[Detection of the human papillomavirus in hyperplastic and cancerous prostatic tissue with PCR]. / Ricerca di papillomavirus umani nel tessuto prostatico iperplastico e canceroso mediante PCR.

Human papillomavirus (HPV) infections are frequently associated with benign, pre-malignant and malignant lesions of the female genital region and male anogenital tract. Recently several studies have been performed to evaluate the presence of HPV in the adenomatous and carcinomatous prostatic tissue for the epidemiological implications due to the sexual transmission, and for the possible etiologic role in the development of prostatic carcinoma, first cause of death from neoplasia in men over 60 years in the developed countries. The role of HPV is still controversial since some authors evidenced the virus in prostatic tissue others did not detect its presence. We investigate the presence of HPV in 60 prostatic benign hyperplasias and in 5 prostatic carcinomas in surgically resected prostates by PCR technique using consensus and type specific primers. The analyzed specimens were negative for HPV DNA, although appropriate amplimers were present for beta-globin and positive controls. We therefore conclude that HPV infections are not commonly found in the human prostate.

Paraffinoma of the penis: one-stage repair.

OBJECTIVE: We report a rare case of paraffinoma of penis. A one-stage surgical treatment achieved optimal aesthetic and functional results. METHODS: We evaluated a 32-year-old man who self injected paraffin into his penis to facilitate erection and increase potency. After two months of paraffin oil injection, sclerosis and retraction produced a deformity of the penis with erectile dysfunction. Complete removal of the compromised skin and subcutaneous tissue was performed and, simultaneously, a pedicled scrotal flap was accurately prepared, directly turned up and wrapped around the penile shaft with interrupted 3-0 silk sutures. The scrotal incision was then closed. RESULTS AND CONCLUSION: Treatment by excision of granulomatous tissue and plastic reconstruction in a one-stage procedure, as also reported in the literature, is the only treatment that is able to achieve an effective result, both cosmetically and functionally. Excellent aesthetic and functional results were found at 34-months follow-up.

Myelolipoma of the adrenal gland presenting with dyspepsia and epigastric pain.

Myelolipomas are rare benign neoplasms of the adrenal glands, characterized by the presence of adipose tissue and elements of bone marrow in various degrees of differentiation. Usually asymptomatic, they are discovered incidentally or at autopsy; sometimes larger masses may cause local symptoms. We report clinical, radiologic and therapeutic aspects of a large myelolipoma of the right adrenal gland, presenting with unusual epigastric symptoms.

[Simultaneous enucleo-resection of synchronous bilateral renal carcinoma, incidentally discovered during prostate disease screening]. / Enucleoresezione contemporanea di carcinoma renale bilaterale sincrono, scoperto incidentalmente nel corso di uno screening per le malattie della prostata.

Bilateral synchronous renal cell carcinoma is rare, incidental discovery is exceptional. We report a case of asymptomatic bilateral simultaneous renal tumor discovered during screening for prostatic disease. Two year previously the patient underwent sonography and IVP for right ureteral stone, spontaneously ejected, with no evidence of renal masses. Ultrasound, CT and selective digital angiography demonstrated two renal tumors < 3 cm in size. Bilateral simultaneous enucleoresection was the therapeutic choice, that we consider to be elective in such a case.

[Various echographic features in testicular torsion]. / I diversi aspetti ecografici nella torsione del testicolo.

The Authors discuss the informations that can be obtained from sonography in testicular torsion on the basis of 21 patients. The different sonographic features of the twisted testis, which are time-related, are reported and stressed. Ultrasonography is a very sensitive diagnostic tool and can be a useful complement of clinical examination.

[Rupture of the testicle: comparison of the echographic picture and operative findings]. / Fratture del testicolo: confronto fra quadri ecografici e reperti operatori.

9 patients suffering from testicular rupture, owing to blunt scrotal trauma, were examined with ultrasound and then underwent surgical exploration. Sonography correctly diagnosed testicular rupture in 8 patients, 1 false-negative occurred. Clinical examination often is difficult in evaluating testicular trauma, sonography provides a useful tool for improved diagnosis in testicular rupture.

Tissue distribution of drug-metabolizing enzymes in humans.

1. The activities of the ethoxycoumarin O-deethylase (ECOD), epoxide hydrolase (EH), UDP-glucuronyl transferase (GT), glutathione S-transferase (GST), acetyl transferase (AT) and sulphotransferase (ST) were measured in 6 liver, 8 lung, 8 kidney, 8 intestinal mucosa and 22 urinary bladder mucosa specimens from human subjects. EH and GT were studied with styrene oxide and 1-naphthol, respectively, as substrates, GST, AT and ST were studied with benzo(a)pyrene-4,5-oxide, p-aminobenzoic acid and 2-naphthol, respectively. 2. The enzyme activities were detectable at significant rates in liver, lungs, kidneys and gut. In urinary bladder, EH, GT, GST and ST only were detectable. The liver catalyzed the various reactions at higher rates than did other tissues. 3. Of the extrahepatic tissues, the intestinal mucosa contained the highest activities of AT (50% of liver) and ST (30% of liver), whereas kidneys contained the highest activity of GT (50% of liver) and GST (80% of liver). GST was the enzyme with the widest tissue distribution.

Blind-ending branch of bifid ureter: report of seven cases.

Seven cases of bifid ureter with a blind-ending branch are presented: diagnosis was primarily made by excretory urogram. In 1 case the diagnosis was confirmed by retrograde pyelogram. The pelvicalyceal system showed ureteroureteral reflux into the blind-ending branch on photofluoroscopy and cineroentgenography. One rare case of blind-ending branch originating in the upper third of the ureter are described. The clinical aspects, roentgenographic findings, and treatment of these findings are reviewed.

Prevention and management of urinary tract infections following endoscopic and urological surgery using one dose daily of tobramycin.

The therapeutic activity of a single dose of 150 mg of tobramycin, parenteral administration, was studied in the prophylaxis of urinary tract infection (UTI) postoperative or postendoscopic. This study incorporated 85 patients of both sexes ranging in age from 18-91 years; 20 had had previous UTI. Duration of therapy ranged from 5 to 15 days and was determined by clinical response; 70 of 85 patients clinically observed achieved excellent results, 10 good and 5 moderate. In 5 cases persistent asymptomatic bacteriuria recurred, indicating incomplete eradication of the microorganism. Results of data showed the clinical efficacy, safety and tolerance of tobramycin, in one dose only, in the prophylaxis of UTI posturological surgery, as well as its easy administration and limited cost.

Vascular impressions on the renal-collecting system: diuretic cine-roentgenographic and angiographic study of 50 cases.

The vascular impressions on the renal pelvis and caliceal system may assume an important role in the study of some patients with hematuria and renal pain of unclear origin. 50 patients presenting vascular impressions on the calices and renal pelvis have been studied. In 12 patients (24%) the impressions were bilateral and in 38 (76%) unilateral: in 35 patients (70%) the right kidney was involved. In each patient the morphological pyelocaliceal variations have been studied with cine-roentgen-dynamic investigations and in 30 angiography was also performed. Interesting results have been obtained with cine-roentgenographic investigations during forced diuresis allowing differentiation between intrinsic and extrinsic lesions of the renal collecting structures, without resorting to more complex investigations such as angiography.

Conservative surgery for renal cell carcinoma.

The authors present their clinical experience in conservative surgery for renal cell carcinoma, which was performed in two cases of simultaneous bilateral tumours, in a case of neoplasm in solitary kidney, in two cases of cancers with damaged contralateral kidney and in two cases of association between cyst and small tumour. All patients are alive and without evidence of residual or recurrent malignancy with a followup ranging between 6 months and 7 years. The pros and cons of the various surgical solutions are discussed.

[Radiological evolution of renal pelvis tumours (author's transl)]. / Quadri evolutivi delle neoplasie pielo-caliciali.

The tumours of renal pelvis show a polymorphic radiological pattern, often rather difficult to interpret, sometimes even not evident owing to the presence of some other pathology. The most characteristic cases, and to be considered specimen, found in researches executed at different times, are represented by carcinomas, among which the ones showing the most elevated histological malignancy present a more rapid and infiltrative growth, as testified by repeated radiological tests.