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1.
J UOEH ; 35(3): 213-8, 2013 Sep 01.
Article in Japanese | MEDLINE | ID: mdl-24077590

ABSTRACT

A 54 year old Japanese man was introduced to Saiseikai General hospital for an evaluation of an abnormal chest X-ray film. Abnormal soft tissue area was observed in the mediastinum surrounding anterior area of the trachea on chest CT. Because the mediastinal tumor showed slow enlargement after temporal decrease and surgical resection of the tumor was performed 3 years after the first visit. Pathologically, diffuse proliferation of oval-shaped plasmacytic or small lymphocytic cells with eccentrically-located nuclei with rough chromatin were observed in the tumor. Immunohistochemically, these cells were positive for CD20, weakly positive for IgM, negative for CD3, CD5, CD10, suggesting lymphoplasmacytic lymphoma (LPL). The patient was treated with rituximab after the surgical treatment, and showed no exacerbation for 3.5 years after surgery. LPL localized to the paratracheal mediastinum is rare, and a surgical approach is important for prompt and proper diagnosis.


Subject(s)
Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/surgery , Trachea , Waldenstrom Macroglobulinemia/diagnosis , Waldenstrom Macroglobulinemia/surgery , Antibodies, Monoclonal, Murine-Derived/administration & dosage , Antigens, CD20/analysis , Antineoplastic Agents/administration & dosage , Biomarkers, Tumor/analysis , Combined Modality Therapy , Humans , Immunoglobulin M/analysis , Immunohistochemistry , Male , Mediastinal Neoplasms/pathology , Middle Aged , Rituximab , Tomography, X-Ray Computed , Treatment Outcome , Waldenstrom Macroglobulinemia/pathology
2.
Endocr J ; 53(6): 841-51, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17001108

ABSTRACT

There are many clinical and experimental reports demonstrating that estrogens and insulin interact when affecting their target organs. Estrogen receptors consist of two isoforms, estrogen receptors-alpha (ER-alpha) and -beta (ER-beta), but their roles in insulin-induced glucose uptake in mature adipose tissue have yet to be clarified. To evaluate the roles of ER-alpha, expressed predominantly in adipocytes, we have investigated the effects of estradiol (E2), an ER-alpha selective agonist (PPT), and its selective antagonist (MPP) on glucose uptake and insulin action in 3T3-L1 adipocytes. 3T3-L1 adipocytes were exposed to E2 or PPT and/or MPP at different concentrations. The cells were then subjected to 2-deoxy-D-glucose transport assay, western blot analysis, or RT-PCR analysis. Treatment of these cells with E2 or PPT resulted in biphasic effects on glucose transport, that is high (10(-5) M or 3 x 10(-6) M each) and low (10(-8) M) doses produced inhibition and stimulation, respectively. The favorable effect observed at 10(-8) M of E2 was diminished by treatment with MPP. Western bolt analysis revealed that these effects of E2, PPT and MPP paralleled the level of IRS-1 tyrosine phosphorylation. However, IRS-1 serine phosphorylation, suppressor of cytokine signaling (SOCS)-1,-2,-3 and protein tyrosine phosphatase 1B (PTP1B) expression did not change compared to control subjects. Our data clearly show that ER-alpha contributes to insulin stimulated glucose uptake through regulation of the tyrosine phosphorylation of IRS-1 protein.


Subject(s)
Estrogen Receptor alpha/physiology , Insulin Resistance , Phosphoproteins/metabolism , Protein-Tyrosine Kinases/metabolism , 3T3-L1 Cells , Animals , Deoxyglucose/pharmacokinetics , Estradiol/pharmacology , Estrogen Receptor alpha/agonists , Estrogen Receptor alpha/antagonists & inhibitors , Estrogen Receptor beta/metabolism , Insulin Receptor Substrate Proteins , Mice , Phenols , Phosphorylation , Piperazine , Piperazines/pharmacology , Protein Tyrosine Phosphatase, Non-Receptor Type 1 , Protein Tyrosine Phosphatases/metabolism , Pyrazoles/pharmacology , Suppressor of Cytokine Signaling Proteins/metabolism
3.
Int J Hematol ; 75(1): 67-71, 2002 Jan.
Article in English | MEDLINE | ID: mdl-11843294

ABSTRACT

We report a case of therapy-related myelodysplastic syndrome (t-MDS) in adult T-cell lymphoma. A 69-year-old man suffered from cutaneous adult T-cell lymphoma, which was treated with radiation to the skin and combination chemotherapy of CHOP-V-MMV and VEPA-B. After 14 months of these therapies, anemia and thrombocytopenia appeared, and bone marrow aspiration smears showed immature myeloblasts, dysplastic erythroblasts, and micromegakaryocytes. Therapy-related MDS of refractory anemia with an excess of blasts was diagnosed. Cytogenetic study of the bone marrow cells showed 5q- and additional abnormalities. Rearrangement of the MLL gene was observed in the bone marrow cells. Mutations of N-ras codons at 12,13, and 61, p53 tumor suppressor gene, and monoclonal integration of human T-lymphotrophic virus -1 provirus DNA were not observed in the bone marrow cells. The patient died of pneumonia 21 months after diagnosis of cutaneous adult T-cell lymphoma.


Subject(s)
Anemia, Refractory, with Excess of Blasts/etiology , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Lymphoma, T-Cell, Cutaneous/complications , Radiotherapy/adverse effects , Acute Disease , Aged , Anemia, Refractory, with Excess of Blasts/genetics , Anemia, Refractory, with Excess of Blasts/virology , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bleomycin/administration & dosage , Bleomycin/adverse effects , Chromosome Aberrations , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Cyclophosphamide/adverse effects , Disease Progression , Doxorubicin/administration & dosage , Doxorubicin/adverse effects , Doxorubicin/analogs & derivatives , Etoposide/administration & dosage , Etoposide/adverse effects , Fatal Outcome , HTLV-I Infections/complications , Human T-lymphotropic virus 1/isolation & purification , Humans , Japan , Leukemia, Myeloid/complications , Leukemia-Lymphoma, Adult T-Cell/complications , Lymphoma, T-Cell, Cutaneous/drug therapy , Lymphoma, T-Cell, Cutaneous/radiotherapy , Lymphoma, T-Cell, Cutaneous/virology , Male , Nitrosourea Compounds/administration & dosage , Nitrosourea Compounds/adverse effects , Prednisolone/administration & dosage , Prednisolone/adverse effects , Proviruses/isolation & purification , Remission Induction , Translocation, Genetic , Vincristine/administration & dosage , Vincristine/adverse effects
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