A Case Report on Pseudo-Internuclear Ophthalmoplegia: A Rare Manifestation of Myasthenia Gravis.

A 41-year-old male with recently diagnosed diabetes mellitus type 2 presented with drooping of the left eyelid with double vision and was found to have an adduction deficit in the left eye and nystagmus in the abducting right eye during conjugated gaze: a left-sided internuclear ophthalmoplegia (INO). A medial longitudinal fasciculus (MLF) lesion was excluded exhaustively with brain imaging. The possibility of a pseudo-INO was considered. The autoantibody profile demonstrated positivity to acetylcholine receptor (AChR) antibody. Repetitive nerve stimulation (RNS) and electromyography (EMG) were unremarkable. An acetylcholinesterase inhibitor trial showed a significant improvement in the ocular symptoms. Hence, the diagnosis of ocular myasthenia was confirmed. There was no evidence of a thymic hyperplasia. Herein, we discuss pseudo-INO being an atypical presentation of myasthenia gravis (MG), emphasizing the importance of having a strong suspicion despite unremarkable test results.

A Case Report of Takotsubo Cardiomyopathy With Dengue.

A 74-year-old woman with well-controlled hypertension and dyslipidemia with acute fever was diagnosed with dengue infection. She had non-anginal central chest pain which was associated with ST elevation and T inversions in V1 to V6 with prolonged QT interval. Her high-sensitivity troponin was elevated. There was echocardiographic evidence of severe left ventricular dysfunction (ejection fraction 35%; Simpson method) with apical ballooning suggestive of takotsubo cardiomyopathy. No left ventricular basal hyperkinesia was noted. The patient was managed as per the national dengue guidelines of Sri Lanka. Her cardiac condition was managed conservatively. She did not experience dengue complications such as dengue shock syndrome or dengue hemorrhagic fever or pulmonary edema secondary to severe LV dysfunction. The clinical symptoms and echocardiographic findings of takotsubo cardiomyopathy resolved parallel to dengue fever.

A Case Report of Kikuchi Fujimoto Disease as an Antecedent Illness of Systemic Lupus Erythematosus in a Male.

Kikuchi Fujimoto disease (KFD) is a rare benign self-limiting condition described in young females characterized by lymphadenopathy and fever. It has been associated with several infective and autoimmune diseases, among which systemic lupus erythematosus (SLE) is relatively common. Kikuchi disease could occur either as a proceeding illness or as a coexisting illness with SLE. The presence of necrotizing lymphadenitis is appreciated in the histological specimen to confirm the diagnosis. Anti-nuclear antibody (ANA) positivity implicates a possible correlation with SLE or recurrence of the pre-existing disease. This clinical presentation needs to be evaluated thoroughly to prevent misdiagnosis and inappropriate treatment. Although Kikuchi disease generally warrants supportive treatment, steroids and immune therapy play a role in treating this persistent and recurrent disease. Long-term surveillance is mandatory for the early detection of sinister pathologies.

Rhinocerebral Mucormycosis with Extensive Cranial Nerve Palsies in a Diabetic Patient.

Mucormycosis is a common opportunistic fungal infection with a disseminated nature. Despite being a devastating disease with the involvement of multiple upper cranial nerves, the implications of the seventh cranial nerve have been infrequently encountered. Although the radiological evidence with sinus destruction supports the diagnosis, histological specimen showing fungal elements confirms it as fungal culture doesn't always demonstrate a high diagnostic yield. Early detection and multimodal treatment are mandatory to prevent detrimental outcomes and to control the disease progression. We, hereby present a rare case of rhinocerebral mucormycosis with multiple cranial nerve involvement including the facial nerve in a 70-year-old female with long-standing poorly controlled diabetes mellitus.