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Tissue distribution of [3H]centpiperalone after oral administration.

Mukerjee, S S; Dey, S; Bhaduri, A P; Mukherjee, S K.

Indian J Biochem Biophys ; 17(5): 399-401, 1980 Oct.

Article in English | MEDLINE | ID: mdl-7251022

Subject(s)

Hypoglycemic Agents/metabolism , Piperazines/metabolism , Quinazolines/metabolism , Administration, Oral , Animals , Quinazolinones , Rats , Tissue Distribution

Chronic toxicity studies of a hypoglycemic compound: centperalone in rats & rhesus monkeys.

Mukerjee, S S; Sethi, N; Roy, A K; Srivastava, G N; Mukherjee, S K.

Indian J Exp Biol ; 17(12): 1346-9, 1979 Dec.

Article in English | MEDLINE | ID: mdl-120313

Subject(s)

Hypoglycemic Agents/toxicity , Piperazines/toxicity , Quinazolines/toxicity , Animals , Blood Chemical Analysis , Body Weight/drug effects , Female , Haplorhini , Macaca mulatta , Male , Quinazolinones , Rats

Effect of alloxan diabetes on some aspects of lipid metabolism in albino rats.

Mukerjee, S S; Murthi, P S; Garg, N K; Mukherjee, S K.

Acta Diabetol Lat ; 16(2): 111-8, 1979.

Article in English | MEDLINE | ID: mdl-484161

ABSTRACT

Administration of alloxan (40 mg/kg i.v.) caused a marked decrease in the lipolytic and esterolytic activities of rat aorta. This effect was completely reversed when the diabetic rats were treated with low doses of insulin (2-3 U/die) for 3 days. The insulin-dependence of esterolysis and lipolysis in rat aorta and the role of hydrolases in atherogenesis in experimental diabetes have been discussed.

Subject(s)

Diabetes Mellitus, Experimental/metabolism , Lipid Metabolism , Liver/metabolism , Alloxan/pharmacology , Animals , Aorta, Abdominal/metabolism , Aorta, Thoracic/metabolism , Blood Glucose/analysis , Carboxylic Ester Hydrolases/metabolism , Insulin/pharmacology , Rats

Activators of serum lipoprotein lipase in alloxan diabetic rats.

Mukerjee, S S; Mukherjee, S K.

Experientia ; 34(11): 1429-30, 1978 Nov 15.

Article in English | MEDLINE | ID: mdl-720463

ABSTRACT

The amount of free fatty acid (FFA) liberated with intralipid in post-heparin guinea-pig serum, when serum from alloxan diabetic rat is incubated, is higher than that liberated when serum from healthy rats is used. The above effect is probably due to larger quantities of lipoprotein lipase present in the diabetic serum.

Subject(s)

Diabetes Mellitus, Experimental/enzymology , Lipoprotein Lipase/blood , Animals , Enzyme Activation , Fatty Acids, Nonesterified/blood , Heparin , Humans , Rats

Chrinic toxicity studies of Centchroman in rats & rhesus monkeys.

Mukerjee, S S; Sethi, N; Srivastava, G N; Roy, A K; Nityanand, S; Mukherjee, S K.

Indian J Exp Biol ; 15(12): 1162-6, 1977 Dec.

Article in English | MEDLINE | ID: mdl-96022

Subject(s)

Benzopyrans/toxicity , Centchroman/toxicity , Animals , Body Weight/drug effects , Female , Haplorhini , Macaca mulatta , Male , Organ Size/drug effects , Rats , Time Factors

Effect of 2-piperazino-4(3H)-quinazolinone monoacetate on the tissue respiration, glucose uptake and lactic acid production by rat hemidiaphragm.

Mukerjee, S S; Mukherjee, S K.

Biochem Pharmacol ; 23(21): 3066-7, 1974 Nov 01.

Article in English | MEDLINE | ID: mdl-4429603

Subject(s)

Glucose/metabolism , Lactates/metabolism , Muscles/metabolism , Oxygen Consumption/drug effects , Piperazines/pharmacology , Quinazolines/pharmacology , Animals , Diaphragm/metabolism , Rats , Rats, Inbred Strains , Time Factors

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