[Arterial hypertension and coronary heart disease: clinical and functional aspects].

The subjects of the study were 196 men with verified coronary heart disease (CHD). The subjects were divided into 4 groups: 1) patients without arterial hypertension (AH); 2) patients with mild AH, 3) patients with moderate AH, 4) patients with severe AH (SAH). All the patients were tested by means of veloergometry. The study found that the presence and severity of AH affected functional condition of cardiovascular system and clinical manifestations in patients with CHD. The appearance and aggravation of AH in CHD patients: 1) diminished clinical manifestations (angina), and elevated frequency of ECG signs of myocardial ischemia; there was significant growth of the proportion of patients with painless myocardial ischemia and ventricular arrhythmias associated with physical activity; 2) while causing moderate decrease of physical tolerance, substantially decreased the economy of cardiovascular system functioning, associated mostly with 'pressure overload"; pressor reaction effectiveness lowered; 3) worsened disturbances of recovery period, which manifested in prolongation of the time necessary for systolic pressure to return to initial level. These peculiarities were most prominent in patients with CHD and SAH, which allows considering this combination to be a new condition, requiring new approaches to evaluation of its clinical course and therapy.

[Arterial hypertension and ischemic heart disease: clinico-echocardiographic aspects]. / Arterial'naia gipertoniia i ishemicheskaia bolezn' serdtsa: kliniko-ékhokardiograficheskie aspekty.

Doppler M-mode echocardiography was made in 156 males with ischemic heart disease (IHD) verified coronarographically. The patients were normotensive or had mild, moderate and severe arterial hypertension (AH) (groups 1, 2, 3 and 4, respectively). The groups were similar by functional anginal class. Echocardiographic findings were in many cases similar. This supports the hypothesis that IHD and AH are closely related. However, the addition of AH to atherosclerotic affection of the coronary artery or atherosclerosis rise in the presence of AH is associated with development of myocardial hypertrophy which is registered at echocardiography and correlates in severity with severity of AH. Myocardial hypertrophy is, on the one side, compensatory as it prevents dilation of the left ventricle and impairment of its contractility rising at later stage of the disease with depletion of the myocardial and coronary reserves, but, on the other side, it promotes diastolic dysfunction of the left ventricle, lowers its performance. The above phenomena are most pronounced in combination of IHD with severe AH. This combination presents a new qualitative state and, therefore, needs new approaches to its correction.

[Application of high information technologies in predicting outcomes of cardiovascular diseases]. / K voprosu ispol'zovaniia vysokikh inforamtsionnykh tekhnologii v prognozirovanii serdechno-sosudistykh zabolevanii.

The authors review their studies conducted for many years on cardiological prognostication in the context of the republican program "Cardiology" performed in the Udmurt Republic. The lines of the research and results obtained are described.

[Use of a new exercise test in the early period of myocardial infarction: rationale and experience]. / Obosnovanie i opyt primeneniia novoi nagruzochnoi proby v rannie sroki infarkta miokarda.

A new gradual exercise test (gravimetric test (GT)) has been proposed to use in early myocardial infarction (MI). GT is more physiologically and safe than a bicycle ergometry test, its sensitivity being 54.9%. The use of GT allows one to detect a group of patients with subsequent slower readaptation to exercises on post-MI days 7-10 and to make appropriate correction of treatment.

[Dynamic exercise tests in the assessment of rehabilitation in patients with myocardial infarction]. / Dinamicheskie nagruzochnye proby v otsenke reabilitatsii bol'nykh infarktom miokarda.

176 patients with myocardial infarction were subjected to a sequence of tests: an original gravimetric test on the disease day 7-10, bicycle ergometry on day 12-20, repeated bicycle ergometry on days 30-35 and 100-120. The results of the investigations performed in different times were interrelated. This helped to make accurate prognosis of recovering ability in 85% of patients. This system of dynamic control demonstrated that the greatest positive effects on exercise tolerance are reached in combined use of intravenous blood radiation with He-Ne laser and combined chemotherapy. Nitroglycerin+heparin combination is the least effective. Nitroglycerin+heparin in combination with metabolism correctors is of moderate efficacy.