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Leuk Lymphoma ; 45(8): 1687-9, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15370226

ABSTRACT

Natural killer (NK) cell lymphomas are rare in the USA and Europe but more common in Asia and Central America although very rare among children. We report a case of Epstein-Barr virus-positive NK lymphoma/leukemia, that showed peculiar features represented by a very long clinical course with a significant interval between the first clinical signs and the diagnosis, detection of neoplastic cells in the peripheral blood but not in the bone marrow, and good response to treatment and clinical outcome.


Subject(s)
Epstein-Barr Virus Infections/complications , Killer Cells, Natural/pathology , Leukemia/diagnosis , Lymphoma/diagnosis , Antineoplastic Agents, Phytogenic/therapeutic use , Bone Marrow/immunology , Bone Marrow/pathology , Bone Marrow/virology , Child, Preschool , DNA, Viral/analysis , Female , Herpesvirus 4, Human/genetics , Herpesvirus 4, Human/pathogenicity , Humans , Immunophenotyping , Killer Cells, Natural/immunology , Killer Cells, Natural/virology , Leukemia/drug therapy , Leukemia/virology , Lymphoma/drug therapy , Lymphoma/virology , Treatment Outcome , Vinblastine/therapeutic use
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