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Cogn Neuropsychiatry ; 19(3): 226-40, 2014.
Article in English | MEDLINE | ID: mdl-24131203

ABSTRACT

INTRODUCTION: This is one of the very few studies to investigate the specific executive function/processing speed component of response initiation in subjects at familial risk (FR) for psychosis, and the first such study in subjects at clinical risk (CR) for psychosis. METHODS: Participants (N = 177) were members of the general population-based Northern Finland 1986 Birth Cohort in the following four groups: FR for psychosis (n = 62), CR for psychosis (n = 21), psychosis (n = 25) and control subjects (n = 69). The response initiation of these groups was compared in three different tests: Semantic fluency, Stockings of Cambridge and Spatial working memory. RESULTS: The two risk groups did not differ significantly from control group, but differed from, and outperformed the psychosis group in semantic fluency response initiation. CONCLUSIONS: Response initiation deficits were not evident in a non-help seeking psychosis high-risk sample.


Subject(s)
Executive Function/physiology , Memory, Short-Term/physiology , Psychotic Disorders/epidemiology , Psychotic Disorders/physiopathology , Adult , Analysis of Variance , Family Health , Female , Finland/epidemiology , Humans , Infant, Newborn , Longitudinal Studies , Male , Risk Factors , Semantics , Young Adult
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