Nanomaterial-Based Antimicrobial Coating for Biomedical Implants: New Age Solution for Biofilm-Associated Infections.

Recently, the upsurge in hospital-acquired diseases has put global health at risk. Biomedical implants being the primary source of contamination, the development of biomedical implants with antimicrobial coatings has attracted the attention of a large group of researchers from around the globe. Bacteria develops biofilms on the surface of implants, making it challenging to eradicate them with the standard approach of administering antibiotics. A further issue of current concern is the fast resurgence of resistance to conventional antibiotics. As nanotechnology continues to advance, various types of nanomaterials have been created, including 2D nanoparticles and metal and metal oxide nanoparticles with antimicrobial properties. Researchers from all over the world are using these materials as a coating agent for biomedical implants to create an antimicrobial environment. This comprehensive and contemporary review summarizes various metals, metal oxide nanoparticles, 2D nanomaterials, and their composites that have been used or may be used in the future as an antimicrobial coating agent for biomedical implants, as well as their succinct mode of action to combat biofilm-associated infection and diseases.

Germ cell ribonucleoprotein granules in different clades of life: From insects to mammals.

Ribonucleoprotein (RNP) granules are no newcomers in biology. Found in all life forms, ranging across taxa, these membrane-less "organelles" have been classified into different categories based on their composition, structure, behavior, function, and localization. Broadly, they can be listed as stress granules (SGs), processing bodies (PBs), neuronal granules (NGs), and germ cell granules (GCGs). Keeping in line with the topic of this review, RNP granules present in the germ cells have been implicated in a wide range of cellular functions including cellular specification, differentiation, proliferation, and so forth. The mechanisms used by them can be diverse and many of them remain partly obscure and active areas of research. GCGs can be of different types in different organisms and at different stages of development, with multiple types coexisting in the same cell. In this review, the different known subcategories of GCGs have been studied with respect to five distinct model organisms, namely, Drosophila, Caenorhabditis elegans, Xenopus, Zebrafish, and mammals. Of them, the cytoplasmic polar granules in Drosophila, P granules in C. elegans, balbiani body in Xenopus and Zebrafish, and chromatoid bodies in mammals have been specifically emphasized upon. A descriptive account of the same has been provided along with insights into our current understanding of their functional significance with respect to cellular events relating to different developmental and reproductive processes. This article is categorized under: RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Export and Localization > RNA Localization RNA in Disease and Development > RNA in Disease.

Land use patterns and urbanization in the holy city of Varanasi, India: a scenario.

Rapid urbanization and increasing land use changes due to population and economic growth in selected landscapes is being witnessed of late in India and other developing countries. The cities are expanding in all directions resulting in large-scale urban sprawl and changes in urban land use. The spatial pattern of such changes is clearly noticed on the urban fringes or city peripheral rural areas than in the city center. In fact, this is reflected in changing urban land use patterns. There is an urgent need to accurately describe land use changes for planning and sustainable management. In the recent times, remote sensing is gaining importance as vital tool in the analysis and integration of spatial data. This study intends to estimate land use pattern in a planned and unplanned urban setup and also to analyze the impact of change in land use pattern in the Varanasi urban environment. The results indicate that the planned urban setup had a higher tree cover to that of unplanned area in the Varanasi City, although a considerable disparity existed within the planned urban setups. The results emphasize the need to critically review concepts of urban planning and give more consideration to the preservation and management of urban tree cover/greenspace.