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1.

MITOCHONDRIAL MYOPATHY: A NEW THERAPEUTIC APPROACH.

Hagiu, B A; Mungiu, C.

Rev Med Chir Soc Med Nat Iasi ; 120(2): 400-3, 2016.

Article in English | MEDLINE | ID: mdl-27483725

ABSTRACT

Restoration of deoxyribonucleic acid in mitochondrial myopathies may occur after a mechanical or chemical injury of striated muscle or by endurance training. Therapies with enzymes, gene therapies, or treatments with substances that stimulate mitochondrial biogenesis are used at the moment. Genesis of mitochondria may also come from myonuclei by releasing the nuclear respiratory factor-1/2 during muscle contractions. Multiplying of myonuclei depends on muscle satellite cell activation. Since the electromyostimulation increase the number of circulating stem cells that may participate in the genesis of new muscle fibers (adding to the deposit of specific stem cells of the muscle), and intermittent hypoxia stimulates the proliferation of muscle satellite cells, we propose to combine the two processes for the treatment of mitochondrial myopathies. Respective combined therapy may be useful for restoring damaged mitochondria by drug side effects.

Subject(s)

Electric Stimulation Therapy , Genetic Therapy , Hypoxia , Mitochondrial Myopathies/therapy , DNA/metabolism , Electric Stimulation Therapy/methods , Genetic Therapy/methods , Humans , Mitochondria/metabolism , Mitochondrial Myopathies/genetics , Mitochondrial Myopathies/pathology , Muscle Fibers, Skeletal/metabolism , Treatment Outcome

2.

[Clinical and experimental data on conduction anesthesia and analgesia with pethidine]. / Date clinice si experimentale asupra anesteziei si analgeziei de conducere cu petidina.

Sandu, L; Mungiu, C O; Ionescu, C; Constandache, F; Teodoru, C; Molotiu, N; Ianas, A.

Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir ; 32(1): 75-80, 1983.

Article in Romanian | MEDLINE | ID: mdl-6224242

Subject(s)

Analgesia , Anesthesia, Conduction , Meperidine/pharmacology , Pain/drug therapy , Humans

3.

[Testing the toxicity of pesticides in laboratory animals]. / Testarea toxicitatii pesticidelor pe animale de laborator.

Gavat, V; Alexa, L; Filipiuc, M; Mungiu, C.

Rev Med Chir Soc Med Nat Iasi ; 82(4): 623-7, 1978.

Article in Romanian | MEDLINE | ID: mdl-756583

Subject(s)

Insecticides/toxicity , Animals , Animals, Laboratory , Rabbits , Rats , Toxaphene/toxicity , Trichlorfon/toxicity

4.

[Pharmacological experiments on the psychotropic action of a sulfonium salt cationic radical derived from phenothiazine]. / Experimentari farmacologice privind actiunea psihotropa a unui radical cation sare de sulfoniu derivat de fenotiazina

Oita, N; Oniscu, C; Iacobovici, A; Zilberman, D; Mungiu, C.

Rev Med Chir Soc Med Nat Iasi ; 81(1): 105-8, 1977.

Article in Romanian | MEDLINE | ID: mdl-866822

Subject(s)

Brain/drug effects , Phenothiazines/pharmacology , Animals , Behavior, Animal/drug effects , Brain/metabolism , Mice , Oxygen Consumption/drug effects , Respiratory System/drug effects

5.

The influence of some antibiotics on hexokinase and pyruvate-kinase activity in the rat liver and kidney.

Popovici, G G; Mungiu, C; Trandafirescu, M; Botez, E; Cernatescu, D; Caraman, D; Ababei, L.

Arch Int Pharmacodyn Ther ; 193(1): 80-6, 1971 Sep.

Article in English | MEDLINE | ID: mdl-5111330

Subject(s)

Chloramphenicol/pharmacology , Hexokinase/metabolism , Kidney/enzymology , Liver/enzymology , Neomycin/pharmacology , Pyruvate Kinase/metabolism , Streptomycin/pharmacology , Adenosine Triphosphate/biosynthesis , Animals , Erythromycin/pharmacology , Glycolysis , In Vitro Techniques , Penicillin G/pharmacology , Rats

6.

[Correlations between the secondary effects of some antibiotics and metabolic changes in animal cells]. / Corelatii între effcte secundare ale unor antibiotice si modificãri metabolice în celula animala.

Popovici, G G; Mungiu, C; Ababei, L.

Rev Med Chir Soc Med Nat Iasi ; 75(3): 545-52, 1971.

Article in Romanian | MEDLINE | ID: mdl-5110798

Subject(s)

Anti-Bacterial Agents/adverse effects , Metabolism/drug effects , Animals , Bone Marrow/metabolism , Brain/metabolism , Chloramphenicol/adverse effects , Enzymes/metabolism , Erythromycin/adverse effects , Glycolysis/drug effects , Humans , In Vitro Techniques , Kidney/metabolism , Liver/metabolism , Neomycin/adverse effects , Oxygen Consumption/drug effects , Penicillins/adverse effects , Streptomycin/adverse effects

7.

[Effect of chloramphenicol on respiration and glycolysis of rat brain homogenates]. / Influenta cloramfenicolului aspra respiratiei si glicolizei omogenatului de creier de sobolan.

Mungiu, C; Popovici, G G; Trandafirescu, M; Botez, E; Caraman, D; Ababei, L.

Fiziol Norm Patol ; 17(2): 177-82, 1971.

Article in Romanian | MEDLINE | ID: mdl-5578187

Subject(s)

Brain/metabolism , Chloramphenicol/pharmacology , Glycolysis/drug effects , Oxygen Consumption/drug effects , Animals , Hexokinase/metabolism , Phosphorus/metabolism , Rats

8.

[Study of basal metabolism and oxygen consumption of brain tissue after administration of anticonvulsant substances]. / Cercetarea metabolismului bazal si a consumului de oxigen al tesutului cerebral dupa administrarea unor substante anticonvulsivante.

Moisa, L; Pavelescu, M; Mungiu, C; Dobre, A.

Rev Med Chir Soc Med Nat Iasi ; 75(1): 149-54, 1971.

Article in Romanian | MEDLINE | ID: mdl-5552550

Subject(s)

Anticonvulsants/pharmacology , Basal Metabolism/drug effects , Brain/drug effects , Ethylenediamines/pharmacology , Pyrimidines/pharmacology , Animals , Brain/metabolism , Mice , Oxygen Consumption/drug effects , Rats

9.

Influence of some antibiotics on stationary NAD and NADP concentrations in rat liver and kidney.

Popovici, G G; Mungiu, C; Filip, M; Botez, E; Ababei, L.

Arch Int Pharmacodyn Ther ; 188(1): 73-8, 1970 Nov.

Article in English | MEDLINE | ID: mdl-4394967

Subject(s)

Kidney/metabolism , Liver/metabolism , NADP/metabolism , NAD/metabolism , Neomycin/pharmacology , Streptomycin/pharmacology , Animals , Chloramphenicol/pharmacology , Erythromycin/pharmacology , Glucosephosphate Dehydrogenase/metabolism , Kidney/drug effects , Liver/drug effects , N-Glycosyl Hydrolases/metabolism , Penicillins/pharmacology , Rats , Stimulation, Chemical

10.

[Comparative effects of pure chloramphenicol and chloramphenicol succinate on respiration and glycolysis of rat liver homogenate]. / Efecte comparative ale cloramfenicolului pur si ale succinatului de ficat de sobolan.

Mungiu, C; Popovici, G G; Filip, M; Botez, E; Ababei, L.

Fiziol Norm Patol ; 16(3): 281-5, 1970.

Article in Romanian | MEDLINE | ID: mdl-4317654

Subject(s)

Chloramphenicol/pharmacology , Glycolysis/drug effects , Liver/metabolism , N-Glycosyl Hydrolases/metabolism , NAD/metabolism , Oxygen Consumption/drug effects , Rats , Succinates/pharmacology , Animals

11.

The mechanism of action of streptomycin on hepatic glucose-6-P-NADP-oxido-reductase (G6PDH) activity.

Popovici, G G; Mungiu, C; Botez, E; Caraman, D; Ababei, L.

Arch Int Pharmacodyn Ther ; 180(1): 126-33, 1969 Jul.

Article in English | MEDLINE | ID: mdl-5357000

Subject(s)

Glucosephosphate Dehydrogenase/metabolism , Liver/enzymology , Streptomycin/pharmacology , Adenosine Triphosphate/pharmacology , Benzoates/pharmacology , Cysteine/pharmacology , Enzyme Activation , Glucosephosphate Dehydrogenase/antagonists & inhibitors , Liver/drug effects , Methionine/pharmacology

12.

[Effect of neomycin and streptomycin on respiration and glycolysis at the level of the diaphragm in rats]. / Influenta neomicienei si streptomicinei asupra respiratiei si glicolizei la nivelul diafragmului de sobolan.

Popovici, G G; Mungiu, C; Botez, E; Caraman, D; Ababei, L.

Fiziol Norm Patol ; 15(6): 545-50, 1969.

Article in Romanian | MEDLINE | ID: mdl-5380890

Subject(s)

Diaphragm/metabolism , Glycolysis/drug effects , Muscles/metabolism , Oxygen Consumption/drug effects , Animals , Rats

13.

The influence of some antibiotics on glucose-6-P-NADP-oxido-reductase (G6PDH) activity.

Popovici, G G; Mungiu, C; Botez, E; Ababei, L.

Arch Int Pharmacodyn Ther ; 171(1): 102-8, 1968 Jan.

Article in English | MEDLINE | ID: mdl-5646007

Subject(s)

Chloramphenicol/pharmacology , Erythromycin/pharmacology , Glucosephosphate Dehydrogenase/metabolism , Kidney/enzymology , Liver/enzymology , Lung/enzymology , Neomycin/pharmacology , Penicillin G/pharmacology , Spleen/enzymology , Streptomycin/pharmacology , Animals , Chloromercuribenzoates/pharmacology , Kidney/drug effects , Liver/drug effects , Lung/drug effects , Rats , Spleen/drug effects , Yeasts/enzymology

14.

[Changes of the acetylcholine-cholinesterase system of the brain after administration of some anticonvulsant substances]. / Modificarea sistemului acetilcolina-colinesteraza din creier dupa administrarea unor substante anticonvulsivante.

Moisa, L; Pavelescu, M; Mungiu, C; Dobre, A.

Rev Med Chir Soc Med Nat Iasi ; 73(3): 681-7, 1967.

Article in Romanian | MEDLINE | ID: mdl-5619544

Subject(s)

Acetylcholine/metabolism , Anticonvulsants/pharmacology , Brain/drug effects , Cholinesterases/metabolism , Animals , Brain/metabolism , Mice

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