1.
Org Biomol Chem
; 16(39): 7120-7123, 2018 10 10.
Article
in English
| MEDLINE
| ID: mdl-30251722
ABSTRACT
Visible-light induced perfluoroalkylation of the α-position of aldehydes via enamines was developed. The reaction proceeds by electron donor-acceptor complexation of the enamine and perfluoroalkyl iodide without any additional redox catalyst. A variety of perfluoroalkyl groups are tolerated to give various quaternary α-perfluoroalkyl aldehydes. An example using proline-derived chiral amine gives high enantioselectivity.