Increase in serum concentrations of inhibin in early onset pre-eclampsia with intrauterine growth restriction.

AIM: Recently, it has been hypothesized that reduced placental blood flow in early pregnancy causes changes in endothelial function, leading to pre-eclampsia. To clarify this clinically, we assessed serum concentrations of inhibin and uric acid in pre-eclamptic women compared with those of normotensive pregnant women. METHODS: One hundred and forty normotensive pregnant women (at 20-41 weeks' gestation) and 50 women with pre-eclampsia (at 24-41 weeks' gestation) were the study subjects. Pre-eclamptic women were classified according to the new criteria for pregnancy-induced hypertension produced by the Japanese Society of Obstetrics and Gynecology (JSOG). Serum concentrations of uric acid and inhibin were measured enzymatically and by radioimmunoassay, respectively. RESULTS: Serum concentrations of inhibin and uric acid in the pre-eclamptic women were significantly higher than in gestational age-matched normotensive pregnant women. There were significant correlations among inhibin and uric acid, blood pressure and birth weight. According to JSOG criteria, of the 50 pre-eclamptic women, 18 were early onset (EO), including 16 cases complicated by intrauterine growth restriction (IUGR), and 32 cases were late onset, including 12 cases complicated by IUGR. In the patients with EO and IUGR, serum concentrations of inhibin, but not uric acid, were significantly elevated as compared with those of the other pre-eclamptic women. CONCLUSION: The results suggest that an increase in the serum concentration of inhibin seen in EO pre-eclampsia, together with IUGR, might be a cause of reduced placental blood flow.

Campinas: a tendência da cárie dentária em 3 períodos no tempo 1961-1976; 1976-1992; 1992-2002 / Campinas: tendency of dental caries during three periods of time 1961-1976; 1976-1992; 1992-2002

Analisaram-se dados secundários de levantamentos realizados em três períodos de tempo (1961-1976; 1976-1992; 1992-2002) na cidade de Campinas objetivando verificar a saúde bucal de pré-escolares e escolares (3a14 anos). os exames epidemiológicos relativos à cárie dentária foram realizados seguindo recomendações da OMS. Foram realizados testes estatísticos utilizando a correlação de Spearman (p<0,05) correlacionando a porcentagem de crianças livres de cárie além do ceod e CPOD e os períodos de tempo. Entre os anos de 1961 até 2002, o ceod para a idade de 5 anos passou de 5,48 para 1,68 (redução de 69,34 por cento), sendo que em 1961 foi encontrado 12 por cento de indivíduos livres de cárie aumentando esta porcentagem para 56,2 por cento no ano de 2002. O índice de CPOD para crianças de 12 anos passou de 7,36 (1961) para 1,34 em 2002 (redução de 81,3 por cento) e uma porcentagem de 49,8 por cento foi encontrada para indivíduos livres de cárie neste ano...