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1.
Skeletal Radiol ; 52(10): 1803-1814, 2023 Oct.
Article in English | MEDLINE | ID: mdl-35840815

ABSTRACT

Cancer is a leading cause of death, with the spine being the most common site for skeletal metastasis. The spine is also a site for primary malignancy, such as sarcoma and chordoma, as well as non-neoplastic pathologies. An accurate diagnosis of spinal neoplastic diseases is crucial in determining appropriate management. With the advent of personalised oncology, the need to establish a definitive histopathologic diagnosis to guide management is more important than ever. Percutaneous biopsy has proven to be safe and efficient in establishing a reliable histopathologic diagnosis. The spine, however, can be a challenging site to biopsy, due to the proximity of critical neurovascular, respiratory, and gastrointestinal structures. Successful spine biopsy depends on several factors: suspected diagnosis, size of the lesion, location within the spine, modality for best imaging guidance, operator experience, technical equipment considerations, and desired approach and associated limitations. The specimen must also be obtained with a biopsy route amenable to any future surgical intervention, with surgical input often sought, frequently in a multidisciplinary setting, to confirm procedure-specific goals and expectations. Knowledge of the requisite local anatomy, procedural and patient-specific indications, and contraindications and various approaches that may be used to access different segments of the spine, potential complications, and how to address these are keys to a successful percutaneous spinal biopsy, even in the most challenging of circumstances.


Subject(s)
Spinal Diseases , Spine , Humans , Retrospective Studies , Spine/diagnostic imaging , Spine/surgery , Spine/pathology , Biopsy/methods , Spinal Diseases/diagnostic imaging , Spinal Diseases/pathology
2.
J Radiol Case Rep ; 11(4): 30-37, 2017 Apr.
Article in English | MEDLINE | ID: mdl-28567183

ABSTRACT

Throughout recent years, Gabapentin has become increasingly used for the treatment of neuropathic pain. We report on a case of a 31 year old female who presented to the emergency department with unilateral leg pain, weakness, and swelling after increasingly titrating her Gabapentin dosage over three weeks. Magnetic resonance imaging confirmed the presence of myositis confined to the left thigh and the patient's symptoms and laboratory abnormalities resolved following Gabapentin cessation. While Gabapentin-induced myositis and rhabdomyolysis is a rare entity, it should be a diagnostic consideration for radiologists, particularly in the absence of infection or trauma.


Subject(s)
Amines/adverse effects , Analgesics/adverse effects , Cyclohexanecarboxylic Acids/adverse effects , Myositis/chemically induced , Myositis/diagnostic imaging , Neuralgia/drug therapy , gamma-Aminobutyric Acid/adverse effects , Adult , Biomarkers/blood , Computed Tomography Angiography , Contrast Media , Diagnosis, Differential , Female , Gabapentin , Humans , Leg , Magnetic Resonance Imaging , Ultrasonography, Doppler
4.
AJR Am J Roentgenol ; 203(1): W103-9, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24951221

ABSTRACT

OBJECTIVE: The objective of our study was to discover the types and incidence of artifacts in dual-energy CT (DECT) using datasets of 50 consecutive patients who underwent a four-limb DECT protocol for the evaluation of suspected gout. Identification of artifacts and techniques for artifact reduction are discussed. CONCLUSION: Artifacts commonly occur in DECT performed for gout assessment but are usually readily recognizable. For 90% of the patients in our study who underwent imaging for suspected gout, DECT showed some type of artifact, with nail bed and skin artifacts being the most common.


Subject(s)
Artifacts , Gout/diagnostic imaging , Tomography, X-Ray Computed/methods , Adult , Aged , Algorithms , Female , Humans , Male , Middle Aged , Radiographic Image Interpretation, Computer-Assisted
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