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1.
Eur J Cardiothorac Surg ; 40(4): 1022-4, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21353583

ABSTRACT

As previously well described in the literature, the intercostal muscle (ICM) flap can be used to buttress bronchial stumps following lung resection. We describe a harvesting technique of ICM flap which enabled a bi-lobectomy to be avoided in a patient with poor pulmonary function. The Key to this technique is the preservation of the neurovascular bundle. Therefore the flap is not divided anteriorly thereby differentiating it from any previous technique described.We have called it the 'bucket handle' technique, which was used to repair an intra-operative tear in bronchus intermedius. Its efficacy was tested to the full when the patient developed severe adult respiratory distress syndrome (ARDS) secondary to pseudomonas pneumonia and required high-pressure mechanical ventilation. This case demonstrates that ICM flap is an effective buttress to bronchial stumps or repairs and offers reassurance for optimal outcome due to its intact vascular pedicle.


Subject(s)
Bronchi/injuries , Bronchi/surgery , Intercostal Muscles/transplantation , Surgical Flaps , Aged , Bronchography/methods , Female , Humans , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Lymph Node Excision/adverse effects , Tomography, X-Ray Computed
2.
Oxid Med Cell Longev ; 3(3): 199-205, 2010.
Article in English | MEDLINE | ID: mdl-20716944

ABSTRACT

The aim of this study was to investigate if there was a link between the relaxant responses in saphenous vein (SV) and internal mammary artery (IMA) segments obtained from patients undergoing coronary artery bypass grafting and the patients' cardiovascular risk factors. Endothelium-(in)dependent relaxations were assessed by isometric tension studies. Endothelium-dependent relaxant responses were greater in IMA than SV and gender, smoking profile and history of hypertension but not diabetes appeared to have an influence on these responses. Endothelium-dependent relaxant responses in both IMA and SV were greater in males than females and relaxant responses in IMA segments were attenuated in smokers, whereas the opposite effect was noted in SV segments. Endothelium-dependent relaxant responses in SV were lower in patients with hypertension. Endothelium-independent relaxant responses were greater in IMA than SV. Endothelium-independent responses were greater in male patients' SV segments, but gender played no role in IMA segments. Diabetes had no effect on endothelium-independent responses in IMA, but SV segments from diabetic patients had greater responses. Neither conduit's endothelium-independent response was affected by hypertensive status. The relationship between risk factor status and endothelial responses is multifactorial, with gender, hypertension, diabetes and smoking status all contributing.


Subject(s)
Diabetes Mellitus/physiopathology , Endothelium, Vascular/physiology , Hypertension/physiopathology , Mammary Arteries/physiology , Saphenous Vein/physiology , Vasodilation/physiology , Adult , Aged , Aged, 80 and over , Coronary Artery Bypass , Endothelium, Vascular/physiopathology , Female , Humans , Male , Mammary Arteries/physiopathology , Middle Aged , Saphenous Vein/physiopathology , Sex Factors , Smoking/adverse effects
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