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J Am Chem Soc ; 123(19): 4459-68, 2001 May 16.
Article in English | MEDLINE | ID: mdl-11457231

ABSTRACT

Phospholipids containing trans-unsaturated fatty acid residues are the major products of the thiyl radical attack on L-alpha-phosphatidylcholine from soybean lecithin in homogeneous solution or in liposomes (LUVET). Thiyl radicals act as the catalyst for the cis-trans isomerization, and the number of catalytic cycles depends on the reaction conditions. The presence of approximately 0.2 mM oxygen does not influence the reaction outcome but accelerates the efficiency of cis-trans isomerization in homogeneous solution. Under these conditions, the PUFA peroxidation is found to be unimportant. A detailed study of the isomerization of methyl linoleate including product studies indicates the formation of a small amount of conjugated dienes that act as inhibitors. Indeed, all-trans-retinol substantially retarded the isomerization process.


Subject(s)
Fatty Acids, Unsaturated/chemistry , Phospholipids/chemistry , Sulfhydryl Compounds/chemistry , Catalysis , Chromatography, Gas , Free Radicals/chemistry , Isomerism , Linoleic Acids/chemistry , Membranes, Artificial , Phosphatidylcholines/chemistry , Glycine max/chemistry , tert-Butyl Alcohol/chemistry
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