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Anticancer Res ; 41(11): 5761-5766, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34732449

ABSTRACT

BACKGROUND/AIM: Prognostic factors of hypopharyngeal carcinoma have been reported previously. However, recurrent cases of this disease occurring within 6 months of treatment have been excluded or poorly documented in many studies. We aimed to evaluate the prognostic factors of hypopharyngeal carcinoma recurrence within 6 months. PATIENTS AND METHODS: A total of 120 patients were eligible for this retrospective study. Recurrent cases of hypopharyngeal carcinoma occurring within 6 months of treatment were evaluated and compared with non-recurrent cases. RESULTS: Recurrence within 6 months was detected in 28/50 cases. In univariate analyses, classification markers (pT≥4a and cN≥2b) were statistically significant prognostic factors for early recurrence (p=0.04 and p=0.04, respectively); however, only pT≥4a was predictive of recurrence in multivariate analyses (p=0.02). CONCLUSION: Risk stratification according to the prognostic factor pT≥4a will allow physicians to identify patients who should be followed meticulously within the first 6 months.


Subject(s)
Hypopharyngeal Neoplasms/pathology , Neoplasm Recurrence, Local , Squamous Cell Carcinoma of Head and Neck/secondary , Aged , Disease Progression , Disease-Free Survival , Female , Humans , Hypopharyngeal Neoplasms/mortality , Hypopharyngeal Neoplasms/therapy , Male , Middle Aged , Neoplasm Staging , Retrospective Studies , Risk Assessment , Risk Factors , Squamous Cell Carcinoma of Head and Neck/mortality , Squamous Cell Carcinoma of Head and Neck/therapy , Time Factors , Treatment Outcome
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