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Bioorg Med Chem Lett
; 16(4): 1045-8, 2006 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-16289817
ABSTRACT
The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity for the NK-1 receptor and show good antagonistic activity in the gerbil foot-tapping assay.