Analysis of the connective tissue matrix and proteolytic activity of primary varicose veins.

PURPOSE: Valvular incompetence and venous wall abnormalities have been suggested as primary etiologic factors responsible for the development of varicose veins. This study was conducted to evaluate the connective tissue constituents of greater saphenous varicosities. Proteolytic activity, a factor that can lead to matrix degradation and cause weakening and dilation of the venous wall, was also assessed. METHODS: The collagen and elastin contents of 16 nonthrombophlebitic greater saphenous varicose veins (VV) and seven normal greater saphenous veins (NV) were quantified. In addition, four duplex scanning-confirmed competent segments of greater saphenous veins (i.e., potential varicose veins [PV]) affected by varicosis at alternate sites were analyzed. Proteolytic activity was determined by zymography and radiolabeled substrate assay. RESULTS: The content of collagen was significantly increased in the VV and PV compared with NV (VV = 189 +/- 7 mg/gm, PV = 189 +/- 9 mg/gm vs NV = 144 +/- 10 mg/gm, p < 0.05). Conversely, the elastin content in the VV and PV was significantly reduced (VV = 53 +/- 3 mg/gm, PV = 50 +/- 4 mg/gm vs NV = 74 +/- 4 mg/gm, p < 0.05). The collagen to elastin ratio demonstrated an alteration in VV and PV compared with NV (VV = 3.7 +/- 0.3, PV = 3.9 +/- 0.4 vs NV = 2.0 +/- 0.2, p < 0.05). Casein and gelatin zymography did not demonstrate significant qualitative differences in the enzymatic activities among the three groups. Quantitative analysis of the elastase activity in the venous tissues was similarly not appreciably altered (VV = 5.1 +/- 0.2 U/gm, PV = 5.3 +/- 0.2 U/gm vs NV = 5.7 +/- 0.3 U/gm). CONCLUSION: A significant increase in the collagen content and a significant reduction in the elastin content of VV were demonstrated. The net increase in the collagen/elastin ratio is indicative of an imbalance in the connective tissue matrix. The biochemical profile of PV was similar to VV and significantly different from NV. These preliminary data support the presence of connective tissue abnormalities before valvular insufficiency. In addition, the absence of an increase in the proteolytic activity excludes enzymatic matrix degradation as an essential component in the formation of venous varicosities.

Pseudoaneurysm after carotid endarterectomy.

An unusual case of recurrent infected pseudoaneurysm seven years following carotid endarterectomy is described. The initial pseudoaneurysm was treated with resection and Dacron patch angioplasty. Recurrence one year later was caused by infection of the patch. Treatment with resection and autologous saphenous vein patch angioplasty resulted in cure. Pseudoaneurysm formation after carotid endarterectomy is unusual and can generally be traced to technical factors. Of the fifty reported cases, only seven (14%) resulted from or were associated with local infection. Avoidance of prosthetic patch material may help prevent this complication. If it does occur, management should include precise angiographic diagnosis, vascular control through previously unoperated areas, complete debridement of all necrotic and infected pseudocapsule, and, if necessary, reconstruction with autologous vein.

The value of cardiac monitoring during peripheral arterial stress testing in the surgical management of peripheral vascular disease.

Eighty-six patients presenting with lower extremity pain on exertion underwent treadmill peripheral arterial stress testing with simultaneous cardiac monitoring. Of these patients 19 went on to have vascular reconstruction. Cardiac monitoring of peripheral arterial stress testing is a sensitive method of revealing occult cardiac disease in these high risk patients. It provides valuable information that can contribute to the surgical management of these patients. Specifically, ischemic exercise EKG patterns developed in 69.2% of patients with non-ischemic resting EKG patterns. Further, 80% of patients denying cardiopulmonary symptoms during peripheral arterial stress testing developed ischemic exercise EKG patterns. Of nine patients with significant ischemia on treadmill testing, two had vascular reconstruction postponed until after coronary artery bypass, four had extra-anatomic bypass. Two cardiac-related complications occurred, both in patients with ischemic exercise EKG patterns undergoing femoral-popliteal bypass.

Experience with 49 consecutive dacron interposition mesocaval shunts. A unified approach to portasystemic decompression procedures.

In 1973, a plan was developed to manage all patients with bleeding esophageal varices who required portasystemic decompression with a Dacron interposition mesocaval shunt procedure. This paper has analyzed 7 years of such experience in 49 consecutive patients. Forty-eight were cirrhotic, 26 (53 percent) required emergency shunting, and 6 were in Child's class A, 13 were in class B and 30 were in class C. Overall, operative mortality was 11 of 49 patients (22.4 percent). Ten of the 11 deaths were of patients in class C and all but one of the patients (90.9 percent) had undergone an emergency operation. Sixteen patients had episodes of significant postshunt recurrent bleeding. Such bleeding occurring within 30 days of operation was a function of severe hepatic, hematologic, and general metabolic derangements. Recurrent hemorrhage occurring after discharge was a function of shunt thrombosis (four patients) or alcoholic recidivism. Twelve patients (31.6 percent) had significant postshunt encephalopathy. Cumulative 5 year survival was 49.3 percent. These data emphasize the high risk of mortality in class C patients operated on an emergency basis. Postoperative encephalopathy is a significant problem with this shunting procedure.

Peripheral arterial emboli and factors in their recurrence rate.

One hundred six patients who underwent a total of 141 operations, on 156 limbs for peripheral arterial emboli from 1964 to 1979 were studied. The average age of the patients was 68.5 years. The source of the emboli in 76.4% of the patients was arteriosclerotic heart disease and atrial fibrillation. The presenting clinical symptoms and signs were the most accurate determinate of limb salvage. Our overall limb salvage was 86.5% and in the survivor population 93.9%. The overall hospital mortality was 21.7%. There were much higher morbidity and mortality rates associated with each subsequent embolic event. Particular attention was paid to factors related to recurrent emboli. The use of antigoagulants in the post embolectomy period does not have a statistically significant effect of preventing recurrent emboli.

Long-term results of operative therapy for aortoiliac disease.

Over a period of 11 1/2 years, 140 patients were operated on for aortoiliac disease; 81 had coexisting superficial femoral artery occlusions (combined segment disease). Patients with combined segment disease were older, had twice the incidence of diabetes, and significantly more rest pain and gangrene on presentation. Aortic bifurcation grafts were placed in 114 patients. Relief of rest pain and threatened gangrene was uniformly good. However, relief of claudication was significantly poorer in patients with combined segment disease. There were 11 "late" thrombotic graft occlusions. Six grafts with distal anastamoses to the external iliacs failed because of limb outflow problems, while five grafts to the common femoral position exhibited more diffuse problems. Late graft failures were due to progression of disease and not problems intrinsic to the grafts. Cumulative patency rates were 98.0% at one year and 94.6% at three years.

Dacron grafting from the aorta to the distal profunda femoria arteries via the obturator foramina.

We discuss the possibility of the use of the obturator foramina as routes and the distal profunda femoris arteries as sites for anastomosis in the presence of infected grafts in the groins as a successful solution to an otherwise tragic complication of arterial grafting.

Combined aortoiliac and femoropopliteal occlusive disease.

In a series of 140 patients operated upon for aortoiliac occlusive disease over 11 1/2 years, 81 had concomitant occlusion of the superficial femoral artery. These 81 patients with combined segment disease were studied with particular emphasis on the relief of presenting symptoms by an aortic bypass procedure alone. Fifty-three patients underwent only aortic bypass and could be fully evaluated postoperatively. Ninety-six per cent presenting with rest pain or ischemic changes obtained complete relief of these sympotms. All 53 patients presented with claudication, and 88.7 per cent either had complete relief or improved to the point that no further theapy was needed. The results of this study confirm the efficacy of restoration of proximal flow to the profunda femoris arteries as the primary therapeutic goal in patients with combined segment disease.

Intravascular coagulation in surgical procedures on the abdominal aorta.

A prospective study was performed on 32 consecutive patients undergoing elective operations on the abdominal aorta. Dacron prosthetic grafts were used to replace resected abdominal aortic aneurysms or to bypass aorta-iliac occlusive disease. Complete coagulation studies were performed preoperatively, immediately postoperatively and 24 hours postoperatively. Twenty to 30 per cent of the patients had significant postoperative alterations in prothrombin time, partial thromboplastin time and platelet count. Fibrin monomer, fibrin split products and plasminogen were abnormal in 40 to 80 per cent of the patients postoperatively. Results of preoperative studies showed no significant abnormalities. One of the 32 patients had mild clinical evidence of disseminated intravascular coagulation postoperatively, which was treated with 5 units of heparin per kilogram per hour. Results of the study indicate that aortic grafting procedures frequently produce intravascular coagulation, either local or disseminated. In most patients, this is offset by activation of the fibrinolytic system. However, clinically significant sequelae may result, requiring prompt recognition and treatment.

Disseminated intravascular coagulation as a complication of abdominal aortic aneurysm repair.

A retrospective review was done of all patients undergoing surgical repair of abdominal aortic aneurysm (AAA) on whom coagulation studies were obtained. Those patients with laboratory documented disseminated intravascular coagulation (DIC) were selected and their clinical records reviewed. This included 7 patients studied in the periods 1964-1965 and January 1971-July 1973. Of these 7 cases, 4 occurred in patients undergoing emergency operation for ruptured aneurysm and 3 were in elective cases. All 7 patients exhibited clinical evidence of abnormal bleeding, while 6 of the 7 progressed rapidly to renal shutdown. The seventh patient recovered spontaneously. Of the 6 patients with full blown clinical and laboratory evidence of DIC, 2 recovered. Both cases received heparin therapy and multiple hemodialyses. A third patient was started on heparin but died at 36 hours in heart failure. All 3 patients receiving heparin showed clinical cessation of abnormal bleeding and disappearance of soluble fibrin monomer complexes within 24 hours of starting therapy. The study suggests a higher incidence of DIC than has previously been appreciated in both the emergency and elective repair of AAA. The prompt recognition and treatment of this complication may reverse the abnormal intravascular clotting, minimize its more serious results and avoid futile and dangerous operative intervention.