ABSTRACT
<p><b>OBJECTIVE</b>To innovatively establish a new platform of myocardial ischemia-reperfusion injury (MIRI) animal model by observing abnormal savda carrier MIRI indicators, and to observe changes of myocardial ultrastructure.</p><p><b>METHODS</b>According to Uyghur medical theories, an abnormal savda carrier animal model was established and confirmed using multifactor, and then MIRI models set up. Totally 36 male white SD rats were randomly divided into the normal sham-operation group, the normal operation group, the model sham-operation group, and the model operation group, 9 in each group. ECG changes, myocardial enzymes (CK-MB), and cardiac troponin (cTnT), and ultramicrostructures were observed.</p><p><b>RESULTS</b>Compared with the normal sham-operation group, some damage of ultramicrostructures occurred in heart muscles of rats in the normal operation group and the model operation group, such as lowered myoplasm density, loosely arranged myofilament, dilated myofibris, reduced mitochondria number, vacuole and swelling mitochondrion. Ultramicrostructural damage of cardiac muscle cells was more severe in rats of the model operation group. Compared with the normal sham-operation group, CK-MB and cTnT increased in the normal operation group with statistical difference (P < 0.01). Compared with the normal sham-operation group, there was no statistical difference in CK-MB or cTnT in the model sham-operation group (P > 0.05). Compared with the model operation group, CK-MB and cTnT obviously decreased in the model sham-operation group and the normal operation group with statistical difference (all P < 0.01).</p><p><b>CONCLUSION</b>Abnormal savda carrier MIRI model established in this experiment could provide favorable conditions for further MIRI intervention treatment.</p>
Subject(s)
Animals , Male , Rats , Disease Models, Animal , Medicine, Traditional , Myocardial Reperfusion Injury , Myocardium , Myocytes, Cardiac , Rats, Sprague-DawleyABSTRACT
BACKGROUND: Constrictive pericarditis is a slow progressive fibrosis of the pericardium leading to a variety of symptoms and signs over time. The disease poses a diagnostic challenge; restrictive cardiomyopathy and other syndromes associated with right-sided pressure abnormalities share similar symptoms and clinical findings. Pericardiectomy is considered the treatment of choice for constrictive pericarditis. Here we studied the effects of total radical pericardiectomy on hemodynamics in 37 patients diagnosed with constrictive pericarditis. METHODS: Between 2005 and 2012 thirty-seven patients, 31 males and 6 females, age range 15 to 69 years, underwent total pericardiectomy for constrictive pericarditis. Diagnosis was made on the basis of clinical, pathological and diagnostic modalities-ECG, x-rays, magnetic resonance imaging, computed tomography and echocardiogram. The surgical approach was median sternotomy and surgery was conducted without cardiopulmonary bypass. RESULTS: Postoperative outcomes showed overall improvement in the majority of patients. Hemodynamics-stroke volume, cardiac output, ejection fraction, central venous pressure-were all measurably improved postoperatively. There was no postoperative mortality. CONCLUSION: Radical pericardiectomy is a demonstrably useful procedure for correction of hemodynamic abnormalities and improvement of overall heart function in symptomatic patients with constrictive pericarditis.
