Atypical intrinsic neural timescale in the left angular gyrus in Alzheimer's disease.

Alzheimer's disease is characterized by cognitive impairment and progressive brain atrophy. Recent human neuroimaging studies reported atypical anatomical and functional changes in some regions in the default mode network in patients with Alzheimer's disease, but which brain area of the default mode network is the key region whose atrophy disturbs the entire network activity and consequently contributes to the symptoms of the disease remains unidentified. Here, in this case-control study, we aimed to identify crucial neural regions that mediated the phenotype of Alzheimer's disease, and as such, we examined the intrinsic neural timescales-a functional metric to evaluate the capacity to integrate diverse neural information-and grey matter volume of the regions in the default mode network using resting-state functional MRI images and structural MRI data obtained from individuals with Alzheimer's disease and cognitively typical people. After confirming the atypically short neural timescale of the entire default mode network in Alzheimer's disease and its link with the symptoms of the disease, we found that the shortened neural timescale of the default mode network was associated with the aberrantly short neural timescale of the left angular gyrus. Moreover, we revealed that the shortened neural timescale of the angular gyrus was correlated with the atypically reduced grey matter volume of this parietal region. Furthermore, we identified an association between the neural structure, brain function and symptoms and proposed a model in which the reduced grey matter volume of the left angular gyrus shortened the intrinsic neural time of the region, which then destabilized the entire neural timescale of the default mode network and resultantly contributed to cognitive decline in Alzheimer's disease. These findings highlight the key role of the left angular gyrus in the anatomical and functional aetiology of Alzheimer's disease.

Cortico-striatal activity associated with fidget spinner use: an fMRI study.

Fidget spinners are said to be a very successful toy, and it's said that it has a good impact on attention for children with ADHD and hand motor control. However, there is limited scientific evidence to support these claims, and there is a lack of data on neurobiological responses to rotating fidget spinners. To better understand the mechanism whereby fidget spinners affect motor behavior, we tried to identify the neural correlates of rotating fidget spinners using functional magnetic resonance imaging and non-magnetic fidget spinners with five types of ease of rotation. As a result, we confirmed that the pre/postcentral gyrus, middle temporal gyrus, supplementary motor area (SMA), cerebellum, and striatum are activated when rotating spinners. Furthermore, the SMA was activated more with easier-to-rotate spinners. Additionally, a psychophysiological interaction analysis revealed increased functional connectivity between the SMA and the caudate while rotating fidget spinners compared to just holding them. These results suggest that the fine motor control associate with spinning a fidget spinner is supported by the cortico-striatal circuits involved in planning and reward.

Long-term changes in cortical representation through perceptual learning of spectrally degraded speech.

Listeners can adapt to acoustically degraded speech with perceptual training. The learning processes for long periods underlies the rehabilitation of patients with hearing aids or cochlear implants. Perceptual learning of acoustically degraded speech has been associated with the frontotemporal cortices. However, neural processes during and after long-term perceptual learning remain unclear. Here we conducted perceptual training of noise-vocoded speech sounds (NVSS), which is spectrally degraded signals, and measured the cortical activity for seven days and the follow up testing (approximately 1 year later) to investigate changes in neural activation patterns using functional magnetic resonance imaging. We demonstrated that young adult participants (n = 5) improved their performance across seven experimental days, and the gains were maintained after 10 months or more. Representational similarity analysis showed that the neural activation patterns of NVSS relative to clear speech in the left posterior superior temporal sulcus (pSTS) were significantly different across seven training days, accompanying neural changes in frontal cortices. In addition, the distinct activation patterns to NVSS in the frontotemporal cortices were also observed 10-13 months after the training. We, therefore, propose that perceptual training can induce plastic changes and long-term effects on neural representations of the trained degraded speech in the frontotemporal cortices. These behavioral improvements and neural changes induced by the perceptual learning of degraded speech will provide insights into cortical mechanisms underlying adaptive processes in difficult listening situations and long-term rehabilitation of auditory disorders.

Neural correlates of subjective comprehension of noise-vocoded speech.

Under an acoustically degraded condition, the degree of speech comprehension fluctuates within individuals. Understanding the relationship between such fluctuations in comprehension and neural responses might reveal perceptual processing for distorted speech. In this study we investigated the cerebral activity associated with the degree of subjective comprehension of noise-vocoded speech sounds (NVSS) using functional magnetic resonance imaging. Our results indicate that higher comprehension of NVSS sentences was associated with greater activation in the right superior temporal cortex, and that activity in the left inferior frontal gyrus (Broca's area) was increased when a listener recognized words in a sentence they did not fully comprehend. In addition, results of laterality analysis demonstrated that recognition of words in an NVSS sentence led to less lateralized responses in the temporal cortex, though a left-lateralization was observed when no words were recognized. The data suggest that variation in comprehension within individuals can be associated with changes in lateralization in the temporal auditory cortex.