Unusual presentation of seborrheic keratosis: A case report of giant pigmented lesion on the forehead.

INTRODUCTION AND IMPORTANCE: Seborrheic keratosis (SK) is a common benign epidermal tumor usually presenting as small, non-pigmented lesions on the skin. However, giant SK presenting as a pigmented variant is a rare occurrences, with limited documented cases in medical literature. CASE PRESENTATION: Here, we present a case report of a 70 year old female patient with an unusual giant warty cutaneous lesion prompting excisional biopsy. Histopathological examination revealed pigmented proliferative basaloid cell and pseudohorn cysts, characteristic of SK. Notably, the lesion exhibited pigmentation, adding to the rarity of the giant forms of SK case. CLINICAL DISCUSSION: Giant pigmented seborrheic keratosis (GPSK) is an uncommon form that shares clinical and dermatoscopic features, frequently causing misdiagnosis as malignant melanoma. CONCLUSION: Thus this report underscores the importance recognizing such atypical presentations of SK and highlights the need for histological evaluation to diagnose such variants.

A glimpse at locally advanced melanomas in the settings of poverty: pathologist's viewpoint.

Cutaneous melanoma is the most aggressive cancer of the skin arising from pigment-producing cells, known as melanocytes. It is notorious for spreading early to distant locations. Survival of patients with melanoma largely depends on the thickness of the lesion at the primary site thus spotting it early is crucial. Early diagnosis of melanoma, with an improved quality of life and treatment outcomes, is being achieved in some developed nations through screening and health education. On the contrary, as practicing pathologists in a resource-scarce country, we frequently encounter patients with locally advanced melanoma manifesting as ulceration, bleeding, fungation, and bone erosion. Several factors, including low socioeconomic status, medical mistrust, inaccessibility of health facilities, and absent screening and surveillance services can be attributed to the delayed diagnosis. Therefore to alleviate the burden and complications caused by the late presentation of cutaneous melanoma, an urgent massive community mobilization, information campaigning, and the provision of accessible basic primary health care are urgently needed.