The queers are all right: a content analysis of LGBTQIA + mental health on TikTok.

The formation of online communities instils a sense of connectedness which can ameliorate the mental health concerns that result from minority stressors for lesbian, gay, queer, intersex, asexual, and other diverse genders/sexualities (LGBTQIA+). The aim of this study was to explore how LGBTQIA + people communicate social and mental health concerns on TikTok. It was anticipated that factors affecting mental health, such as minority stressors and community connectedness, would be addressed by the videos collected. Engagement statistics, demographics and content analysis were used to describe the 50 most-viewed videos across the top five related hashtags: #genderidentity, #lgbtqawareness, #sexualidentity, #lgbtmentalhealth, and #transmentalhealth. The content analysis indicates that TikTok is used as a way for members of the LGBTQIA + community to connect with each other and enhance feelings of community connectedness, which research shows may buffer the effects of minority stressors. Engagement with social media can be especially beneficial for those who may not be able to connect in the real-world. Further interactions, such as analysis of the comment section, should be investigated to develop a fuller understanding of how LGBTQIA + TikTok users respond to these contents.

Widening the care gap? An international comparison of care leaving in the time of COVID-19.

Following COVID-19, young people who transitioned to adulthood from different types of alternative care (care leavers) experienced an exacerbation of the challenges they had before the pandemic. The purpose of this international survey was to explore the range of policy and service responses that have or have not been implemented around the world to support care leavers during COVID-19. Responses were collected from care-leaving researchers from 19 countries toward the end of 2020. Half of the participating countries reported that the state had issued directives about measures that should be taken to support care leavers following COVID-19 outbreak, but only three reported actual changes in legislation. Additionally, nongovernmental organizations (NGOs) in various countries took steps to guide and support care leavers, while two thirds reported on special initiatives that were mounted. The most common change in practices during COVID-19 was the postponement of exits from care, and the second was an increase in contact from workers. These findings are critically discussed in relation to the impact of policy changes on an already vulnerable group. In particular, we indicate that there appears to be a widening care gap: Some countries with stronger leaving care legal and policy frameworks pre-COVID-19 were more inclined to introduce additional supportive measures during the pandemic, whereas some with underdeveloped services tended not to increase the support. By contrast, other countries used this crisis to develop services that were not available before. The creativity and flexibility in the services provided during the COVID-19 outbreak are required on an ongoing basis and thus should be implemented overall. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

MicroSweat: A Wearable Microfluidic Patch for Noninvasive and Reliable Sweat Collection Enables Human Stress Monitoring.

Stress affects cognition, behavior, and physiology, leading to lasting physical and mental illness. The ability to detect and measure stress, however, is poor. Increased circulating cortisol during stress is mirrored by cortisol release from sweat glands, providing an opportunity to use it as an external biomarker for monitoring internal emotional state. Despite the attempts at using wearable sensors for monitoring sweat cortisol, there is a lack of reliable wearable sweat collection devices that preserve the concentration and integrity of sweat biomolecules corresponding to stress levels. Here, a flexible, self-powered, evaporation-free, bubble-free, surfactant-free, and scalable capillary microfluidic device, MicroSweat, is fabricated to reliably collect human sweat from different body locations. Cortisol levels are detected corresponding to severe stress ranging from 25 to 125 ng mL-1 averaged across multiple body regions and 100-1000 ng mL-1 from the axilla. A positive nonlinear correlation exists between cortisol concentration and stress levels quantified using the perceived stress scale (PSS). Moreover, owing to the sweat variation in response to environmental effects and physiological differences, the longitudinal and personalized profile of sweat cortisol is acquired, for the first time, for various body locations. The obtained sweat cortisol data is crucial for analyzing human stress in personalized and clinical healthcare sectors.

Nurturing children's development through healthy eating and active living: Time for policies to support effective interventions in the context of responsive emotional support and early learning.

Fostering the growth, development, health, and wellbeing of children is a global priority. The early childhood period presents a critical window to influence lifelong trajectories, however urgent multisectoral action is needed to ensure that families are adequately supported to nurture their children's growth and development. With a shared vision to give every child the best start in life, thus helping them reach their full developmental potential, we have formed the International Healthy Eating Active Living Matters (HEALing Matters) Alliance. Together, we form a global network of academics and practitioners working across child health and development, and who are dedicated to improving health equity for children and their families. Our goal is to ensure that all families are free from structural inequality and oppression and are empowered to nurture their children's growth and development through healthy eating and physical activity within the context of responsive emotional support, safety and security, and opportunities for early learning. To date, there have been disparate approaches to promoting these objectives across the health, community service, and education sectors. The crucial importance of our collective work is to bring these priorities for early childhood together through multisectoral interventions, and in so doing tackle head on siloed approaches. In this Policy paper, we draw upon extensive research and call for collective action to promote equity and foster positive developmental trajectories for all children. We call for the delivery of evidence-based programs, policies, and services that are co-designed to meet the needs of all children and families and address structural and systemic inequalities. Moving beyond the "what" is needed to foster the best start to life for all children, we provide recommendations of "how" we can do this. Such collective impact will facilitate intergenerational progression that builds human capital in future generations.

Severe intraventricular hemorrhage causes long-lasting structural damage in a preterm rabbit pup model.

BACKGROUND: Intraventricular hemorrhage causes significant lifelong mortality and morbidity, especially in preterm born infants. Progress in finding an effective therapy is stymied by a lack of preterm animal models with long-term follow-up. This study addresses this unmet need, using an established model of preterm rabbit IVH and analyzing outcomes out to 1 month of age. METHODS: Rabbit pups were delivered preterm and administered intraperitoneal injection of glycerol at 3 h of life and approximately 58% developed IVH. Neurobehavioral assessment was performed at 1 month of age followed by immunohistochemical labeling of epitopes for neurons, synapses, myelination, and interneurons, analyzed by means of digital quantitation and assessed via two-way ANOVA or Student's t test. RESULTS: IVH pups had globally reduced myelin content, an aberrant cortical myelination microstructure, and thinner upper cortical layers (I-III). We also observed a lower number of parvalbumin (PV)-positive interneurons in deeper cortical layers (IV-VI) in IVH animals and reduced numbers of neurons, synapses, and microglia. However, there were no discernable changes in behaviors. CONCLUSIONS: We have established in this preterm pup model that long-term changes after IVH include significant wide-ranging alterations to cortical organization and microstructure. Further work to improve the sensitivity of neurocognitive testing in this species at this age may be required. IMPACT: This study uses an established animal model of preterm birth, in which the rabbit pups are truly born preterm, with reduced organ maturation and deprivation of maternally supplied trophic factors. This is the first study in preterm rabbits that explores the impacts of severe intraventricular hemorrhage beyond 14 days, out to 1 month of age. Our finding of persisting but subtle global changes including brain white and gray matter will have impact on our understanding of the best path for therapy design and interventions.

Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries.

Perinatal brain injuries, including encephalopathy related to fetal growth restriction, encephalopathy of prematurity, neonatal encephalopathy of the term neonate, and neonatal stroke, are a major cause of neurodevelopmental disorders. They trigger cellular and molecular cascades that lead in many cases to permanent motor, cognitive, and/or behavioral deficits. Damage includes neuronal degeneration, selective loss of subclasses of interneurons, blocked maturation of oligodendrocyte progenitor cells leading to dysmyelination, axonopathy and very likely synaptopathy, leading to impaired connectivity. The nature and severity of changes vary according to the type and severity of insult and maturation stage of the brain. Microglial activation has been demonstrated almost ubiquitously in perinatal brain injuries and these responses are key cell orchestrators of brain pathology but also attempts at repair. These divergent roles are facilitated by a diverse suite of transcriptional profiles and through a complex dialogue with other brain cell types. Adding to the complexity of understanding microglia and how to modulate them to protect the brain is that these cells have their own developmental stages, enabling them to be key participants in brain building. Of note, not only do microglia help build the brain and respond to brain injury, but they are a key cell in the transduction of systemic inflammation into neuroinflammation. Systemic inflammatory exposure is a key risk factor for poor neurodevelopmental outcomes in preterm born infants. Based on these observations, microglia appear as a key cell target for neuroprotection in perinatal brain injuries. Numerous strategies have been developed experimentally to modulate microglia and attenuate brain injury based on these strong supporting data and we will summarize these.

Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury.

Midkine (MK) is a small secreted heparin-binding protein highly expressed during embryonic/fetal development which, through interactions with multiple cell surface receptors promotes growth through effects on cell proliferation, migration, and differentiation. MK is upregulated in the adult central nervous system (CNS) after multiple types of experimental injury and has neuroprotective and neuroregenerative properties. The potential for MK as a therapy for developmental brain injury is largely unknown. This review discusses what is known of MK's expression and actions in the developing brain, areas for future research, and the potential for using MK as a therapeutic agent to ameliorate the effects of brain damage caused by insults such as birth-related hypoxia and inflammation.

A pilot study investigating the impact of a caffeine-nap on alertness during a simulated night shift.

Consuming coffee immediately prior to a nap, known as a caffeine-nap, has been shown to improve alertness during the day, but it is unknown whether a caffeine-nap is effective at reducing sleep inertia during the night. A simulated shiftwork cross-over laboratory study was conducted whereby participants (N = 6, 4 F, 21-36y) consumed 200 mg of caffeine, or decaffeinated coffee (placebo), immediately prior to a 30 min nap opportunity at 03:30 h. Compared to placebo, the caffeine-nap resulted in improved vigilant attention and subjective fatigue in the 45 min post-nap opportunity. The caffeine-nap may be useful in reducing sleep inertia in shift workers who nap on nightshift.

Transitioning care-leavers with mental health needs: 'they set you up to fail!'

BACKGROUND: Children in the UK care system often face multiple disadvantages in terms of health, education and future employment. This is especially true of mental health where they present with greater mental health needs than other children. Although transition from care - the process of leaving the local authority as a child-in-care to independence - is a key juncture for young people, it is often experienced negatively with inconsistency in care and exacerbation of existing mental illness. Those receiving support from child and adolescent mental health services (CAMHS), often experience an additional, concurrent transfer to adult services (AMHS), which are guided by different service models which can create a care gap between services. METHOD: This qualitative study explored care-leavers' experiences of mental illness, and transition in social care and mental health services. Twelve care-leavers with mental health needs were interviewed and data analysed using framework analysis. RESULTS: Sixteen individual themes were grouped into four superordinate themes: overarching attitudes towards the care journey, experience of social care, experience of mental health services and recommendations. CONCLUSIONS: Existing social care and mental health teams can improve the care of care-leavers navigating multiple personal, practical and service transitions. Recommendations include effective Pathway Planning, multiagency coordination, and stating who is responsible for mental health care and its coordination. Participants asked that youth mental health services span the social care transition; and provide continuity of mental health provision when care-leavers are at risk of feeling abandoned and isolated, suffering deteriorating mental health and struggling to establish new relationships with professionals. Young people say that the key to successful transition and achieving independence is maintaining trust and support from services.

The 'dance' of kinship care in England and Ireland: Navigating a course between regulation and relationships / El "baile" del acogimiento en familia extensa en Inglaterra e Irlanda: Navegando entre la reglamentación y las relaciones

Ha habido un aumento importante de la utilización del acogimiento formal en familia extensa en el Reino Unido y en Irlanda en los últimos 20 años. Este trabajo describe algunos de los motivos del "crecimiento orgánico" del acogimiento en familia extensa y las múltiples dinámicas que lo han conformado. Se muestra que el acogimiento con familiares ha crecido relativamente de un modo lento en el sistema de protección más regulado de Inglaterra en comparación con el sistema menos regulado de Irlanda. El análisis de estas diferentes trayectorias indica: que allí donde hay una fuerte tendencia a la regulación la elección de los miembros individuales de la familia pueden tener un impacto en respuesta a la provisión estatal, que las diferencias culturales en la importancia que se da a los vínculos familiares puede jugar un papel en los procesos de decisión y que las variaciones en los niveles de regulación y apoyo pueden influir en el perfil del sistema de asistencia. También sirve para destacar que las relaciones pueden ser el pegamento que acerque los acogimientos formales en familia extensa y también el que los mantenga unidos. La reglamentación (y el modo de interpretarla sobre el terreno) puede influir en el clima de elecciones del cuidador para comenzar y seguir, pero no puede determinar dichas elecciones. Evidentemente se necesita reglamentación, pero parece sensato no ver ésta como una panacea en cuanto a su influencia. La cultura, en sus diversas acepciones parece también jugar un papel. La realización de más estudios comparativos puede enseñarnos más acerca de este "baile" del acogimiento en familia extensa y el equilibrio de factores reglamentarios y "culturales" (AU)

There has been a significant growth in the use of formal kinship care in the UK and Ireland in the last 20 years. The paper charts some of the reasons for the 'organic growth' of kinship care and the multiple dynamics that have shaped this. It shows that kinship care has grown relatively slowly in the more regulated care system of England, compared to the less regulated system in Ireland. Examination of these different trajectories suggests that: where the tendency to regulation is strong the choices of individual family members may also have an impact in response to state provision; cultural differences in the importance of family ties may play a part in decision-making processes; and that variations in levels of regulation and support may impact on the profile of the care system. It also serves to highlight that relationships may be the glue that brings formal kinship placements together and they may also be the glue that holds them together. Regulation (and how it is interpreted on the ground) can influence the climate of choices of the carer to start or keep going, but it cannot determine those choices. Clearly, regulation is required, but it seems wise not to see regulation as all-conquering in terms of influence. 'Culture' in a range of senses seems also to play a part. Further comparative study may reveal more about this 'dance' of kinship care and its balancing of regulatory and 'cultural' factors (AU)