of calcification in a renal tumor does not rule out the diagnosis of oncocytoma. Grossly, a renal oncocytoma has a brownish mahogany color. A case is presented in which simple excision of an oncocytoma resulted in a 33-year survival. In the future, excision instead of nephrectomy could become the standard treatment for these tumors.


Subject(s)
Adenoma/surgery , Calcinosis/surgery , Kidney Neoplasms/surgery , Adenoma/pathology , Adolescent , Calcinosis/pathology , Follow-Up Studies , Humans , Kidney Neoplasms/pathology , Male
6.
Ann Saudi Med ; 11(1): 67-72, 1991 Jan.
Article in English | MEDLINE | ID: mdl-17588059

ABSTRACT

Septal hemangioma is a rare cause of epistaxis and nasal obstruction. Ten cases were seen in our center over 25 years and constitute 31% of all cases of nasal hemangioma. The male to female ration was 2.4:1; patient age ranged between 14 and 63 years (average, 39 years). The main presenting symptom was epistaxis with progressive nasal obstruction. There was a positive history of trauma in 7 cases. Symptoms varied between 1.5 months to 4 years (average, 13 months). All tumors but one were located anteriorly in the septum and measured between 0.5 and 2 cm in diameter. Histologically they were well-defined benign neoplasms covered with stratified squamous epithelium and showed varying degrees of ulceration. In eight cases the core was composed of proliferating capillary-type vessels, and two were cavernous. Operative intervention is the treatment of choice, with recurrences likely in the event of incomplete excision (two of the ten cases recurred).

7.
Am J Surg Pathol ; 14(4): 379-83, 1990 Apr.
Article in English | MEDLINE | ID: mdl-1690954

ABSTRACT

Primary localized amyloidosis of the nose and nasopharynx is a rare disease. We present a case and review seven additional cases from the English literature. The ages of the patients ranged from 8 to 86 years; there was no sex predominance. Symptoms were nasal obstruction, epistaxis, and impaired hearing. Physical examination revealed a nasal mass or glue ears. The lesions were composed of amyloid and chronic inflammatory cells, mainly plasma cells. Ours is the first case of nasal amyloidosis in which the type of amyloid was determined immunohistochemically to be amyloid light chain (AL) lambda. The main treatment was surgical. Recurrences developed. Determination of the biochemical nature of this amyloid clarified its pathogenesis and may influence treatment. Amyloidosis should be considered in the differential diagnosis of nasal obstruction, epistaxis, and glue ears, even in the pediatric age group.


Subject(s)
Amyloidosis/metabolism , Nose Diseases/metabolism , Paranasal Sinus Diseases/metabolism , Amyloid/metabolism , Amyloidosis/diagnostic imaging , Amyloidosis/pathology , Child , Humans , Immunohistochemistry/methods , Male , Nose Diseases/diagnostic imaging , Nose Diseases/pathology , Paranasal Sinus Diseases/diagnostic imaging , Paranasal Sinus Diseases/pathology , Staining and Labeling , Tomography, X-Ray Computed
8.
Ear Nose Throat J ; 68(9): 660, 662-6, 668-72, 1989 Sep.
Article in English | MEDLINE | ID: mdl-2583034

ABSTRACT

Mycobacterial cervical lymphadenitis remains a diagnostic challenge for many clinicians despite current advances in diagnostic laboratory techniques. Although much has been done to prevent tuberculosis, cases of mycobacterial disease in endemic form still occur. Six hundred and forty-five patients with tuberculosis were diagnosed and treated at the American University of Beirut Medical Center during the period from 1970 to 1985. Twenty-nine (4.5%) of these patients had proven mycobacterial cervical lymphadenitis. We stress histopathologic examination as the single most important means for diagnosing mycobacterial cervical lymphadenitis. Operation in combination with antituberculous chemotherapy remain the treatments of choice.


Subject(s)
Lymphadenitis/diagnosis , Mycobacterium Infections/diagnosis , Tuberculosis, Lymph Node/diagnosis , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Humans , Infant , Male , Middle Aged , Neck , United States
9.
Am J Surg Pathol ; 11(3): 225-30, 1987 Mar.
Article in English | MEDLINE | ID: mdl-3826481

ABSTRACT

Breast sarcomas with giant cells and osteoid are rare and usually fatal. They should be distinguished from carcinomas with sarcomatous metaplasia. Our case is presented together with eight similar ones reported in the English literature. Their clinical, radiologic, gross, and histologic characteristics are analyzed. Most patients died within 1 1/2 years of diagnosis, survival apparently being related to the size of the tumor. Diagnosis is delayed because the tumor can be confused clinically and radiologically with a large fibroadenoma. Awareness of this problem, fine-needle aspiration, and computerized tomography may lead to earlier diagnosis and, consequently, improved survival. In our case, immunohistochemical studies supported the notion that the lesion was a primary sarcoma, rather than a carcinoma with sarcomatous metaplasia.


Subject(s)
Breast Neoplasms/pathology , Sarcoma/pathology , Adult , Female , Humans , Necrosis
10.
Int J Pediatr Nephrol ; 7(2): 99-100, 1986.
Article in English | MEDLINE | ID: mdl-3522459

ABSTRACT

An infant with hypokalemic alkalosis, hyperreninemia, aldosteronism, normal blood pressure and normal juxtaglomerular apparatus (JGA) is described. This infant, along with other similar patients reported in the literature, represents a new syndrome of renal alkalosis, clinically and chemically similar to Bartter's syndrome, but without hyperplasia of the JGA.


Subject(s)
Alkalosis/diagnosis , Bartter Syndrome/diagnosis , Hyperaldosteronism/diagnosis , Juxtaglomerular Apparatus/pathology , Kidney Diseases/diagnosis , Alkalosis/complications , Biopsy , Blood Pressure , Humans , Hyperaldosteronism/complications , Hypokalemia/complications , Infant , Kidney Diseases/pathology , Kidney Diseases/physiopathology , Kidney Glomerulus/pathology , Kidney Tubules/pathology , Male , Renin/blood , Syndrome
12.
Br J Rheumatol ; 24(1): 70-3, 1985 Feb.
Article in English | MEDLINE | ID: mdl-3872150

ABSTRACT

A young female with mixed connective tissue disease (MCTD) presented with the unusual occurrence of abdominal pseudolymphoma. Although the pseudolymphoma could be related to concomitant sicca complex, some data suggest that MCTD, as such, could carry a high incidence of malignancy.


Subject(s)
Abdominal Neoplasms/etiology , Lymphoma/etiology , Mixed Connective Tissue Disease/complications , Sjogren's Syndrome/complications , Abdominal Neoplasms/pathology , Adult , Antibodies, Antinuclear/analysis , Female , Humans , Lymph Nodes/pathology , Lymphoma/pathology , Mixed Connective Tissue Disease/immunology , Sjogren's Syndrome/immunology
13.
Hum Pathol ; 15(3): 238-43, 1984 Mar.
Article in English | MEDLINE | ID: mdl-6538178

ABSTRACT

The ultrastructural features of two testicular stromal tumors were compared with those of normal gonadal stroma. The two patients with tumor were 28 and 48 years old and had no endocrine abnormalities. No metastases or recurrences occurred after 32 and 12 months of follow-up, respectively. The tumors were composed of bundles of oval to spindle-shaped cells. Ultrastructurally, intracytoplasmic myofilaments were characteristic of the tumor cells, which resembled the contractile peritubular and interfollicular cells of normal testis and ovary. In normal testicular tissue, an intertubular mesenchymal cell may differentiate into a peritubular contractile cell or into an interstitial (Leydig) cell. Therefore, testicular stromal tumors with myofilaments may originate from an intertubular mesenchymal cell that is capable of differentiating into a cell with contractile elements.


Subject(s)
Cytoskeleton/ultrastructure , Testicular Neoplasms/ultrastructure , Testis/ultrastructure , Adult , Humans , Male , Microscopy, Electron , Middle Aged , Testicular Neoplasms/pathology
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