Serum calcitonin in renal transplant patients.

We obtained blood samples from 60 renal transplant patients from our transplant clinic and from control subjects for biochemical analyses. Cyclosporin levels were measured in whole blood. Serum levels of calcitonin, calcium, phosphate, albumin, urea, creatinine, and activity of alkaline phosphatase were determined. Serum calcitonin levels were significantly higher in renal transplant patients. There was no correlation between serum calcitonin levels and activity of serum alkaline phosphatase, or levels of serum calcium, phosphate, albumin, urea, creatinine or cyclosporin. Serum calcitonin also showed no correlation with patient age or transplant age.

Effect of selenium and vitamin E on iminodipropionitrile induced dyskinesia in rats.

The present study was undertaken to determine the effect of combination of selenium and vitamin E on experimentally induced dyskinesia in rats. The dyskinetic syndrome was produced in 4 groups of 6 male rats each weighing 250-300g by intraperitoneal (ip) administration of iminodipropionitrile (IDPN) in doses of 100 mg/kg body weight daily for 12 days. A group of 6 rats (group 1) served as control and received normal saline only. The rats in group 2 (IDPN only) received normal saline (ip) 30 minutes before the administration of IDPN. The animals in groups 3, 4 and 5 received selenous acid (5 mumol/kg), vitamin E (500 mg/kg p.o.) and a combination of selenous acid and vitamin E respectively, daily, 30 minutes before IDPN for 12 days. Twenty four hours after the last dose of IDPN, the dyskinetic behavior including vertical head movements (retrocollis), horizontal head movements (laterocollis), circling and backwalking of each rat was studied for a period of 10 minutes. Immediately after behavioral studies, the animals were sacrificed and brains were dissected out for the analysis of conjugated dienes, lipid hydroperoxides and vitamin E. The results of this study showed that treatment of rats with IDPN only for 12 days produced dyskinetic syndrome in all the rats characterized by vertical and horizontal head movements, circling and backwalking. Concomitant treatment of rats with vitamin E and selenium individually reduced IDPN induced dyskinesia, and the symptoms were almost completely absent when the combination of these two agents was used.(ABSTRACT TRUNCATED AT 250 WORDS)